beta,
xanthophyll from alfalfa
CAS: 127-40-2
Molecular Formula: C40H56O2
beta, - Names and Identifiers
| Name | xanthophyll from alfalfa |
| Synonyms | beta, Lutein E 161b SAG-1000 Xanthophyll Gamma-Lutein beta,e-carotene-3, XANTHOPHYLL FROM CORN xanthophyllfromalfalfa xanthophyll from alfalfa beta,e-carotene-3,3'-diol 3,3-Dihydroxy-alpha-carotene Xanthophyll, In Corn Oil Base beta,epsilon-carotene-3,3-diol beta,epsilon-carotene-3,3'-diol 4,5-didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol epsilon-carotene-3,3'-diol,(3theta,3'theta,6'theta)-bet (3R,3'S,6R)-4,5-didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol (3R,3'R,6R)-4,5-didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol (3R,6'R)-4',5'-didehydro-5',6'-dihydro-beta,beta-carotene-3,3'-diol Calendula Infused Oil |
| CAS | 127-40-2 |
| EINECS | 204-840-0 |
| InChI | InChI=1/C40H56O2/c1-29(17-13-19-31(3)21-23-37-33(5)25-35(41)27-39(37,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-38-34(6)26-36(42)28-40(38,9)10/h11-25,35-37,41-42H,26-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t35?,36-,37+/m1/s1 |
| InChIKey | KBPHJBAIARWVSC-RGZFRNHPSA-N |
beta, - Physico-chemical Properties
| Molecular Formula | C40H56O2 |
| Molar Mass | 568.87 |
| Density | 0.9944 (rough estimate) |
| Melting Point | 195 °C |
| Boling Point | 572.66°C (rough estimate) |
| Specific Rotation(α) | 18Cd +165° (c = 0.7 in benzene) |
| Flash Point | 269.1±27.5 °C |
| Solubility | Insoluble in water. Soluble in an oily solvent. |
| Vapor Presure | 8.45E-23mmHg at 25°C |
| Appearance | Crystalline Coppery powder with metallic luster |
| Color | Red to Very Dark Red |
| Maximum wavelength(λmax) | ['λ: 441-451 nm Amax'] |
| Merck | 13,10120 |
| BRN | 2068547 |
| pKa | 14.61±0.70(Predicted) |
| Storage Condition | -20°C |
| Stability | Light Sensitive, Temperature Sensitive |
| Sensitive | Sensitive to air |
| Refractive Index | n20/D1.361-1.363 |
| MDL | MFCD00017353 |
| Physical and Chemical Properties | Crystalline with metallic luster. melting point 183 °c solubility insoluble in water. Soluble in oily solvent. |
| Use | Can be used for food coloring, can also be added to the poultry feed, the egg yolk to enhance the yellow |
beta, - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 1-8-10-16 |
| HS Code | 29061990 |
beta, - Efficacy and role
Open Data Unverified Data
1. Antibacterial and anti-inflammatory : The antibacterial ingredients in calendula extract have better effect in alkaline environment.
2. lowering blood lipid : The saponins in calendula can reduce serum cholesterol, free fatty acids, phospholipids, β-lipoproteins, total lipids and triglyceride in patients with hyperlipidemia, cholesterol and triglycerides also have a lowering effect.
