cromolyn
Cromoglicic acid
CAS: 16110-51-3
Molecular Formula: C23H16O11
cromolyn - Names and Identifiers
cromolyn - Physico-chemical Properties
| Molecular Formula | C23H16O11 |
| Molar Mass | 468.37 |
| Density | 1.623 |
| Melting Point | 241-242°C |
| Boling Point | 752.3±60.0 °C(Predicted) |
| pKa | pKa 2.0 (Uncertain) |
| Storage Condition | 2-8°C |
cromolyn - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| RTECS | DJ2380000 |
cromolyn - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| sodium cromoglycate | white crystalline powder, hygroscopic, odorless, initially tasteless, slightly bitter after. It is easy to change color in case of light. Soluble in water (1:20), insoluble in ethanol, chloroform, ether. The pH of the aqueous solution was 4~7. sodium cromoglycate, also known as disodium cromoglycinate, thiophanone, ketolide sodium, ningmin, cromolyn acid, Yantai, is a preventive anti-allergic drug, for immediate type (reactive type) allergic reactions have a good role in the prevention and treatment. Its mechanism of action is through the inhibition of intracellular cyclic adenosine monophosphate phosphodiesterase, resulting in an increase in the concentration of intracellular cyclic adenosine monophosphate (cAMP), prevent calcium transport into mast cells, thereby stabilizing the cell membrane of mast cells, it prevents the degranulation of mast cells, inhibits the release of allergic reaction mediators such as histamine, serotonin and slow reaction substances, and further inhibits the adverse effects of allergic reaction mediators on tissues. it is rarely absorbed after oral administration, and the intestinal absorption is only 1%. After dry powder spray inhalation, 50% ~ 80% is deposited in the oral cavity and throat, only about 8% is absorbed into the blood through the lungs and gastrointestinal tract. Lung absorption is rapid, inhaled 15~20 minutes after the peak blood concentration, half-life of 1~1.5 hours, plasma protein binding rate of about 70%, not through the placenta. The urine and bile in the shape of the discharge of 50%. cromolyn sodium is used to prevent the onset of allergic bronchial asthma. It has a good effect on exogenous asthma with known allergens, especially in adolescent patients. It is also used for allergic rhinitis and seasonal hay fever. Oral and enema for ulcerative colitis, ulcerative proctitis, Ointment for chronic allergic eczema and some skin pruritus, 2% eye drops for hay fever, conjunctivitis and spring cornea, conjunctivitis. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:49:11
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View History
cromolyn
234076-12-1
Wheat gern oil
19210-21-0
氯[1,3-双(2,4,6-三甲基苯基)2H-咪唑-2-亚立德]金(I)
4-(bromomethyl)benzophenone
3-Cyano-6-(trifluoromethyl)pyrid-2-one
70657-70-4
915810-67-2
2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-chromen-4-one
234076-12-1
Wheat gern oil
19210-21-0
氯[1,3-双(2,4,6-三甲基苯基)2H-咪唑-2-亚立德]金(I)
4-(bromomethyl)benzophenone
3-Cyano-6-(trifluoromethyl)pyrid-2-one
70657-70-4
915810-67-2
2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-chromen-4-one