arginyl-glycyl-aspartyl-serine
Arg-Gly-Asp-Ser
CAS: 91037-65-9
Molecular Formula: C15H27N7O8
arginyl-glycyl-aspartyl-serine - Names and Identifiers
arginyl-glycyl-aspartyl-serine - Physico-chemical Properties
| Molecular Formula | C15H27N7O8 |
| Molar Mass | 433.42 |
| Density | 1.65±0.1 g/cm3(Predicted) |
| Melting Point | 183-187℃ |
| Water Solubility | Soluble in water at 1mg/ml |
| Appearance | White to off-white powder |
| pKa | 2.84±0.10(Predicted) |
| Storage Condition | -20°C |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00076452 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | The Arg-Gly-Asp-Ser-modified surface causes up-regulation of αvβ3integrin. Attachment to the Arg-Gly-Asp-Ser-treated membrane completely abolishes apoptosis induced by staurosporine, the Ca 2+ ·Pi ion pair, and sodium nitroprusside. Arg-Gly-Asp-Ser-dependent resistance to apoptosis is eliminated, when the activity of the phosphatidylinositol 3-kinase pathway is inhibited. Arg-Gly-Asp-Ser interacts with survivin, as well as with procaspase-3, -8 and -9. Arg-Gly-Asp-Ser-peptide binding to survivin is found to be specific, at high affinity (K d 27.5 μM) and locates at the survivin C-terminus. Arg-Gly-Asp-Ser-survivin interaction appears to play a key role, since Arg-Gly-Asp-Ser lost its anti-mitogenic effect in survivin-deprived cells with a specific siRNA. |
| In vivo study | Arg-Gly-Asp-Ser (2.5 or 5 mg/kg, 1 h before LPS) significantly inhibits LPS-induced MMP-9 activity in BAL fluid 4 h post-LPS. Arg-Gly-Asp-Ser (1, 2.5 or 5 mg/kg, i.p.) administers 1 h before LPS inhibited LPS-induced increases in TNF-α and MIP-2 levels in BAL fluid at 4 h post-LPS. Arg-Gly-Asp-Ser peptide significantly reduces tumor necrosis factor (TNF)-α and macrophage inflammatory protein (MIP)-2 production, and decreases myeloperoxidase (MPO) and NF-κB activity. |
arginyl-glycyl-aspartyl-serine - Risk and Safety
| WGK Germany | 3 |
arginyl-glycyl-aspartyl-serine - Introduction
A tetrapeptide that supports fibroblast attachment and inhibits fibronectin binding.
Last Update：2022-10-16 17:41:51
arginyl-glycyl-aspartyl-serine - Reference Information
| biological activity | Arg-Gly-Asp-Ser are integrin binding sequences, inhibit integrin receptor function, reduce systemic inflammation by inhibiting leukocyte activation initiated by collagen, and weaken the expression of inflammatory cytokines, iNOS and MMP-9. |
Last Update：2024-04-09 21:48:26
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Product Name: Arg-Gly-Asp-Ser Visit Supplier Webpage Request for quotationCAS: 91037-65-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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