c-di-AMP
c-di-AMP
CAS: 54447-84-6
Molecular Formula: C20H24N10O12P2
c-di-AMP - Names and Identifiers
| Name | c-di-AMP |
| Synonyms | di-AMP di-cAMP c-di-AMP Cyclic-di-AMP Cyclic diadenylate Cyclic di-3',5'-adenylate c-di-AMP (Cyclic diadenylate 3'-Adenylic acid, adenylyl-(3'→5')-, cyclic nucleotide |
| CAS | 54447-84-6 |
c-di-AMP - Physico-chemical Properties
| Molecular Formula | C20H24N10O12P2 |
| Molar Mass | 658.411884 |
| Density | 2.52±0.1 g/cm3(Predicted) |
| Boling Point | 1096.7±75.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | powder |
| Color | white to beige |
| pKa | 0.96±0.70(Predicted) |
| Storage Condition | -20°C |
c-di-AMP - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.519 ml | 7.594 ml | 15.188 ml |
| 5 mM | 0.304 ml | 1.519 ml | 3.038 ml |
| 10 mM | 0.152 ml | 0.759 ml | 1.519 ml |
| 5 mM | 0.03 ml | 0.152 ml | 0.304 ml |
Last Update：2024-01-02 23:10:35
c-di-AMP - Introduction
Biological activity
c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to STING to activate the TBK3-IRF3 signaling pathway, which subsequently triggers the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is a bacterial second messenger, mainly in Gram-positive bacteria, which can regulate cell growth, survival and virulence. c-di-AMP (Cyclic diadenylate) also regulates the host immune response. c-di-AMP (Cyclic diadenylate) can be used as an effective mucosal adjuvant to stimulate body fluid and cell responses.
Target
STING
In vitro studies
c-di-AMP (Cyclic diadenylate) signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria including S. aureus , L. monocytogenes , S. pyogenes , and Mycobacterium spp .
c-di-AMP (Cyclic diadenylate) combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
Last Update：2024-04-10 22:29:15
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CAS: 54447-84-6
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CAS: 54447-84-6
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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