Last Update：2024-04-09 19:43:38
beta, - Reference Information
| Plant source: | Marigold |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | lutein, a star of hope in the field of botany substances, is now being favored by people. Lutein is not only an antioxidant that inhibits the risk of cancer and heart disease, but also plays an important role in protecting the eyes. Lutein is an important carotenoid in the eye. According to a recent report in Ophthalmology, lutein-containing foods can prevent cataracts and protect the eyes with spot lesions caused by age. |
| preparation | weigh 600g of lutein extract and 10g of 6% vitamin c aqueous solution, add into a 5000ml round-bottom flask, dissolve 138g of analytical grade KOH in 600g of 95% alcohol, then add KOH ethanol solution into the round-bottom flask under stirring, and saponification reaction at 60 ℃ for 3h, 600g of distilled water at 60 ℃ is added for dilution, then alcohol is recovered in a vacuum environment with a pressure of -0.08Mpa and a temperature of 60 ℃ to obtain 389g of 91% (volume ratio) alcohol. Finally, 3000ml of 0.2mol/l hydrochloric acid aqueous solution at 60 ℃ is added, stirred for 60min, kept warm and stood for 2h, lutein crystals are centrifuged, and the crystals are washed with distilled water, under the conditions of-0.095Mpa and drying temperature of 30 ℃, the crystals were vacuum dried for 24 hours. 72.2g of lutein crystal with 885 g/kg was obtained. 72.2g of the above lutein crystals and 155g of cyclic dextrin were mixed, and the lutein powder was obtained by grinding and crushing. The filtrate separated by the above centrifugation was neutralized and acidified by 4mol/l hydrochloric acid to a PH value of 6-6.5, and 612g of upper oil (lutein resin) with a content of 18 g/Kg was collected, with a total yield of 99.4%. |
| carotenoid | lutein is a kind of carotene, which belongs to photosynthetic pigment. it is naturally widely found in vegetables (such as spinach, cabbage, broccoli, etc.), flowers, fruits and other plants. it can transfer the absorbed light energy to chlorophyll a in a special state for converting light energy and has the function of protecting chlorophyll. The pure product is prismatic yellow crystals with metallic luster, unstable to light and hydrogen, insoluble in water, and easily soluble in grease and fatty solvents. Store in a cool and dry place, sealed from light. lutein is the most important nutrient of human retina. There is a high concentration of lutein in the macula (vision center) and lens of the retina of the eye, and the human body cannot synthesize it by itself. It must be absorbed by food, and then break through the difficulties, enter the lens and macula of the retina, and exert Antioxidant effect, neutralize harmful free radicals, filter out blue light that is destructive to the eyes, and avoid oxidative damage caused by light to the eyes. Natural lutein is an excellent antioxidant. Adding an appropriate amount to food can prevent cell aging and organ aging, and it can also prevent vision loss and blindness caused by age-related ocular retinal macular degeneration. At the same time, it can also be used as a feed additive for the coloring of poultry meat and eggs, and as a coloring and nutritional health agent in the food industry. Carotenoids are a general term for a class of important natural pigments and belong to compounds. The yellow, orange-red or red pigments commonly found in animals, higher plants, fungi, algae and bacteria, mainly β-carotene and a-carotene, hence the name. Since carotene was isolated in the early 19th century, it is currently known that there are more than 600 carotenoids in nature, of which only about 20 are found in human blood and tissues. Carotenoids found in the human body mainly include D-carotene, P-carrot, cryptoxanin, lutein, lycopene and zeaxanthin, insoluble in water, soluble in fat and fat solvents. |
| those foods are rich in lutein? | lutein is high in some green vegetables and fruits such as cabbage, spinach, lettuce, mung bean and rape, but this kind of plants also contain more chlorophyll, β-carotene and other carotenoid epoxy and oxo derivatives, which are not easy to extract pure products. After long-term search, people found that the content of lutein and zeaxanthin in marigold flowers is extremely high, and other carrot I-element impurities are less, easy to separate and purify, and can be used as a good source of industrial production. In addition, some yellow-orange fruits such as mango, papaya, peach, pumpkin, etc. are also rich in this product and zeaxanthin. |
