cremosuxidine

Name	Succinylsulfathiazole
Synonyms	SST kaoxidin KAOXIDINE colistatin sulfasuccinil sulfasuccidin cremosuxidine sulfasuccidine sulfasuccithiazole Succinylsulfathiazole 4-oxo-4-{[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]amino}butanoic acid
CAS	116-43-8
EINECS	204-141-0
InChI	InChI=1/C13H13N3O5S2/c17-11(5-6-12(18)19)15-9-1-3-10(4-2-9)23(20,21)16-13-14-7-8-22-13/h1-4,7-8H,5-6H2,(H,14,16)(H,15,17)(H,18,19)

Molecular Formula	C13H13N3O5S2
Molar Mass	355.39
Density	1.4807 (rough estimate)
Melting Point	193.5°C
Water Solubility	0.49g/L(38 ºC)
Solubility	1 M NaOH: soluble50mg/mL
Appearance	White powder
Color	white to off-white
Maximum wavelength(λmax)	['282nm(H2O (pH 3.3 - 5))(lit.)']
Merck	14,8877
BRN	349989
pKa	pKa 4.5 (Uncertain)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.6390 (estimate)
MDL	MFCD00022437

Hazard Symbols	Xn - Harmful
Risk Codes	42/43 - May cause sensitization by inhalation and skin contact.
Safety Description	S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	3249
WGK Germany	3
RTECS	WM4767000
HS Code	29350090
Hazard Class	6.1(b)
Packing Group	III

EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
use	succinyl sulfathiazole is a sulfonamide antibiotic that can inhibit bacteria that cause folic acid production. Succinylsulfamethiazole is used in the study of various folate deficiencies to prevent the synthesis of folate.
preparation	the manufacture of succinyl sulfathiazole is usually obtained by condensation of succinic anhydride and sulfathiazole in a dry organic solvent, with a yield of about 92%. the choice of solvent is hydrophilic solvent. Succinyl sulfathiazole can also be synthesized by solid phase, and the starting material is still succinic anhydride and sulfathiazole. Solid phase synthesis is much better than solvent condensation. The advantages are as follows: 1. No organic solvent is required; 2. Simple equipment and easy operation; 3. Safety; 4. High yield and low cost; 5. The difference between the starting material succinic anhydride and sulfathiazole is small. The preparation reaction formula is as follows: fig. 1 succinyl sulfamethiazole preparation reaction formula
biological activity	Succinylsulfathiazole (Succinylsulphathiazole) is a sulfonamide antibiotic.

Last Update：2024-04-09 20:52:54

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