benzene,1-bromo-4-methyl-
4-Bromotoluene
CAS: 106-38-7
Molecular Formula: C7H7Br
benzene,1-bromo-4-methyl- - Names and Identifiers
| Name | 4-Bromotoluene |
| Synonyms | ai328596 p-Tolybromide 4-Bromotoluene p-bromotoluene p-bromo-toluen Toluene, p-bromo- 1-Brom-4-methylbenzol 1-Bromo-4-methylbenzene 1-bromo-4-methyl-benzen 1-Methyl-4-bromobenzene benzene,1-bromo-4-methyl- |
| CAS | 106-38-7 |
| EINECS | 203-391-8 |
| InChI | InChI:1S/C7H7Br/c1-6-2-4-7(8)5-3-6/h2-5H,1H3 |
benzene,1-bromo-4-methyl- - Physico-chemical Properties
| Molecular Formula | C7H7Br |
| Molar Mass | 171.03 |
| Density | 1.39g/mLat 25°C(lit.) |
| Melting Point | 26-29°C(lit.) |
| Boling Point | 184°C(lit.) |
| Flash Point | 185°F |
| Solubility | 0.11g/l insoluble |
| Vapor Presure | 1.04mmHg at 25°C |
| Appearance | Crystalline Low Melting Mass |
| Specific Gravity | 1.390 |
| Color | White |
| Merck | 14,1439 |
| BRN | 1903636 |
| Storage Condition | Store below +30°C. |
| Refractive Index | 1.549 |
| Physical and Chemical Properties | Character: colorless liquid. melting point 28.5 ℃ boiling point 184.35 ℃ relative density 1.3995 refractive index 1.5477 solubility insoluble in water, soluble in ethanol, ether. |
| Use | Used as raw materials and intermediates in organic synthesis, used in pharmaceutical industry |
benzene,1-bromo-4-methyl- - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R38 - Irritating to the skin R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | XS7965600 |
| TSCA | Yes |
| HS Code | 29036990 |
| Hazard Class | 9 |
| Packing Group | III |
benzene,1-bromo-4-methyl- - Upstream Downstream Industry
| Raw Materials | p-Toluidine Sodium bromide Sodium bromide |
| Downstream Products | 4-Bromobenzoic acid |
benzene,1-bromo-4-methyl- - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| properties | p-bromotoluene is a white crystal, soluble in ethanol, ether and benzene, insoluble in water. |
| Introduction | p-bromotoluene, also known as 4-bromotoluene, 1-bromo-4-methylbenzene. Colorless liquid at room temperature, insoluble in water, soluble in ethanol, ether. P-bromotoluene is a toxic chemical, harmful to swallow, the eyes, respiratory system and skin irritation. Flammable. P-bromotoluene is a raw material for organic synthesis, which is widely used in fuel and pharmaceutical industry. It is an intermediate for the manufacture of p-bromobenzyl, P-bromodibenzyl and p-bromobenzaldehyde. High purity of p-bromotoluene is an intermediate of the important best-selling drug-the antihypertensive drug Losantan. |
| Application | p-bromotoluene is mainly used for the synthesis of p-bromobenzyl, P-bromophenylacetonitrile, P-bromotrifluorotoluene, P-bromocinnamic acid, P-bromobenzaldehyde, P-bromobenzoic acid and other important raw materials of pharmaceutical intermediates, many domestic organic synthesis has been widely used. used in organic synthesis used as raw materials and intermediates in organic synthesis, used in pharmaceutical industry |
| production method | is obtained by diazotization and substitution of p-toluidine. First, the sulfuric acid aqueous solution was added to the pulverized p-toluidine while hot, cooled to 5 ° C., and the sodium nitrite aqueous solution was slowly added until the starch potassium iodide test paper turned blue. A small amount of urea is then added to destroy the excess sodium nitrite. The synthesized cuprous bromide was then added to hydrobromic acid, heated to boiling, and then the above diazonium salt was slowly added and distilled until an oily substance did not appear. Washing, drying, filtration, atmospheric pressure distillation, collected 183-185 °c fraction to obtain the finished product. The cuprous bromide-hydrobromic acid solution can be prepared as follows: the mixture of copper sulfate, copper shavings, sodium bromide dihydrate, concentrated sulfuric acid and water is heated and refluxed for 3-4H, until the solution becomes pale yellow, that is, cuprous bromide-hydrobromic acid solution. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | intraperitoneal-mouse LD50: 1741 mg/kg |
| flammability hazard characteristics | open flame flammable; Thermal decomposition of toxic bromide gas |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Storage and transportation are separated from oxidant and food raw materials |
| extinguishing agent | carbon dioxide, sand, foam, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:04
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Raw Materials for benzene,1-bromo-4-methyl-
Downstream Products for benzene,1-bromo-4-methyl-