dT
Thymidine
CAS: 50-89-5;157049-39-3
Molecular Formula: C10H14N2O5
dT - Names and Identifiers
dT - Physico-chemical Properties
| Molecular Formula | C10H14N2O5 |
| Molar Mass | 242.23 |
| Density | 1.3129 (rough estimate) |
| Melting Point | 186-188°C(lit.) |
| Boling Point | 385.05°C (rough estimate) |
| Specific Rotation(α) | 18.6 º (c=3, H2O) |
| Water Solubility | SOLUBLE |
| Solubility | Acetone, DMSO (Slightly), Ethanol, Ethyl Acetate, Methanol (Slightly, Heated), P |
| Appearance | White crystalline powder |
| Color | White to almost white |
| Merck | 14,9397 |
| BRN | 89285 |
| pKa | pK1:9.79;pK2:12.85 (25°C) |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Sensitive to light |
| Refractive Index | 33 ° (C=1, 1mol/L Na |
| MDL | MFCD00006537 |
| Physical and Chemical Properties | White needle Crystal, soluble in methanol, ethanol, DMSO and other organic solvents. |
| Use | Used as a pharmaceutical intermediate for the synthesis of antiviral and anti-HIV drugs |
dT - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R40 - Limited evidence of a carcinogenic effect R36/37/38 - Irritating to eyes, respiratory system and skin. R68 - Possible risk of irreversible effects |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| WGK Germany | 3 |
| RTECS | XP2071000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| HS Code | 29335990 |
dT - Reference
| Reference Show more | 1. Gao Kun, Gong, Rui Ze, Li Shanshan, et al. Simultaneous determination of 13 nucleosides in ginseng by UPLC [J]. Food Industry 2019. 2. Xie Zhen, GE Shujun. Determination of four nucleosides and trigonelline in Pinellia palmatum from different habitats [J]. Chinese herbal medicine 2017 v.40;No.406(12):85-88. 3. Liu Zhengbo, Zhang yayuwang, Qiuxia et al. Effects of different potassium levels on the contents of nucleosides in panax ginseng [J]. Journal of Jilin Agricultural University, 2019, 41(4):432-437. 4. Li Xuelin, Wang Kehan, Kang Huan, Shi Junhan, Wang Qingxiao, Gui Xinjing, Zhang Lu, Zhang Yao, Wang Yanli, Feng Wenhao, Zhang Pu, Yao Jing, Liu Ruixin. Comparative study of cortex phellodendri formula granule decoction, standard decoction and traditional decoction based on HPLC fingerprint [J]. Chinese herbal medicine, 2020,51(01):91-100. 5. Wen Jie Zhang, Shi Gang Liu, Lei Han, Hong Qun Luo, Nian Bing Li,A ratiometric fluorescent and colorimetric dual-signal sensing platform based on N-doped carbon dots for selective and sensitive detection of copper(II) and pyrophosphate ion,Sensors and Ac 6. Wang, Chengcheng, et al. "Distribution patterns for metabolites in medicinal parts of wild and cultivated licorice." Journal of pharmaceutical and biomedical analysis 161 (2018): 464-473.https://doi.org/10.1016/j.jpba.2018.09.004 7. [IF=7.46] Wen Jie Zhang et al."A ratiometric fluorescent and colorimetric dual-signal sensing platform based on N-doped carbon dots for selective and sensitive detection of copper(II) and pyrophosphate ion."Sensor Actuat B- Chem. 2019 Mar;283:215 8. [IF=5.923] Cuihua Chen et al."Variations in Physiology and Multiple Bioactive Constituents under Salt Stress Provide Insight into the Quality Evaluation of Apocyni Veneti Folium."Int J Mol Sci. 2018 Oct;19(10):3042 9. [IF=5.81] Zhang Xiaoyong et al."Comparative Metabolomics Analysis of Cervicitis in Human Patients and a Phenol Mucilage-Induced Rat Model Using Liquid Chromatography Tandem Mass Spectrometry."Front Pharmacol. 2018 Apr;0:282 10. [IF=4.411] Yujiao Hua et al."Quality Evaluation of Pseudostellariae Radix Based on Simultaneous Determination of Multiple Bioactive Components Combined with Grey Relational Analysis."Molecules. 2017 Jan;22(1):13 11. [IF=2.896] Ya-yun Chen et al."Determination of free amino acids and nucleosides and nucleobases in Annona squamosa L. fruitages from different regions in China by LC-QTRAP-MS/MS."Anal Methods-Uk. 2017 Jun;9(25):3862-3869 12. [IF=4.616] Xiaoyong Zhao et al."Lignin as a MALDI matrix for small molecules:A proof of concept."Analyst. 2021 Oct;: 13. [IF=4.411] Mengxia Tan et al."Quality Evaluation of Ophiopogonis Radix from Two Different Producing Areas."Molecules. 2019 Jan;24(18):3220 14. [IF=1.618] Wang Shengnan et al."Simultaneous Determination of Iridoid Glycosides, Phenylpropanoid Glycosides, Organic Acids Nucleosides and Amino Acids in Scrophulariae Radix Processed by Different Processing Methods by HPLC-QTRAP-MS/MS."J Chromatogr Sci. 2021 Jun; 15. [IF=3.373] Yiyuan Luo et al."Quality evaluation of Tetrastigma hemsleyanum different parts based on quantitative analysis of 42 bioactive constituents combined with multivariate statistical analysis."PHYTOCHEMICAL ANALYSIS. 2022 Apr 05 |
dT - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | thymidine deoxyribonucleosides containing thymine bases. The nucleoside formed by thymine through the β-glycosidic linkage to D-ribose. Thymidine is used for the preparation of anti-AIDS drugs (such as zidofuzidine and statofuzidine) and the synthesis of antiviral drugs. It can also be used as a pharmaceutical intermediate for direct export. At present, there are only a handful of manufacturers producing β-thymidine in China, and only a few companies such as Xincheng and Xinghu Technology produce them, mostly by chemical synthesis. It is mainly used for the preparation of anti-AIDS drugs (such as Zidovudine and Shidafudine). Used as a pharmaceutical intermediate to synthesize antiviral and anti-HIV drugs Used for fusion, selection and cloning of hybrid tumors in HT and HAT cocktail methods |
| Biological activity | Thymidine (Deoxythymidine, 2 '-Deoxythymidine, 5-Methyldeoxyuridine, DThyd, NSC 21548) is a pyrimidine nucleoside composed of pyrimidine base thymine connected to glycopide deoxyribose. As a component of DNA, thymidine pairs with adenine in the DNA double helix. |
Last Update：2024-04-09 21:01:54
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