beta-Hydroxypropiosyringone

beta-Hydroxypropiosyringone - Names and Identifiers

Name	3,4'-Dihydroxy-3',5'-dimethoxypropiophenone
Synonyms	beta-Hydroxypropiosyringone 3,4'-Dihydroxy-3',5'-dimethoxypropiophenone 3,4'-Dihydroxy-3',5'-diMethoxypropiophenone 3-Hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)propan-1-one 3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-propanone 1-Propanone, 3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-
CAS	136196-47-9

beta-Hydroxypropiosyringone - Physico-chemical Properties

Molecular Formula	C11H14O5
Molar Mass	226.23
Density	1.247±0.06 g/cm3(Predicted)
Melting Point	74-75 °C
Boling Point	426.9±45.0 °C(Predicted)
Appearance	Powder
pKa	8.14±0.25(Predicted)
Storage Condition	2-8℃

beta-Hydroxypropiosyringone - Introduction

3,4 '-Dihydroxy-3',5 '-dimethoxypiophenone, also known as 3,4'-Dihydroxy-3 ',5'-dimethoxypropanedione, chemical formula C13H16O5.

Nature:
3,4 '-Dihydroxy-3',5 '-dimethoxypiophenone is a white crystalline solid. It has a melting point and a boiling point, with a melting point of about 136-138 ° C. It is stable at room temperature, but may decompose under light conditions. It is soluble in organic solvents such as ethanol, dimethylsulfoxide and dimethylformamide.

Use:
3,4 '-Dihydroxy-3',5 '-dimethoxypropiophenone can be used as an important intermediate in organic synthesis. It is commonly used in the synthesis of drugs, dyes and other chemicals. It has been used in the pharmaceutical field to synthesize the anticancer agent Tozemetostat, etc.

Method:
3,4 '-Dihydroxy-3',5 '-dimethoxypiophenone can be prepared by acylation of toluene and then hydroxylation. The specific steps include reacting toluene and acetone to produce 3-hydroxy-1-(4-methylphenyl) propan-1-one. This intermediate is then converted to 3-hydroxy-1-(4-bromophenyl) propan-1-one by treatment with bromine. Finally, 4-hydroxy-3, 5-dimethoxybenzoborate was reacted with sodium hydride to give 3,4 '-Dihydroxy-3',5 '-dimethoxypiophenone.

Safety Information:
According to currently available information, 3,4 '-Dihydroxy-3',5 '-dimethoxypiophenone has no obvious hazard and toxicity reports under normal use conditions. However, as with all chemicals, safe practices should be followed, including wearing appropriate personal protective equipment and maintaining good ventilation. Specific safety data and toxicity information need to be confirmed according to the material safety data sheet provided by the supplier or relevant literature.

Last Update：2024-04-09 21:00:56