bromo-4-methoxypyridine
2-Bromo-4-methoxypyridine
CAS: 89488-29-9
Molecular Formula: C6H6BrNO
bromo-4-methoxypyridine - Names and Identifiers
| Name | 2-Bromo-4-methoxypyridine |
| Synonyms | bromo-4-methoxypyridine 2-Bromo-4-methoxypyridine Pyridine,2-bromo-4-methoxy- |
| CAS | 89488-29-9 |
bromo-4-methoxypyridine - Physico-chemical Properties
| Molecular Formula | C6H6BrNO |
| Molar Mass | 188.02 |
| Density | 1.530±0.06 g/cm3(Predicted) |
| Boling Point | 120-121 °C(Press: 10 Torr) |
| pKa | 2.10±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
bromo-4-methoxypyridine - Introduction
2-Bromo-4-methoxypyridine is an organic compound with the chemical formula C6H6BrNO. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless to light yellow liquid
-Molecular weight: 187.02g/mol
-Melting point:-40°C
-Boiling Point: 215-217°C
-Density: 1.527g/cm³
-Solubility: Soluble in organic solvents such as ethanol and acetone
Use:
- 2-Bromo-4-methoxypyridine has an important role as an intermediate and reagent, and is widely used in the field of organic synthesis.
-can be used as intermediates in the field of medicine, pesticides and cosmetics.
Preparation Method:
The preparation method of 2-Bromo-4-methoxypyridine can be carried out by the following steps:
1. Methylpyridine is treated as 2,1-dichloromethylpyridine.
2. In the presence of hydrofluoric acid, 2-bromo -4-chloromethylpyridine is prepared by bromo -2,1-dichloromethylpyridine.
3. Reaction of sodium hydroxide with nitrous acid to replace chlorine atom with hydroxyl group to obtain 2-bromo-4-hydroxymethylpyridine.
4. Finally, 2-Bromo-4-methoxypyridine was prepared by reacting methyl iodide to replace the hydroxyl group with methoxy group.
Safety Information:
- 2-Bromo-4-methoxypyridine has no obvious danger under normal use conditions. But as a chemical substance, still need to pay attention to the following safety matters:
-Avoid inhaling its vapor or dust, avoid contact with skin and eyes.
-Use personal protective equipment such as gloves, goggles and lab coats when used.
-It should be operated in a well-ventilated place and stored properly, away from fire and oxidizing agents.
-If taken by mistake or inhaled, seek medical attention immediately and bring the product label and safety data sheet with you.
Nature:
-Appearance: Colorless to light yellow liquid
-Molecular weight: 187.02g/mol
-Melting point:-40°C
-Boiling Point: 215-217°C
-Density: 1.527g/cm³
-Solubility: Soluble in organic solvents such as ethanol and acetone
Use:
- 2-Bromo-4-methoxypyridine has an important role as an intermediate and reagent, and is widely used in the field of organic synthesis.
-can be used as intermediates in the field of medicine, pesticides and cosmetics.
Preparation Method:
The preparation method of 2-Bromo-4-methoxypyridine can be carried out by the following steps:
1. Methylpyridine is treated as 2,1-dichloromethylpyridine.
2. In the presence of hydrofluoric acid, 2-bromo -4-chloromethylpyridine is prepared by bromo -2,1-dichloromethylpyridine.
3. Reaction of sodium hydroxide with nitrous acid to replace chlorine atom with hydroxyl group to obtain 2-bromo-4-hydroxymethylpyridine.
4. Finally, 2-Bromo-4-methoxypyridine was prepared by reacting methyl iodide to replace the hydroxyl group with methoxy group.
Safety Information:
- 2-Bromo-4-methoxypyridine has no obvious danger under normal use conditions. But as a chemical substance, still need to pay attention to the following safety matters:
-Avoid inhaling its vapor or dust, avoid contact with skin and eyes.
-Use personal protective equipment such as gloves, goggles and lab coats when used.
-It should be operated in a well-ventilated place and stored properly, away from fire and oxidizing agents.
-If taken by mistake or inhaled, seek medical attention immediately and bring the product label and safety data sheet with you.
Last Update：2024-04-09 21:00:56
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CAS: 89488-29-9
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QQ: 3008007409
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CAS: 89488-29-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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