Name | 2H-1,3-benzoxazine-2,4(3H)-dione |
Synonyms | ruhmal carsalam beaprine oxophenhydroxazine TIMTEC-BB SBB003929 1,3-BENZOXAZINE-2,4-DIONE 1,3-Benzoxazine-2,4-(3H)-dione 2H-1,3-benzoxazine-2,4(3H)-dione |
CAS | 2037-95-8 |
InChI | InChI=1/C8H5NO3/c10-7-5-3-1-2-4-6(5)12-8(11)9-7/h1-4H,(H,9,10,11) |
Molecular Formula | C8H5NO3 |
Molar Mass | 163.13 |
Density | 1.402±0.06 g/cm3(Predicted) |
Melting Point | 228-232°C(lit.) |
Vapor Presure | 0.73-1.27Pa at 89.94-107.94℃ |
Appearance | Solid |
Merck | 13,1879 |
pKa | 9.16±0.20(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.585 |
MDL | MFCD00600566 |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
Safety Description | 36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | DM3110000 |
LogP | 0.78-0.88 at 20℃ |
application | 1,3-benzoxazine -2,4(3H)-dione can be used as an intermediate in pharmaceutical and chemical synthesis and plays an important role. Such as preparing 8-(2-hydroxybenzamido) sodium caprylate. 8-(2-hydroxybenzamido) sodium octoate, referred to as SNAC, is a two-carbon phosphate compound absorption promoter, used to treat gastrointestinal diseases, especially suitable for two-carbon phosphate compound malabsorption caused by gastrointestinal diseases. |
preparation | 1,3-benzoxazine -2,4(3H)-dione preparation is as follows: in a 250mL three-mouth flask, 7g(0.051mol) of salicylamide, 16mL of acetonitrile and 19mL of pyridine are added. Stirring dropwise 5.32mL ethyl chloroformate (0.056mol) dissolved in 10mL acetonitrile solution at 0-5 ℃. Slowly raise the temperature to 10 ℃ and stir for 30min, then raise the temperature to reflux to continue stirring reaction, TLC tracking to the end point. After a little cooling, pour the reaction solution into cold water to precipitate white solids. The filter cake was recrystallized with ethanol to obtain 6.95g of white flake crystal 1,3-benzoxazine -2,4(3H)-diketone with melting point of 223-224 ℃ and yield of 83%. |
biological activity | Carsalam (Carbonylsalicylamide) is a non-steroidal anti-inflammatory drug. |