aspirinacetaminophenester
benorilate
CAS: 5003-48-5
Molecular Formula: C17H15NO5
aspirinacetaminophenester - Names and Identifiers
| Name | benorilate |
| Synonyms | benoral benortan benorilate Benorylate benorilato fenasparate aspirinacetaminophenester p-acetamidophenylacetylsalicylate 4-acetamidophenyl O-acetylsalicylate 4'-(acetamido)phenyl-2-acetoxybenzoate 2-acetoxy-4'-(acetamino)phenylbenzoate 4-(acetylamino)phenyl 2-(acetyloxy)benzoate |
| CAS | 5003-48-5 |
| EINECS | 225-674-5 |
| InChI | InChI=1/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H,1-2H3,(H,18,19) |
aspirinacetaminophenester - Physico-chemical Properties
| Molecular Formula | C17H15NO5 |
| Molar Mass | 313.3 |
| Density | 1.2016 (rough estimate) |
| Melting Point | 177-181℃ |
| Boling Point | 453.11°C (rough estimate) |
| Flash Point | 279°C |
| Water Solubility | 20mg/L(21 ºC) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.23E-11mmHg at 25°C |
| Appearance | Solid |
| Color | White |
| Merck | 14,1045 |
| pKa | 14.17±0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4500 (estimate) |
| Physical and Chemical Properties | White crystalline powder. Melting Point 175-176 °c. Soluble in hot alcohol, insoluble in water. |
| Use | Esterification of acetaminophen and aspirin, suitable for rheumatoid arthritis, rheumatoid arthritis, Head Pain, neuralgia, fever, etc |
aspirinacetaminophenester - Risk and Safety
| RTECS | VO0720000 |
| Toxicity | LD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson) |
aspirinacetaminophenester - Upstream Downstream Industry
| Raw Materials | Thionyl chloride |
aspirinacetaminophenester - Standard
Authoritative Data Verified Data
This product is 4-acetylaminophenyl acetylsalicylate. The content of C17H15N05 shall be between 99.0% and 102.0% based on the dry product.
Last Update：2024-01-02 23:10:35
aspirinacetaminophenester - Trait
Authoritative Data Verified Data
- This product is white crystal or crystalline powder; Odorless.
- This product is soluble in boiling ethanol, soluble in boiling methanol, slightly soluble in methanol or ethanol, insoluble in water.
melting point
The melting point of this product (General 0612) is 177~181°C.
absorption coefficient
take this product, precision weighing, plus absolute ethanol dissolution and quantitative dilution to make a solution containing about 7.5ug per lml, according to UV-visible spectrophotometry (General 0401) determination, the absorbance was measured at a wavelength of 240nm, and the absorption coefficient was 730 to 760.
Last Update：2022-01-01 11:32:19
aspirinacetaminophenester - Differential diagnosis
Authoritative Data Verified Data
- take about 0.2g of this product, add 5ml of sodium hydroxide test solution, boil, cool, filter, add appropriate amount of hydrochloric acid to the filtrate, and add 2 drops of ferric chloride test solution to show Pansy color.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 42).
- take about 0.lg of this product, add 5ml of dilute hydrochloric acid, boil, cool, filter, the filtrate shows the identification reaction of aromatic first amine (General rule 0301).
Last Update：2022-01-01 11:32:20
aspirinacetaminophenester - Exam
Authoritative Data Verified Data
chloride
take 2.0g of this product, add 100ml of water, heat and boil, cool, add water to 100ml, shake, filter, take 25ml filtrate, check according to law (General rule 0801), not more concentrated (0.01%) than the control solution made of 5ml of standard sodium chloride solution.
sulfate
take 25ml of the filtrate remaining under the chloride item and check it according to law (General 0802). Compared with the control solution made of 1 ml of standard potassium sulfate solution, it should not be more concentrated (0.02%).
p-amino group
take 1.0g of this product, add 20ml of methanol solution (1-2), stir well, add 1ml of basic sodium nitrosoferricyanide solution, shake well, place for 30 minutes, and do not show blue-green.
free salicylic acid
take 0.lg of this product, add 5ml ethanol, heat and dissolve, add an appropriate amount of water, shake, filter a 50ml Cuvette, add water to make 50ml, immediately add a new dilute ammonium ferric sulfate solution (take 1ml of lmol/L hydrochloric acid solution, add 2ml of ammonium ferric sulfate indicator solution, then add an appropriate amount of water to make 100ml), shake, within 30 seconds such as color, add 0.lg of salicylic acid into 1000ml measuring flask, add 1ml of glacial acetic acid, shake well, add appropriate amount of water to the scale, shake well, take 1ml, add 5ml of ethanol and 44ml of water, then add 1ml of the newly prepared dilute ammonium ferric sulfate solution, shake well), and no deeper (0.1%).
Related substances
new system for clinical use. Take this product, add methanol to dissolve and dilute to make a solution containing 0.4mg per lml, shake well, as a test solution; Take lml accurately and put it in a 100ml measuring flask, dilute to the scale with methanol, shake, as a control solution; Another appropriate amount of acetaminophen control was taken, dissolved in methanol and diluted to prepare a solution containing about 10ug per 1 ml as a control solution. According to the chromatographic condition test under the content determination item, the sample solution, the reference solution and the control solution are respectively l0ul, and the human liquid chromatograph is injected respectively, record the chromatogram to 2.5 times of the retention time of the main component peak. If there are chromatographic peaks in the chromatogram of the test solution that are consistent with the retention time of the main component peak of the reference solution, the peak area shall not be greater than 0.1 times (0.1%) of the main peak area of the control solution, and the peak area of other individual impurities shall not be greater than 0.5 times (0.5%) of the main peak area of the control solution, the sum of each impurity peak area shall not be greater than the main peak area of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 11:32:21
aspirinacetaminophenester - Content determination
Authoritative Data Verified Data
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Water (with phosphoric acid to adjust the pH value to 3.5 )-methanol (44:56) as mobile phase; the detection wavelength was 240nm. The number of theoretical plates shall not be less than 3000 calculated by Benorilate peak, and the separation degree between Benorilate peak and adjacent impurity peak shall meet the requirements.
