alpha-Methyltetrahydrofuran
2-Methyltetrahydrofuran
CAS: 96-47-9
Molecular Formula: C5H10O
alpha-Methyltetrahydrofuran - Names and Identifiers
| Name | 2-Methyltetrahydrofuran |
| Synonyms | 2-Methyltetrahydrofu 2-Methyltetrahydrofuran tetrahydro-2-methylfuran alpha-Methyltetrahydrofuran (2R)-2-methyltetrahydrofuran 2-Methyltetrahydrofuran,Tetrahydro-2-methylfuran, Tetrahydrosilvan 2-Methyltetrahydrofuran,For Grignard reaction,anhydrous, stabilized |
| CAS | 96-47-9 |
| EINECS | 202-507-4 |
| InChI | InChI=1/C5H10O/c1-5-3-2-4-6-5/h5H,2-4H2,1H3/t5-/m1/s1 |
alpha-Methyltetrahydrofuran - Physico-chemical Properties
| Molecular Formula | C5H10O |
| Molar Mass | 86.13 |
| Density | 0.86g/mLat 25°C(lit.) |
| Melting Point | -136 °C |
| Boling Point | 78-80°C(lit.) |
| Flash Point | 10.4°F |
| Water Solubility | 15 g/100 mL (25 C) |
| Solubility | 150g/l |
| Vapor Presure | 136 hPa (20 °C) |
| Appearance | Liquid |
| Color | Clear colorless |
| BRN | 102448 |
| Storage Condition | Store below +30°C. |
| Stability | Stable, but highly flammable. Incompatible with oxidizing agents, strong acids, strong bases. May form explosive peroxides in storage, so often supplied with an inhibitor added. |
| Explosive Limit | 1.2-5.7%(V) |
| Refractive Index | n20/D 1.406(lit.) |
| Physical and Chemical Properties | Character: colorless liquid. Has an ether-like odor. boiling point 80 ℃ freezing point -136 ℃ relative density 0.8552 refractive index 1.4025 flash point -11 ℃ solubility soluble in water, the solubility in water increases with decreasing temperature. Soluble in ethanol, ether, acetone, benzene and chloroform and other organic solvents. |
| Use | For pharmaceutical chloroquine phosphate intermediates |
alpha-Methyltetrahydrofuran - Risk and Safety
| Risk Codes | R11 - Highly Flammable R19 - May form explosive peroxides R36/37 - Irritating to eyes and respiratory system. R2017/11/19 - |
| Safety Description | S16 - Keep away from sources of ignition. S23 - Do not breathe vapour. S39 - Wear eye / face protection. S33 - Take precautionary measures against static discharges. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2536 3/PG 2 |
| WGK Germany | 2 |
| RTECS | LU2800000 |
| TSCA | Yes |
| HS Code | 29321900 |
| Hazard Class | 3 |
| Packing Group | II |
| Toxicity | LD50 orally in Rabbit: > 300 - 2000 mg/kg LD50 dermal Rat > 2000 mg/kg |
alpha-Methyltetrahydrofuran - Nature
Open Data Verified Data
colorless liquid. Has an ether-like odor. The relative density was 0.8552. The boiling point was 80 °c. Freezing point -136 °c. Refractive index 1.4025. Flash point -11 °c. Soluble in water, the solubility in water increases with decreasing temperature. Soluble in ethanol, ether, acetone, benzene and chloroform and other organic solvents.
Last Update：2024-01-02 23:10:35
alpha-Methyltetrahydrofuran - Preparation Method
Open Data Verified Data
2-methylfuran was hydrogenated at 150 ° C. With nickel catalysis to give a crude product. After dehydration and distillation, the finished product is obtained. In addition, in the production of acetyl n-Propyl alcohol can produce 2 methyl tetrahydrofuran.
Last Update：2022-01-01 10:56:53
alpha-Methyltetrahydrofuran - Use
Open Data Verified Data
This product is mainly used as a solvent for resin, natural rubber, ethyl cellulose and chloroacetic acid-vinyl acetate copolymer. It is used to extract aliphatic acids, which is better than the commonly used low boiling point solvent; it can also be used as an initiator for the polymerization of ethylene derivatives or butadiene, and 1, 3-pentadiene (an important raw material for synthetic rubber); It is also very important in the uranium smelting industry. In addition, it is also a raw material for the pharmaceutical industry, and can be used for the synthesis of the anti-hemorrhoidal drug, such as, for example, Bricanyl phosphate.
Last Update：2022-01-01 10:56:53
alpha-Methyltetrahydrofuran - Safety
Open Data Verified Data
- toxicity is similar to that of 2-methyl furan, see 2-methyl furan for details.
- packaged in iron drum. Store in a cool, ventilated, dry warehouse, no pyrotechnic. Handle with care, not inverted, avoid collision. The flammable and toxic substances shall be stored and transported according to the regulations. Iron drum packaging, net weight 170kg/barrel.
Last Update：2022-01-01 10:56:54
alpha-Methyltetrahydrofuran - Reference Information
| freezing point | -136 ℃ |
| Dielectric constant | 6.97 |
| LogP | 1.1 at 20℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | 2-methyltetrahydrofuran (hereinafter referred to as 2-me-thf) is an important bio-gasoline fuel, high-end environmentally friendly solvents and chemical intermediates. When used as a bio-gasoline fuel, it can be miscible with gasoline in any proportion and has excellent oxidation and vapor pressure properties. |
| Application | 2-methyltetrahydrofuran (hereinafter referred to as 2-MeTHF) is an important organic synthesis intermediate and solvent, it is a fine chemical material in the field of new materials and applications. In organic synthesis, it is mainly used in the synthesis of chloroquine phosphate, primaquine phosphate and thiamine. It is mainly used for organic synthesis of resin, natural rubber, ethyl cellulose and chloroacetic acid-vinyl acetate copolymer in solvent application. |
| purpose | mainly used for resin, rubber, solvent such as ethyl cellulose for pharmaceutical chloroquine phosphate intermediate mainly used as solvent for resin, natural rubber, ethyl cellulose and chloroacetic acid-vinyl acetate copolymer, in the pharmaceutical industry for the synthesis of anti-disease drugs such as primaquine phosphate. used as raw materials for the synthesis of drugs such as chloroquine phosphate and primaquine phosphate, and can also be used as solvent |
| production method | is obtained by catalytic hydrogenation of 2-methylfuran. When a palladium chloride catalyst is used for the catalytic hydrogenation reaction, the main product is acetyl propanol (see 00420), but 2-methyltetrahydrofuran, a by-product, can also be recovered. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | inhalation-rat 6000 PPM/ 4 H; Subcutaneous-rabbit LD50: 4500 mg/kg |
| stimulation data | eyes-rabbits 500 mg/24 h mild |
| flammability hazard characteristics | in case of open flame, high temperature, flammable oxidant; Combustion stimulus smoke |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
| autoignition temperature | 270°C |
Last Update：2024-04-09 20:44:15
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