bm06002
Imexon
CAS: 59643-91-3
Molecular Formula: C4H5N3O
bm06002 - Names and Identifiers
bm06002 - Physico-chemical Properties
| Molecular Formula | C4H5N3O |
| Molar Mass | 111.1 |
| Density | 2.26±0.1 g/cm3(Predicted) |
| Boling Point | 231.6±23.0 °C(Predicted) |
| pKa | 4.79±0.20(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | Imexon (BM 06002) induces oxidative stress in the ER, activates an ER stress response. Imexon (BM 06002) does not significantly alter the levels of eIF2B5, however there is a dose-dependent increase in the phosphorylation of eIF2alpha, as well as an increase in the levels of GTP exchange protein eIF2B2 in MiaPaCa-2, Panc-1, and BxPC3 cells. Imexon (BM 06002) induces single-stranded breaks in the human A375 melanoma cells but only significantly at the highest concentrations for each agent compared to controls. Imexon plus DTIC cytotoxicity is additive. Imexon (BM 06002) show inhibitory activities against MiaPaCa-2, Panc-1 and BxPC3, with IC 50 s of 275.5 ± 54.2, 147.4 ± 4.7 and 355.7 ± 114.7 μM. |
| In vivo study | Imexon (BM 06002) in combination with DTIC results in an increase in the peak plasma imexon level in non-tumor-bearing mice. The combination of both drugs increases plasma imexon AUC by 22% (p=0.026). Imexon (BM 06002) (100 mg/kg/day, i.v.) treatment decreases the body weight of SCID mice bearing human A375 melanoma tumors, but there is no significant difference in tumor growth. Imexon (BM 06002) (100 mg/kg) in combination with GEM shows synergistic inhibition of Panc-1 tumor growth in SCID mice. |
bm06002 - Risk and Safety
| WGK Germany | 3 |
bm06002 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 9.001 ml | 45.005 ml | 90.009 ml |
| 5 mM | 1.8 ml | 9.001 ml | 18.002 ml |
| 10 mM | 0.9 ml | 4.5 ml | 9.001 ml |
| 5 mM | 0.18 ml | 0.9 ml | 1.8 ml |
Last Update：2024-01-02 23:10:35
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Product Name: Imexon Visit Supplier Webpage Request for quotation
CAS: 59643-91-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 59643-91-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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