d-pantothenicaci
D-PANTOTHENIC ACID
CAS: 79-83-4
Molecular Formula: C9H17NO5
d-pantothenicaci - Names and Identifiers
d-pantothenicaci - Physico-chemical Properties
| Molecular Formula | C9H17NO5 |
| Molar Mass | 219.24 |
| Density | 1.266 |
| Melting Point | 178-179℃ |
| Boling Point | 360.05°C (rough estimate) |
| Specific Rotation(α) | D25 +37.5° |
| pKa | 4.30±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4315 (estimate) |
| Physical and Chemical Properties | Colorless or light yellow viscous oily liquid. Easy to absorb moisture, unstable. Acid, alkali, heat can accelerate its decomposition. This product is difficult to dissolve in benzene, chloroform, slightly soluble in ether, pentanol, soluble in water, ethyl acetate, dioxane and acetic acid. |
| Use | Uses for feed additives, medicine and food additives. Sodium pantothenate is also used in beverage additives, but because of its strong hygroscopicity, pantothenic acid is now used instead. |
d-pantothenicaci - Risk and Safety
| Toxicity | LD50 intraperitoneal in mouse: 1443mg/kg |
d-pantothenicaci - Research progress in biological preparation of D-pantothenic acid
From VIP Journal Professional Edition
Author:
Sun Zhihao ,< a href = "https://xueshu.baidu.com/s?wd=author: (Tang Yixin) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Tang Yixin
Summary:
summarizes the research situation of D-pantothenic acid preparation by biological methods, mainly introduces the method of fermenting glucose to generate D-pantothenic acid, adding β-alanine, and directly fermenting to produce D-pantothenic acid; enzymatic conversion or resolution, especially asymmetric reduction of ketone-based pantothenic acid (or lactone), stereoselective hydrolysis resolution of DL-pantothenic acid, and commented on its development prospects.
keywords:
D-pantothenic acid pantothenic acid ketone pantothenic acid (or lactone)> fermentation enzymatic method split
DOI:
10.3969/j.issn.1005-8915.2002.03.015
cited:
Year:
2002
Last Update：2024-01-02 23:10:35
d-pantothenicaci - Screening and identification of D-pantothenic acid-producing strain C21
From HowNet
Author:
Li Dongsheng , Li Nana , Yang Weichao , Xu Hui
Summary:
315 rhizosphere microorganisms were isolated from 10 plant rhizosphere soil samples, and then 7 D-pantothenic acid producing strains were screened by pantothenic acid determination plate screening and shake flask screening. among them, strain C21 isolated from phaseolus bean rhizosphere soil had the highest D-pantothenic acid yield, reaching 24.1mg/L. Finally, through morphological, physiological and biochemical characteristics and 16SrDNA identification, strain C21 was determined to be Pseudomonas putida (Pseudomonas putida).
keywords:
Pseudomonas putida D-pantothenic acid rhizosphere microorganism identification
DOI:
10.3969/j.issn.1005-7021.2010.03.007
cited:
Year:
2010
Last Update：2023-08-16 22:09:50
d-pantothenicaci - A crystallization method of D-calcium pantothenate
from Baidu library
patent type:
patent for invention
application (patent) number:
CN202010876362.2
date of application:
20200827
public/announcement number:
CN111807980A
date of publication/announcement:
20201023
Applicant (patentee):
Anhui Tiger Biotechnology Co., Ltd
Inventor:
Wujiang , Zhou Duoxiang , Wang Honghu , Duan Xiaorui , Zhao yi ,< a href = "https://xueshu.baidu.com/s?wd=author: (sun suxin) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> sun suxin
national and provincial code:
CN340304
Summary:
The present invention relates to a crystallization method of D calcium pantothenate, which comprises the following steps:(1) taking anhydrous methanol, β aminopropanol and calcium oxide, fully reacting, filtering, and collecting filtrate;(3) Add water to the filtrate obtained in step (2) to 4-9% of the total mass of the crystalline solution, cool down to 5-10 ℃, and then hold the temperature and stir for crystallization. The method provided by the invention uses low-toxic organic solvent methanol, after the end of the acylation reaction to control the water content of the system and then low-temperature crystallization, and control the stirring speed, so as to ensure that the product quality is high, easy to centrifuge in the production process, the crystal type good solvent residue is low, good drying, good particle fluidity after drying, small dust. The method provided by the invention is easy to obtain, the condition is environmentally friendly and safe, the reaction time is short, and the production of calcium pantoate is solved.
