bis(2-hydroxybenzylidene)acetone
(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)
CAS: 131359-24-5
Molecular Formula: C17H14O3
bis(2-hydroxybenzylidene)acetone - Names and Identifiers
bis(2-hydroxybenzylidene)acetone - Physico-chemical Properties
| Molecular Formula | C17H14O3 |
| Molar Mass | 266.29 |
| Solubility | DMSO: soluble15mg/mL (clear solution) |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10. |
bis(2-hydroxybenzylidene)acetone - Risk and Safety
| WGK Germany | 3 |
bis(2-hydroxybenzylidene)acetone - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.755 ml | 18.777 ml | 37.553 ml |
| 5 mM | 0.751 ml | 3.755 ml | 7.511 ml |
| 10 mM | 0.376 ml | 1.878 ml | 3.755 ml |
| 5 mM | 0.075 ml | 0.376 ml | 0.751 ml |
Last Update：2024-01-02 23:10:35
bis(2-hydroxybenzylidene)acetone - Reference Information
| biological activity | 2-HBA is an effective NAD(P)H: quinone receptor oxidoreductase 1 (NQO1) inducer, can also activate caspase-3 (caspase-3) and caspase-10 (caspase-10). |
| target | Caspase-3 Caspase-10 |
| in vitro study | When L1210 cells are exposed to 0.6 μM 2-HBA (bis(2-hydroxy-benzylidene)acetone), the specific activities of NQO1 and glutathione reductase increase by 6- and 1.5-fold, respectively. The total cellular glutathione content is also coordinately induced by 2.4-fold. In a more detailed study it is found that NQO1 is induced by 2-HBA in a concentration-dependent manner. Treatments with 2-HBA cause cell cycle arrest and apoptosis in both L1210 wild type cells and their Y8 drug-resistant counterparts in a concentration-dependent manner. 2-HBA can also activate caspase-3 and caspase-10. |
Last Update：2024-04-09 01:59:59
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Spot supply
Product Name: (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) Visit Supplier Webpage Request for quotationCAS: 131359-24-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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