aescusan
Aescine
CAS: 6805-41-0
Molecular Formula: C55H86O24
aescusan - Names and Identifiers
aescusan - Physico-chemical Properties
| Molecular Formula | C55H86O24 |
| Molar Mass | 1131.26 |
| Density | 1.1200 (rough estimate) |
| Melting Point | 224.5°C |
| Boling Point | 764.81°C (rough estimate) |
| Flash Point | 311.8°C |
| Solubility | Soluble in methanol. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | white |
| Merck | 13,3730 |
| Storage Condition | 2-8℃ |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.6500 (estimate) |
| MDL | MFCD00076054 |
| In vitro study | Escin can effectively inhibit the proliferation of pancreatic cancer cells, but it has little effect on normal skeletal muscle cells. Escin enhances the proliferation-inhibiting and apoptosis-inducing effects of gemcitabine in BxPC-3 and PANC-1 cells. Escin also downregulates the activation of gemcitabine-induced NF-kB and its downstream gene products in pancreatic cancer cells. |
| In vivo study | Escin enhances the therapeutic effect of gemcitabine in nude mice bearing BxPC-3 xenografts. Ecin and gemcitabine have a significant synergistic effect on inhibiting the growth of pancreatic tumors, inhibiting proliferation and inducing apoptosis of tumor cells. Escin enhances the inhibitory effect of gemcitabine on NF-kB and NF-kB regulated gene products. |
aescusan - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R20/22 - Harmful by inhalation and if swallowed. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 2 |
| RTECS | KF6296000 |
aescusan - Reference
| Reference Show more | 1. Wang Mingmei, Wang Chenyang, Zhang Min, et al. Study on production of Escin by cell culture of Aesculus chinensis embryo [J]. Chinese herbal medicine 2017 040(007):1552-1557. 2. Wang Mingmei, Wang Chenyang, Zhang Min, et al. Callus culture and Escin content analysis of Aesculus chinensis embryo [J]. Journal of Biology, 2017, 34(004):53-57. 3. [IF = 4.36] Liudai Zhang et al."Amiliorative effects of escin on neuropathic pain induced by chronic constriction injury of sciatic nerve."J Ethnopharmacol. 2021 Mar;267:113503 4. [IF=1.959] Changjun Chen et al."Escin suppresses HMGB1‐induced overexpression of aquaporin‐1 and increased permeability in endothelial cells."Febs Open Bio. 2019 May;9(5):891-900 |
aescusan - Reference Information
| efficacy | The extracts from horse chestnut and horse chestnut, which promote the synthesis of pectin and repair damaged skin, can effectively moisturizing rich flavonoids, with natural strong anti-aging anti-wrinkle effect, can improve some eye skin blood circulation, and can also eliminate cellulite, dark circles and eye bags have some effect. |
| trait | brownish yellow to white crystalline powder; Slightly gas, bitter. |
| Use | Escin has the advantages of anti-tissue edema, reducing vascular permeability and preventing water accumulation in tissues, rapid elimination of the feeling of heaviness and pressure caused by local edema. It can be used to treat stomach cold pain, abdominal distention, Veratrum pain, malaria, dysentery. |
| biological activity | Escin (Aescin) is a mixture of saponins found in Aesculus chinensis Bunge, vascular protection. |
Last Update：2024-04-09 21:01:54
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Product Name: Horse chestnut extract Escin Visit Supplier Webpage Request for quotationCAS: 6805-41-0
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Spot supply
Product Name: Escin Visit Supplier Webpage Request for quotationCAS: 6805-41-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Escin Visit Supplier Webpage Request for quotationCAS: 6805-41-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Horse chestnut extract Escin Visit Supplier Webpage Request for quotationCAS: 6805-41-0
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402
WhatsApp: +86 18374838656
Linkedin: +86 18374838656
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