Last Update：2023-08-16 22:09:50
d-pantothenicaci - A new process for the preparation of D-calcium pantothenate
from Baidu library
Application (Patent) No.:
CN202010407239.6
date of application:
2020-05-14
public/announcement number:
CN111518861A
date of publication/announcement:
2020.08.11
Applicant (patentee):
Wujiang
Inventor:
national and provincial code:
CN420111
Summary:
A new process for the preparation of D calcium pantothenate The present invention relates to a new process for the preparation of D calcium pantothenate. The basic scheme of the invention is: DL pan-lytic acid lactone is prepared into an aqueous solution with a content of 1626%, 515% biological enzyme of the mass of the aqueous solution is added, and after stirring is uniform, the aqueous solution containing D pan-lytic acid lactone 0.490.51 molar amount of calcium beta amino propionate content of 200% is slowly added dropwise at 2330 ℃. The reaction has been carried out until the hydrolysis of D pan-lytic acid lactone completely filters out the clear liquid, and the filter cake biological enzyme is recycled. The pH value of the reaction system was kept between 6.07.3 during the dropping process. After the reaction is completed, the clear liquid is concentrated to 115120 ℃ in a vacuum higher than 0.085MPa, cooled to below 65 ℃, adding methanol with a weight of 0.50.8 times d of calcium β aminopropionate, stirring and cooling to 2040 ℃, filtering, washing the filter cake with methanol, beating, and washing to realize purification
Last Update：2023-08-16 22:09:50
d-pantothenicaci - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | D-pantothenic acid is colorless or light yellow viscous oily liquid, easy to absorb moisture and unstable. Acid, alkali, and heat can accelerate its decomposition. It is hardly soluble in benzene and chloroform, slightly soluble in ether and pentanol, and easily soluble in water, ethyl acetate, dioxane and glacial acetic acid. |
| Physiological functions and effects | D-pantothenic acid is converted into coenzyme A(CoA) or acyl carrier protein (ACP) in vivo to participate in fatty acid metabolism. CoA is a cofactor of more than 70 enzymes in the organism (about 4% of the total enzyme content). Bacteria also need CoA to construct cell walls. In metabolism, CoA mainly plays the function of acyl carrier, participates in sugar, fat, protein and energy metabolism, and can also affect the location, stability and activity of protein by modifying protein. CoA provides 90% energy for organisms. Pantothenic acid is an essential substance for the synthesis of fatty acid steroids; it can also participate in the synthesis of steroid violet, melatonin and heme; it is also an intermediate necessary for the metabolism of citric acid circulation, choline acetylation, and synthetic antibodies in the body. Therefore, D-pantothenic acid can act on normal epithelial organs such as nerves, adrenal glands, digestive tract and skin in the body to improve the resistance of animals to pathogens. |
| application | D-pantothenic acid is widely used in biochemical research and drug research. |
| production method | because pantothenic acid has strong hygroscopicity and is difficult to crystallize, it is usually made into calcium salt and sodium salt. D-pantothenic acid also exists naturally and has physiological activity. It is composed of isobutyraldehyde and formaldehyde in the presence of potassium carbonate for aldol condensation, and then cyanidation and lactone into dl-pantotholactone, and then with aminopropionate Calcium reaction.. Because pantothenic acid has strong hygroscopicity and is difficult to crystallize, it is usually made into calcium salt and sodium salt. D-pantothenic acid also exists naturally and has physiological activity. For its industrial production methods, please refer to calcium pantothenate strips. It is prepared by the reaction of calcium and sulfuric acid. |
| use | biochemical research and drug research. used in feed additives, medicine and food additives. Sodium pantothenate is also used in beverage additives, but it has strong hygroscopicity. Now it is used to pantothenic acid. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 19:05:07
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