basedol
2-Aminothiazole
CAS: 96-50-4
Molecular Formula: C3H4N2S
basedol - Names and Identifiers
| Name | 2-Aminothiazole |
| Synonyms | abadole basedol BASEDOL aminothiazole 2-Thiazolamine 2-thiazylamine 2-Aminothiazole 2-thiazole amine 2-thiazolylamine 2-Aminothiazole sky 1,3-Thiazol-2-amine 2-Aminothiazole 2921 2-Amino-1,3-thiazole 2-AMINO THIOZOLE (96-50-4) |
| CAS | 96-50-4 |
| EINECS | 202-511-6 |
| InChI | InChI=1/C3H4N2S/c4-3-5-1-2-6-3/h1-2H,(H2,4,5) |
| InChIKey | RAIPHJJURHTUIC-UHFFFAOYSA-N |
basedol - Physico-chemical Properties
| Molecular Formula | C3H4N2S | ||||||||||||||
| Molar Mass | 100.14 | ||||||||||||||
| Density | 1.241 (estimate) | ||||||||||||||
| Melting Point | 91-93 °C (lit.) | ||||||||||||||
| Boling Point | 117 °C (15.002 mmHg) | ||||||||||||||
| Flash Point | 117°C/15mm | ||||||||||||||
| Water Solubility | 100 g/L (20 ºC) | ||||||||||||||
| Solubility | 1 M HCl: soluble50mg/mL, clear (dark yellow-brown) | ||||||||||||||
| Vapor Presure | <1 hPa (20 °C) | ||||||||||||||
| Appearance | Crystalline Powder, Grains, Lumps or Flakes | ||||||||||||||
| Color | Brown | ||||||||||||||
| Merck | 14,479 | ||||||||||||||
| BRN | 105738 | ||||||||||||||
| pKa | 5.36(at 20℃) | ||||||||||||||
| PH | 9.6 (100g/l, H2O, 20℃) | ||||||||||||||
| Storage Condition | Store below +30°C. | ||||||||||||||
| Refractive Index | 1.5300 (estimate) | ||||||||||||||
| Physical and Chemical Properties |
| ||||||||||||||
| Use | Used as pharmaceutical and dye intermediates |
basedol - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R36/37 - Irritating to eyes and respiratory system. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S39 - Wear eye / face protection. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | XJ2100000 |
| FLUKA BRAND F CODES | 8-9 |
| TSCA | Yes |
| HS Code | 29341000 |
| Hazard Note | Irritant |
| Toxicity | LD50 orally in Rabbit: 480 mg/kg |
basedol - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | for pharmaceutical intermediates. For organic synthesis. 2-aminothiazole is mainly used for the synthesis of Nitrosulfathiazole, Sulfathiazole, Sulfasuxidinum, maleamidothiazole, phthalyl sulfathiazole, creatole, Salazosulfathiazole for use in ultrasound-mediated mild Ulmann coupling reaction with 2-chlorobenzoic acid , dye intermediate |
| production method | by thiourea with chloroacetaldehyde (or ethanol and chlorine, or alpha, beta dichloroethyl ether) obtained by cyclization. The reactor was charged with hot water, thiourea and α,β-dichloroethyl ether. Reflux for 2H with stirring. After cooling, sodium hydroxide solution was added through a dropping funnel to make the solution alkaline, and 2-aminothiazole crystals were precipitated. Ether was then added to dissolve it. The ether layer was separated, washed with water, dried over anhydrous sodium sulfate, and ether was distilled off to give a crude product. Recrystallization from ethanol yielded yellow crystals. The yield was 80%, melting point 90 °c. |
| category | explosive articles |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LD50: 480 mg/kg; Intraperitoneal-mouse LD50: 200 mg/kg |
| explosive hazard characteristics | its nitric acid mixture; Or its nitric acid-sulfuric acid mixture heat explosion |
| flammability hazard characteristics | flammable; Toxic nitrogen oxides and sulfur oxides smoke generated at high temperature |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from nitric acid and sulfuric acid |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
| autoignition temperature | 600°C |
Last Update：2024-04-09 20:52:54
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