beta-methylacetylcholinechloride
METHACHOLINE CHLORIDE
CAS: 62-51-1
Molecular Formula: C8H18ClNO2
beta-methylacetylcholinechloride - Names and Identifiers
beta-methylacetylcholinechloride - Physico-chemical Properties
| Molecular Formula | C8H18ClNO2 |
| Molar Mass | 195.69 |
| Density | 1.1028 (rough estimate) |
| Melting Point | 171-173 °C(lit.) |
| Water Solubility | almost transparency |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.579 |
| MDL | MFCD00011817 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
beta-methylacetylcholinechloride - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
beta-methylacetylcholinechloride - A new crystal form of methacholine chloride and its preparation method [patent]
from Baidu Library
Application (patent) number:
CN201811120808.8
application date:
2018-09-26
Public/Announcement Number:
CN110950767A
Public/announcement date:
2020.04.03
applicant (patent):
Beijing Ted Pharmaceutical Co., Ltd.
inventor:
Guo Guangzhu , Qin Jianzheng , Zhang Bin , Li Wenming , Yang Rifang
National and provincial code:
CN110115
Abstract:
The invention relates to the technical field of drug crystal forms, in particular to a new crystal form of methacholine chloride and a preparation method thereof. The new crystalline form of methacholine chloride has characteristic peaks at 0.2 °, 32.68 ° and 33.90 ° in its X-ray powder diffraction pattern, expressed as 2 & theta;± 43.08 °. The preparation method comprises the following steps: Mixing the crude methacholine chloride with ethanol, heating to 6075 ° C. To dissolve the crude methacholine chloride, adding ethyl acetate A, and filtering to collect the filtrate; the filtrate was cooled, ethyl acetate B was added, filtered, and the filter cake was collected and dried. The new crystal form is flaky, is not easy to absorb moisture and agglomerate, has uniform particle size and greatly improved stability, and overcomes the fact that methacholine chloride is extremely easy to be wet and has very strict temperature control in production conditions, the defects such as powder filling can be directly carried out by crushing, which is beneficial to the preservation and subsequent production of the preparation and improves the convenience.
Last Update：2024-01-02 23:10:35
beta-methylacetylcholinechloride - Comparison of 10% sodium chloride and methacholine chloride in determination of airway responsiveness
from VIP
Author:
Zhou yi , Zhao Jiwen , Golden Flower , Guo Qingyun
Abstract:
Abstract:
Key words:
methacholine chloride airway responsiveness hypertonic saline sodium chloride airway hyperresponsiveness activator Respiratory resistance allergic rhinitis variant asthma bronchial asthma
DOI:
CNKI:SUN:LCFK.0.2000-01-014
year:
2000
Last Update：2023-08-16 22:09:50
beta-methylacetylcholinechloride - Concentration analysis of methacholine chloride aerosol by UHPLC-MS/MS
from VIP Journal Professional Edition
Author:
Zhu Di Feng , Zhao Jianlan , Hong , Qian renyun , Chen Chao , Pingli
Abstract:
An ultra performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-MS/MS) method was developed for the determination of methacholine chloride aerosol in inhalation devices. The chromatographic column was an acquisition BEH C_(18)(2.1 × 100, 1.7 μm) column, and 0.1% formic acid water and acetonitrile were used as the mobile phase for gradient elution at a flow rate of 0.3 mL/min, the sample volume was 5 μL, the analysis time was 5 min, the column temperature was 40 ℃, and the multiple reaction monitoring (MRM) positive ion mode was determined. At the same time, the specificity, linearity, instrument precision, standard recovery rate, extraction recovery rate and stability were investigated. The results showed that the calibration curve of methacholine chloride was linear within the range of 10~100 ng/mL (r> 0.999), and the limit of quantitation was 10 ng/mL; the average recovery of methacholine chloride aerosol was 99.2%, and the average relative standard deviation (RSD) was 0.80%. The average recovery of methacholine chloride aerosol was 95.7%. After nebulization in the inhalation exposure device for 1 min, the average drug concentration of the aerosol was 608.1 mg/m ^(3), and the RSD of the upper, middle and lower positions was 1.2%, the results showed that the aerosol concentration of methacholine chloride was uniform within 1 min of nebulization. The method has high sensitivity and good precision, which is suitable for the concentration determination of methacholine chloride aerosol. It can also provide a reference for the analysis of aerosol samples for inhalation.expand
Key words:
ultra performance liquid chromatography-tandem mass spectrometry methacholine chloride nebulized aerosol inhaled formulation
year:
2021
Last Update：2023-08-16 22:09:50
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