dU
(2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
CAS: 109389-30-2
Molecular Formula: C39H47N4O8P
dU - Names and Identifiers
| Name | (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite |
| Synonyms | dU Uridine, Phosphoramidite 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2'-deoxy- 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-deoxyuridine (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite |
| CAS | 109389-30-2 |
dU - Physico-chemical Properties
| Molecular Formula | C39H47N4O8P |
| Molar Mass | 730.786 |
| Storage Condition | 2-8℃ |
dU - Synthesis and application of a novel phosphoramidite monomer with RNA 3 'terminal suspension structure
Author:
Sun Yongmei , Wei Chao , true
Abstract:
RNA interference (RNAi) is a phenomenon of gene silencing caused by double-stranded RNA, in which small interfering RNA(siRNA) is one of the factors necessary for RNAi to exert its effect. Because the use of RNAi technology can specifically knock out or turn off the expression of specific genes, siRNA has become a potential drug. siRNA has a characteristic structure: 5 'phosphate and 3' hydroxyl, and has a symmetrical 2NT 3 'end suspension. The 3' Terminal overhang plays an important role in the recognition of Dicer and Ago2, the important proteins in RNA interference pathway. We designed and synthesized a novel phosphoramidite monomer with a single-stranded RNA 3 'terminal suspension structure, which maintained the RNA interference activity of siRNA as a 3' terminal suspension, at the same time, single-stranded suspensions can be used for subsequent chemical modification and detection.
Key words:
3' end suspension phosphoramidite monomer, modified
meeting name:
Chinese Chemical Society 29th Academic Annual Meeting Abstract collection -22th: Chemical biology
Meeting Time:
2014
Last Update：2024-01-02 23:10:35
dU - Study on synthesis of amino-modified phosphoramidite monomer
from VIP
Author:
Abstract:
The amino-modified phosphoramidite monomer was synthesized by using readily available 6-amino-1-hexanol, phosphorus reagent and 4-methoxytriphenylchloromethane as raw materials. Through the study of the key factors affecting the yield, the best reaction conditions were found: the ratio of materials (hydroxyl intermediate: phosphorus reagent) was 1:1.5, reaction at 25 ℃ for 3H, the yield was 86.9%. The synthetic process has the advantages of convenient operation, high yield and little pollution, and has broad market application prospect.
Key words:
6-amino-1-hexanol phosphorus reagent 4-methoxytriphenylchloromethane amino-modified phosphoramidite monomer synthesis
DOI:
CNKI:SUN:HXSS.0.2014-10-010
year:
2014
Last Update：2023-08-16 22:05:47
dU - Application of dideoxynucleoside phosphoramidite monomer containing succinamide structure in construction of anti-enzymatic cleavage artificial nucleic acid
from Palm Bridge research
Application (patent) number:
CN202010109483.4
application date:
2020-02-22
Public/Announcement Number:
CN111303227A
Public/announcement date:
2020.06.19
applicant (patent):
China University of Petroleum (East China)
inventor:
Sun Yawei , Sun Li-Mei , Wang Dong , Wang Jigan
National and provincial code:
CN370211
Abstract:
The invention discloses an application of a dideoxynucleoside phosphoramidite monomer containing a succinamide structure in the construction of an artificial nucleic acid resistant to enzymatic cleavage, and belongs to the technical field of non-natural oligonucleotide application. The terminal Group of the artificial nucleic acid is modified with the dideoxynucleoside phosphoramidite monomer containing a succinamide structure, so that the modified artificial nucleic acid has better tolerance to exonuclease; it provides a new choice for the design of nucleic acid probes with good biological stability.
Last Update：2023-08-16 22:05:47
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Product Name: 5'-O-DMT-2'-deoxyuridine-3'-CE Phosphoramidite Request for quotationCAS: 109389-30-2
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Product Name: (2R,3S,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite Request for quotation
CAS: 109389-30-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
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Mobile: 0086 189 4982 3763
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CAS: 109389-30-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
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Wechat: 0086 189 4982 3763
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CAS: 109389-30-2
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CAS: 109389-30-2
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Mobile: 18021002903
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Multiple Specifications
Product Name: 5'-O-DMT-2'-deoxyuridine-3'-CE Phosphoramidite Request for quotationCAS: 109389-30-2
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Email: Lucy@verypharm.com
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