aesculetindimethylether
6,7-dimethoxycoumarin
CAS: 120-08-1
Molecular Formula: C11H10O4
aesculetindimethylether - Names and Identifiers
| Name | 6,7-dimethoxycoumarin |
| Synonyms | scoparon Scoparone escoparone Scoparone 120-08-1 6,7-dimethylesculetin 6,7-dimethoxy-coumari 6,7-dimethoxycoumarin 6,7-Dimethoxycoumarine aesculetindimethylether 6,7-DIMETHOXY-CHROMEN-2-ONE 6,7-dimethoxy-2H-chromen-2-one 6,7-dihydroxy-3,4-dimethyl-1-benzopyran-2-one |
| CAS | 120-08-1 |
| EINECS | 204-369-0 |
| InChI | InChI=1/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3 |
aesculetindimethylether - Physico-chemical Properties
| Molecular Formula | C11H10O4 |
| Molar Mass | 206.19 |
| Density | 1.0858 (rough estimate) |
| Melting Point | 143-145 °C (lit.) |
| Boling Point | 265.04°C (rough estimate) |
| Flash Point | 166.8°C |
| Solubility | Soluble in ethanol, acetone, chloroform, insoluble in water, insoluble in petroleum ether. |
| Vapor Presure | 1.2E-05mmHg at 25°C |
| Appearance | White or yellow fluffy crystals |
| Merck | 13,8479 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4389 (estimate) |
| MDL | MFCD00006871 |
| Physical and Chemical Properties | White or yellowish white needle-like crystals. Melting point 144 °c. Soluble in chloroform, acetone, soluble in ethanol solution and sodium hydroxide solution, insoluble in petroleum ether and water. Odorless and bitter. |
| In vitro study | Scoparone (0-0.4 nM; 24-48 hours) produces the most inhibition on PSC proliferation at 0.4 nM. |
aesculetindimethylether - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S27/28 - S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | GN6550000 |
| HS Code | 29322090 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
aesculetindimethylether - Reference
| Reference Show more | 1. Qin Xiaohua and Lu Xiuyu. Study on Qualitative Quality Control Methods and Gallbladder Effects of Huashi Lidan Tablets [J]. Straits Pharmaceutical 2019 v.31;No.231(04):71-73. 2. Xu Jian, Lin Li, Wang Xiang. The role and mechanism of artemisia lactone in anti-atherosclerosis [J]. Modern Practical Medicine, 202,032 (001):25-28, feng 2. 3. Fang Yue, Huang Xuejuan, You Xinyi, et al. Determination of Plasma Protein Binding Rate of Wedelia Lactone Rats [J]. Pharmacy and Clinical Research, 2015(03):246-248. 4. He Wei, Cheng Huan, Tan Luochao. Anti-atherosclerosis effect and mechanism of Artemisolide [J]. China Coal Industry Medical Journal, 2020,23(06):561-567. 5. [IF = 4.411] Liang Yang et al."New Insights into the Antibacterial Activity of Hydroxycoumarins against Ralstonia solanacearum." Molecules. 2016 Apr;21(4):468 6. [IF = 2.408] Ying-Hui He et al."Antifungal Activity and Action Mechanism Study of Coumarins from Cnidium monnieri Fruit and Structurally Related Compounds." Chemistry & Biodiversity. 2021 Oct 27 |
aesculetindimethylether - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| biological activity | Scoparone (6, 7-dimethoxycumarin, Aesculetin dimethyl ether, 6, 7-Dimethylescuetin, Escoparone) is a natural organic compound extracted from the Chinese herbal medicine Artemisia sphaerocephala, which has anticoagulant, hypolipidemic, antioxidant and anti-inflammatory effects. |
| Animal Model: | Chronic Pancreatitis (CP) Rat Models |
| Dosage: | 30 mg/kg, 60 mg/kg |
| Administration: | Oral administration; 30 mg/kg, 60 mg/kg; 4 weeks |
| Result: | Protected against pancreatic damage |
| Use | Used as an intermediate in organic synthesis. This product is also a kind of medicine, has the effect of relieving asthma, expectorant and antitussive. MFCD00006871 |
| Production method | is obtained by reacting 6, 7-dihydroxycoumarin (C9H6O4,[305-01-1] with dimethyl sulfate. |
Last Update：2024-04-09 21:01:54
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Spot supply
Product Name: Scoparone Visit Supplier Webpage Request for quotationCAS: 120-08-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Scoparone Visit Supplier Webpage Request for quotationCAS: 120-08-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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