c(CRGDKGPDC)

Name	iRGD
Synonyms	iRGD iRGD TFA c(CRGDKGPDC) iRGD peptide TFA salt L-Cysteine, L-cysteinyl-L-arginylglycyl-L-α-aspartyl-L-lysylglycyl-L-prolyl-L-α-aspartyl-, cyclic (1→9)-disulfide
CAS	1392278-76-0

Molecular Formula	C35H57N13O14S2
Molar Mass	948.04
Density	1.68±0.1 g/cm3(Predicted)
pKa	2.92±0.70(Predicted)
Storage Condition	Room Temprature
In vitro study	iRGD peptide-mediated tumor penetration occurs in three steps: binding to αv-integrins on tumor vasculature or tumor cells, exposure by proteolysis of a C-terminal motif that binds to neuropilin-1 (NRP-1) and cell internalization. iRGD peptide inserted in the ICOVIR15K fiber C terminus enhances binding and internalization only in MCF7 cells, which express NRP-1 and integrins. iRGD insertion does not impair virus infection and replication. iRGD peptide alone has no obvious effect on gastric cancer cells, and when combined with 5-FU, iRGD peptide (0.3 μmol/mL) enhances the chemotherapy efficacy of 5-FU on gastric cancer cells through NRP1.
In vivo study	iRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice. iRGD (4 mmol/kg, i.v.) in combination with 5-FU significantly suppresses the tumor growth in nude mice bearing human gastric cancer cells.

biological activity	iRGD peptide is a cyclic peptide consisting of 9 amino acids, the subsequent enzymatic hydrolysis results in the interaction between CRGDK/R and neuropilin-1 (neuropilin-1), thereby promoting the tissue penetration of the drug, which has the effect of targeting tumor and tumor penetration.
Target	Integrin

Last Update：2024-04-09 02:00:15

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CAS: 1392278-76-0
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Product Name: iRGD Visit Supplier Webpage Request for quotation
CAS: 1392278-76-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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c(CRGDKGPDC)

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