benidipine
Benidipine
CAS: 105979-17-7
Molecular Formula: C28H31N3O6
benidipine - Names and Identifiers
benidipine - Physico-chemical Properties
| Molecular Formula | C28H31N3O6 |
| Molar Mass | 505.56 |
| Density | 1.29±0.1 g/cm3(Predicted) |
| Boling Point | 625.2±55.0 °C(Predicted) |
| Flash Point | 331.9°C |
| Water Solubility | 316μg/L at 25℃ |
| Vapor Presure | 1.5E-15mmHg at 25°C |
| pKa | pKa 7.34(H2O(long extrapolation)) (Uncertain) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.621 |
| Physical and Chemical Properties | Α-configuration hydrochloride: C28H3l N3O6? HCl. [91599-74-5]. Yellow crystalline powder, melting point 199.4~200.4 °c. UV maximum absorption (ethanol):238,359nm (λ28000, 6680). Solubility (%) at 25 °c: methanol 6.9, ethanol 2.2, water 0.19, chloroform 0.16, acetone 0.13, ethyl acetate 0.0056, toluene 0.0019,n-pentane 0.00009. pKa 7.34. Partition coefficient (N-octanol/water):1.23 x 103(pH = 6.4,22 °c). Acute toxicity LD50 mice (mg/kg):218 oral. |
| Use | Dihydropyridine calcium antagonists for hypertension and angina pectoris. Method 1: acid chloride method. 2.5g(-)-2, 6-dimethyl-4-(3-nitrophenyl)-l, 4-dihydropyridine-3, 5-dicarboxylic acid monomethyl ester (Ⅰ) and 0.57ml of thionyl chloride, reaction in dichloromethane-dimethylformamide, acid chloride (II). (II) and 1.51g of ()-1-benzyl-3-hydroxypiperidine were reacted for 2H to give 2.72g of ()-α-benidipine hydrochloride after acidification. (-)-benidipine hydrochloride is also available. Method 2: routine cyclization. The side chains were prepared as the corresponding acetoacetate (III). Then (III) and 3-nitrobenzaldehyde and methyl 3-aminobutenate were heated in isopropanol to form benidipine. |
benidipine - Use
Open Data Verified Data
developed by Nippon Concorde fermentation Co., Ltd., launched in October 1991. It is a dihydropyridine calcium antagonist. For hypertension and angina. It can relax blood vessels, reduce blood pressure and increase coronary flow. It is stronger than nifedipine, but its bioavailability is lower.
Last Update：2024-01-02 23:10:35
benidipine - Safety
Open Data Verified Data
benidipine hydrochloride male mice oral LD50 (mg/kg):218.
Last Update：2022-01-01 09:10:24
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