amino-1,2,4-triazole

amino-1,2,4-triazole - Names and Identifiers

Name	Amitrole
Synonyms	amizol AMITROL AMIZOLE Amitrole AMITROLE AMIZOL(R) AMITROLE(R) aminotriazole AMINOTRIAZOLE Triazol-3-amine Sulfamidopyrine Amino-s-triazole Amino-1,2,4-triazole amino-1,2,4-triazole Melaminsulfone sodium 3-Amino-1,2,4-Triazole 1H-1,2,3-triazol-1-amine 1H-1,2,4-triazol-3-amine 3-Amino-1H-1,2,4-Triazole
CAS	61-82-5
EINECS	200-521-5
InChI	InChI=1/C2H4N4/c3-6-2-1-4-5-6/h1-2H,3H2

amino-1,2,4-triazole - Physico-chemical Properties

Molecular Formula	C2H4N4
Molar Mass	84.08
Density	1.138
Melting Point	150-153°C(lit.)
Boling Point	144.35°C (rough estimate)
Flash Point	101.9°C
Water Solubility	280 g/L (20 ºC)
Solubility	280g/l
Appearance	Powder or Flakes
Color	White to off-white or yellow
Exposure Limit	NIOSH REL: TWA 0.2 mg/m3; ACGIH TLV: TWA 0.2 mg/m3.
Merck	14,489
BRN	107687
pKa	11.14±0.20(Predicted)
PH	6.4-7.4 (100g/l, H2O, 20℃)
Storage Condition	Store below +30°C.
Stability	Stable. Incompatible with iron, copper, aluminium, acids, alkalies, strong oxidizing agents, acid chlorides, acid anhydrides. Forms chelates with some metals. Moisture sensitive.
Refractive Index	1.6260 (estimate)
Physical and Chemical Properties	White crystals or crystalline powders. Melting point 150-153 °c. Soluble in water, slightly soluble in methanol, ethanol, insoluble in ether, acetone.
Use	It is used as a herbicide and is particularly suitable for use as a cotton defoliant.

amino-1,2,4-triazole - Risk and Safety

Risk Codes	R48/22 - Harmful danger of serious damage to health by prolonged exposure if swallowed. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R63 - Possible risk of harm to the unborn child R40 - Limited evidence of a carcinogenic effect R61 - May cause harm to the unborn child
Safety Description	S13 - Keep away from food, drink and animal foodstuffs. S36/37 - Wear suitable protective clothing and gloves. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S53 - Avoid exposure - obtain special instructions before use.
UN IDs	UN 3077 9/PG 3
WGK Germany	2
RTECS	XZ3850000
TSCA	Yes
HS Code	29339990
Hazard Class	9
Packing Group	III
Toxicity	LD50 in mice, rats (g/kg): 14.7, 25.0 orally (Krller)

amino-1,2,4-triazole - Upstream Downstream Industry

Raw Materials

aminoguanidinium sulphate

amino-1,2,4-triazole - Nature

Open Data Verified Data

crystallization (water, ethanol or ethyl acetate),m.p.159 °c. LD50 (Rat oral) llOOmg/kg, animal experiments have carcinogenic and teratogenic effects.

Last Update：2024-01-02 23:10:35

amino-1,2,4-triazole - Preparation Method

Open Data Verified Data

there are aminoguanidine method, cyanamide hydrazine method.

prepared by reaction of aminoguanidine with formic acid.
The cyanamide-hydrazine method is obtained by reacting cyanamide, hydrazine hydrate and formic acid.

Last Update：2022-01-01 10:57:45

amino-1,2,4-triazole - Use

Open Data Verified Data

This product is used as a raw material for angina pectoris and coronary artery dilator zoxadiazine (Trapidil) in medicine. In terms of dyes used in the synthesis of basicyellow 25, basicred 22,Basic blue 93, etc.

Last Update：2022-01-01 10:57:44

amino-1,2,4-triazole - Reference Information

NIST chemical information	Information provided by: webbook.nist.gov (external link)
(IARC) carcinogen classification	3 (Vol. 79, Sup 7) 2001
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
Use	Used as a cationic dye intermediate, it can synthesize a variety of red dyes such as cationic red X-GRL; it is also a heterocyclic intermediate, which can be used in pharmaceuticals Can be used as a pharmaceutical intermediate. It is used in the synthesis of the drug zolazepine. used as herbicide, especially suitable for cotton defoliant.
Production method	It is obtained by cycliding hydrazine hydrate, cyanamide, and formic acid; or by the action of aminoguanide bicarbonate and formic acid, and then heating and cycliding; It can also be obtained by using guanidine nitrate as raw material, first reacting with acetic acid at a temperature of 5-15 ℃ for 8h, then reacting with oxalic acid, and finally refluxing for 5h.
category	pesticide
toxicity classification	poisoning
acute toxicity	oral-rat LD50: 1100 mg/kg; Oral-mouse LD50: 14700 mg/kg
flammability hazard characteristics	combustion produces toxic nitrogen oxide gas
storage and transportation characteristics	warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation
fire extinguishing agent	dry powder, foam, sand
occupational standard	TWA 0.2 mg/m3
spontaneous combustion temperature	>225°C
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-09 20:52:54

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amino-1,2,4-triazole

Raw Materials for amino-1,2,4-triazole

aminoguanidinium sulphate

amino-1,2,4-triazole

Amitrole

CAS: 61-82-5

Molecular Formula: C2H4N4

amino-1,2,4-triazole - Names and Identifiers

amino-1,2,4-triazole - Physico-chemical Properties

amino-1,2,4-triazole - Risk and Safety

amino-1,2,4-triazole - Upstream Downstream Industry

amino-1,2,4-triazole - Nature

Open Data Verified Data

amino-1,2,4-triazole - Preparation Method

Open Data Verified Data

amino-1,2,4-triazole - Use

Open Data Verified Data

amino-1,2,4-triazole - Reference Information

Supplier List

amino-1,2,4-triazole Request for Quotation

Amitrole

CAS: 61-82-5

Molecular Formula: C2H4N4

amino-1,2,4-triazole - Names and Identifiers

amino-1,2,4-triazole - Physico-chemical Properties

amino-1,2,4-triazole - Risk and Safety

amino-1,2,4-triazole - Upstream Downstream Industry

amino-1,2,4-triazole - Nature

Open Data Verified Data

amino-1,2,4-triazole - Preparation Method

Open Data Verified Data

amino-1,2,4-triazole - Use

Open Data Verified Data

amino-1,2,4-triazole - Reference Information

Supplier List

amino-1,2,4-triazole