carbocisteine
Carboxymethylcysteine
CAS: 638-23-3;186537-58-6;2387-59-9
Molecular Formula: C5H9NO4S
carbocisteine - Names and Identifiers
carbocisteine - Physico-chemical Properties
| Molecular Formula | C5H9NO4S |
| Molar Mass | 179.19 |
| Density | 1.315 (estimate) |
| Melting Point | 208-213°C (dec.) |
| Boling Point | 417.3±45.0 °C(Predicted) |
| Specific Rotation(α) | -31 º (c=1, 10% NaH2CO3) |
| Flash Point | 191.8°C |
| Water Solubility | SOLUBLE IN COLD WATER |
| Solubility | Aqueous Acid, Aqueous Base (Sparingly, Sonicated) |
| Vapor Presure | 2.74E-07mmHg at 25°C |
| Appearance | White crystal |
| Color | White to slightly off-white |
| Merck | 14,1802 |
| BRN | 1725012 |
| pKa | 2.06±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5216 (estimate) |
| MDL | MFCD00002614 |
| Physical and Chemical Properties | Melting point 205-207°C specific optical rotation -31 ° (c = 1, 10% NaH2CO3) WATER-SOLUBLE SOLUBLE IN COLD WATER |
| Use | Mainly used for chronic bronchitis, bronchial asthma and other diseases caused by sputum viscous, Expectoration difficult and sputum obstruction of the trachea and other diseases |
carbocisteine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
| RTECS | AY4342000 |
| TSCA | Yes |
| HS Code | 29309090 |
| Toxicity | LD50 oral in rat: > 15gm/kg |
carbocisteine - Upstream Downstream Industry
| Raw Materials | L-Cysteine |
| Downstream Products | Carbocistein |
carbocisteine - Nature
| melting point | 205.5°C |
| density | 1.315 (estimate) |
| refractive index | 1.5216 (estimate) |
| morphology | solid |
Last Update：2024-04-10 22:29:15
carbocisteine - Uses and synthesis methods
pharmacological action and mechanism of action
Carbocisteine is a respiratory tract phlegm dissolving agent. The effect is similar to bromhexine. The mechanism of action is to cleave the mucin disulfide bond in the sputum, thereby reducing the viscosity of the sputum, and can increase the mucus fiber in the sputum, lubricate the inner wall of the bronchus, and make the low-viscosity salivary mucin The secretion of protein increases and the production of high-viscosity fucoidan is reduced, which reduces the viscosity of sputum and is easy to cough up.
indications
Carboxymethyl Stan is a mucus regulator, which mainly affects the secretion of bronchial glands at the cellular level, increasing the secretion of low-viscosity salivary mucin, while the production of high-viscosity fucoidan is reduced, thus reducing the viscosity of sputum., Easy to cough out. Used for chronic bronchitis, bronchial asthma and other diseases caused by thick sputum, difficult expectoration and sputum blocking the trachea.
precautions
1. ask in detail whether there is a history of ulcer disease. closely observe whether there is black stool in stool during taking medicine. patients with bleeding tendency of stomach and 12-finger intestinal ulcer should be used with caution. this medicine should be kept in a cool and dry place.
2. Patients with heart and liver insufficiency and peptic ulcer should be used with caution, and it is not suitable for pregnant women.
drug interactions
1. Avoid taking strong antitussive drugs at the same time to prevent sputum from blocking the airway.
2. If drug interaction may occur with other drugs, please consult your physician or pharmacist for details.
use
Mainly used for the treatment of sputum viscosity, difficulty in expectoration and sputum obstruction of the trachea caused by chronic bronchitis, bronchial asthma and other diseases
production method
It is prepared by condensation of L-cysteine hydrochloride and chloroacetic acid.
Last Update：2024-04-09 15:16:15
carbocisteine - Introduction
Carboxymethylcysteine is an amino acid containing a carboxyl group and a sulfhydryl group. Its molecular formula is C4H7NO3S, structural formula is H2NCH2SCH2COOH.
Nature:
Carboxymethylcysteine is a colorless to white crystalline powder with a special odor. It has good solubility in water and is soluble in alcohols and ketones.
Use:
Carboxymethylcysteine is widely used in the fields of medicine, food, cosmetics and skin care products. It can promote the metabolism and repair of skin cells, with antioxidant, moisturizing and whitening effect. In addition, it can also be used to produce health products and protein emulsifiers.
Preparation Method:
Carboxymethylcysteine is generally synthesized by the reaction of thiol group and carboxyl group. Commonly used preparation methods include thiol reaction, dehydration reaction and esterification.
Safety Information:
Carboxymethylcysteine is generally considered to be a relatively safe substance, but the following matters still need to be paid attention:
1. Contact should pay attention to protective measures, such as wearing gloves and goggles.
2. Avoid inhaling dust and avoid direct contact with skin and eyes.
3. If ingested or inhaled overdose, should immediately seek medical advice and consult a professional doctor.
4. In storage and handling, should comply with the relevant safety procedures.
Please note that all chemicals should be used in accordance with proper laboratory procedures and safety measures.
Nature:
Carboxymethylcysteine is a colorless to white crystalline powder with a special odor. It has good solubility in water and is soluble in alcohols and ketones.
Use:
Carboxymethylcysteine is widely used in the fields of medicine, food, cosmetics and skin care products. It can promote the metabolism and repair of skin cells, with antioxidant, moisturizing and whitening effect. In addition, it can also be used to produce health products and protein emulsifiers.
Preparation Method:
Carboxymethylcysteine is generally synthesized by the reaction of thiol group and carboxyl group. Commonly used preparation methods include thiol reaction, dehydration reaction and esterification.
Safety Information:
Carboxymethylcysteine is generally considered to be a relatively safe substance, but the following matters still need to be paid attention:
1. Contact should pay attention to protective measures, such as wearing gloves and goggles.
2. Avoid inhaling dust and avoid direct contact with skin and eyes.
3. If ingested or inhaled overdose, should immediately seek medical advice and consult a professional doctor.
4. In storage and handling, should comply with the relevant safety procedures.
Please note that all chemicals should be used in accordance with proper laboratory procedures and safety measures.
Last Update：2024-04-09 20:52:54
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Raw Materials for carbocisteine
Downstream Products for carbocisteine