- determination of this product, precision weighing, and methanol dissolution and quantitative dilution of about 0.4mg per lml of solution, shake, precision amount of 10u1 injection of human liquid chromatography, the chromatogram was recorded; The reference substance of Benorilate was taken and determined by the same method. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:32:21
aspirinacetaminophenester - Category
Authoritative Data Verified Data
antipyretic analgesic, non-steroidal anti-inflammatory drugs.
Last Update：2022-01-01 11:32:21
aspirinacetaminophenester - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:32:22
aspirinacetaminophenester - Benorilate Tablets
Authoritative Data Verified Data
This product contains Benorilate (C17H15N05) should be 95.0% to 105.0% of the label.
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product, according to the identification (1), (3) under the item of Benorilate, the test should show the same reaction.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- Related substances take this product, add methanol to dissolve and make a solution containing about 0.4mg of Benorilate per 1 ml, filter, and take the continued filtrate as the test solution (ready for new preparation). If there are chromatographic peaks with the same retention time as the main component peak of the reference solution in the chromatogram of the test solution determined according to the method for the related substances of Benorilate, the peak area shall not be greater than 0.2 times (0.2%) of the main peak area of the control solution, and the peak area of other individual impurities shall not be greater than the main peak area of the control solution (1.0% ), the sum of each impurity peak area shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution.
- the dissolution of this product, according to the dissolution and release determination method (General 0931 second method), with 1% sodium dodecyl sulfate solution 1000ml as the dissolution medium, the speed is 100 rpm, operate in accordance with the law, after 45 minutes, take the appropriate amount of solution, filter, take the filtrate lm (0.2g 2mD, put it in 50ml measuring flask, dilute it to the scale with water, shake it, as a test solution; Another reference product of Benorilate (about 20mg) was added into a 50ml measuring flask, dissolved with anhydrous ethanol and diluted to the scale. Then, the solution was shaken, and 2ml was accurately measured, in a 0.02% measuring flask, dilute to the mark with 0.04% sodium dodecyl sulfate solution (g of sodium dodecyl sulfate solution in a specification), and shake to obtain a reference solution. The absorbance of each of the above two Solutions was measured at a wavelength of 0401 Mn by ultraviolet-visible spectrophotometry (general), and the elution amount of each tablet was calculated. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 10 tablets of this product, precision weighing, fine grinding, precision weighing fine powder (about 20mg equivalent to Benorilate), methanol was added to dissolve and diluted to prepare a solution containing about 0.4mg of Benorilate per 1 ml, filtered, and the filtrate was taken as a test solution. According to the method under the content determination of Benorilate, it is obtained.
category
with Benorilate.
specification
(1)0.2g (2)0.4g (3)0.5g
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:32:22
aspirinacetaminophenester - Reference Information
| Pharmacological action and mechanism of action | Benorilate is a neutral compound that binds aspirin and acetaminophen with ester bonds. It has antipyretic and analgesic effects, and has less adverse reactions than aspirin. Patients are easy to tolerate. After oral administration, it is not hydrolyzed in the gastrointestinal tract, absorbed in the intestine and quickly reaches an effective concentration in the blood. The characteristic is that it rarely causes gastrointestinal bleeding. |
| adverse reactions | 1. mild gastrointestinal reactions such as vomiting, constipation, heartburn, etc. have also been reported to cause diarrhea. 2. It can cause rash. 3. still visible drowsiness, dizziness, disorientation and other neurological and mental symptoms. |
| use | this product is the esterification product of aspirin and paracetamol, and is a new anti-inflammatory, antipyretic, analgesic and rheumatic drug. Adverse reactions are smaller than aspirin, and patients are easy to tolerate. After oral administration, it is not hydrolyzed in the gastrointestinal tract, is easily absorbed and quickly reaches an effective concentration in the blood. Mainly used for rheumatoid arthritis, acute and chronic rheumatoid arthritis, rheumatic pain, cold and fever, headache, postoperative pain, neuralgia, etc. Adverse reactions include vomiting, dyspepsia and constipation. Sleepiness, dizziness and disorientation can still be seen. When the dosage is too large, most people may have tinnitus and deafness. Use with caution in patients with liver and kidney function impairment. Aspirin allergy is contraindicated. The oral LD50 was 2000mg/kg for mice and -10000mg/kg for rats. The LD50 was 1255mg/kg for mice and 1830mg/kg for rats. The esterification of acetaminophen and aspirin, suitable for rheumatoid arthritis, rheumatoid arthritis, headache, neuralgia, fever, etc. |
| Production method | Acetylsalicylic acid is acyl chlorinated to generate acetylsalicylchloride, which is then condensed with p-acetamido phenol to obtain benorilate. |
Last Update：2024-04-09 18:58:34
Supplier List
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Product Name: Benorilate Visit Supplier Webpage Request for quotationCAS: 5003-48-5
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Multiple SpecificationsSpot supply
Product Name: Benorilate Visit Supplier Webpage Request for quotationCAS: 5003-48-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for aspirinacetaminophenester