| effect | protect vision: lutein has an important protective effect on macula in retina, and is easy to cause macular degeneration and blurred vision when lacking. Then there are symptoms such as vision deterioration and myopia. Lutein is the precursor of NA and can be converted into VA in the human body. The main physiological function of lutein on the eye is as an antioxidant and photoprotective effect. The optic nerve is not renewable and is extremely vulnerable to harmful free radicals. The antioxidant effect of lutein can inhibit the formation of harmful free radicals. Lutein can absorb a large amount of blue light. The wavelength of blue visible light is close to that of ultraviolet light, which is the most potentially harmful light in visible light that can reach the retina. Before reaching the sensitive cells on the retina, the light passes through the highest concentration area of lutein. At this time, if the lutein content in the macula is abundant, the damage can be minimized. The effect of anti-oxygen lutein has a strong oxidation effect, which can inhibit the activity of reactive oxygen radicals and prevent the damage of reactive oxygen radicals to normal cells. Relevant experiments have proved that reactive oxygen radicals can react with DNA, proteins and lipids to weaken their physiological functions, thus causing the occurrence of chronic diseases such as cancer, arteriosclerosis and aging yellow magic degeneration. Lutein can inactivate singlet oxygen through physical or chemical quenching, thereby protecting the body from harm and enhancing the body's immunity. Reduce the incidence of cataracts Cataract is the main eye disease that causes blindness worldwide. The latest research proves that the birth rate can be achieved by increasing the intake of lutein. It is currently believed that its mechanism is lower macular pigment density and middle-aged and elderly People's higher lens visual density is closely related, and higher lens visual density is considered to be an obvious feature of cataract. |
| delaying arteriosclerosis and anticancer effect | delaying arteriosclerosis effect Recent research results show that lutein has a delaying effect on the early arteriosclerosis process. It is mainly the relationship between the change of intima thickness of arterial artery and the content of lutein in blood. The low content of lutein in blood can easily cause arterial wall thickening. With the gradual increase of lutein content, the trend of arterial wall thickening decreases, and arterial embolism also significantly decreases. At the same time, the leaf yellow in the arterial wall cells can also reduce the oxidation of LDL cholesterol. Many studies have shown that lutein has inhibitory effects on various cancers, such as breast cancer, prostate cancer, rectal cancer, skin cancer, etc. According to a recent study by the School of Medicine of New York University, there is a close relationship between reducing the incidence of breast cancer and the intake of lutein. The survey found that the incidence of breast cancer in the experimental group with low intake of lutein was higher than that in the group with high intake (2.08~2.21) times. This effect may involve indirect immunomodulatory effects in coordination with other organs and tissues. The study concluded that taking lutein in the diet can not only inhibit tumor and even prevent tumor occurrence. Relevant agencies suggest that per capita daily intake of 400 g ~ 600 g of fruits and vegetables can reduce the relative risk of cancer by 50%. |
| identification test | solubility insoluble in water, soluble in hexane. Spectroscopic determination of chloroform solution has maximum absorption at about 445nm. Chloroform solution When the excess Cart-Price test solution is added, the color turns to blue. |
| toxicity | ADI has not yet been specified (FAO/WHO,2001). |
| who needs lutein supplement? | 1. Long-term use of computer workers 2. Dry eye symptoms 3. Eyes are prone to fatigue and tears 4. Retinal degeneration caused by renal function degeneration 5. High myopia 6. Degenerative macular area disease 7. Those who have received myopia laser 8. Diabetic retinopathy |
| use | used in papermaking, printing and dyeing industries can be used for food coloring or added to poultry feed to enhance yellow egg yolk food coloring. [application] lutein has the characteristics of "natural", "nutrition" and "multi-function", and can be widely used in food, health care products, cosmetics, medicine and feed additives. diet carotene, but it does not vitamin the effect of a, increases the pigment concentration of spots in eyes, and may improve vision. |
| Production method | It is obtained by extracting pasture or alfalfa with solvent, saponification to remove chlorophyll, and then purifying with solvent and dissolving. The solvent used is limited to methanol, ethanol, isopropanol, hexane, acetone, dichloromethane and methyl ethyl ketone according to FAO/WHO(1997). |
Last Update：2024-04-09 21:54:55
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Mobile: +86 13875855783
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