delta4-pregnene-3,20-dione

delta4-pregnene-3,20-dione - Names and Identifiers

Name	Progesterone
Synonyms	Lutex lutren luteol lutidon lutogyl gestone pranone prolidon corporin piaponon luteogan PRIMOLUT progekan luteodyn luteovis luteosan primolut corlutin lutoform Gynlutin fologenon synovex s lutocylol corluvite progestin lipolutin lutocylin luteostab lutromone corlutina gynoluton progestone hormoluton Gynolutone gestormone syntolutan luteinique lutocyclin flavolutan lutocyclinm progesterol pregnendione PROGESTERONE luteohormone glanducorpin Progesterone Glanducorpin hormoflaveine progesteronum lucorteum sol pregnenedione luteal hormone 3,20-pregnene-4 beta-progesterone 4-pregnene-3,20-dione corpus luteum hormone Pregn-4-ene-3,20-dione (S)-Pregn-4-en-3,20-dione delta4-pregnene-3,20-dione PROGESTERONE-WATER SOLUBLE delta(sup4)-pregnene-3,20-dione (6alpha)-6-methyl-3,20-dioxopregn-4-en-17-yl acetate
CAS	57-83-0
EINECS	200-350-6
InChI	InChI=1/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
InChIKey	RJKFOVLPORLFTN-LEKSSAKUSA-N

delta4-pregnene-3,20-dione - Physico-chemical Properties

Molecular Formula	C21H30O2
Molar Mass	314.46
Density	d23 1.166; d20 1.171
Melting Point	128-132 °C (lit.)
Boling Point	394.13°C (rough estimate)
Specific Rotation(α)	186 º (c=1, ethanol)
Flash Point	2℃
Water Solubility	<0.1 g/100 mL at 19 ºC
Solubility	Insoluble in water, soluble in ethanol, ether, chloroform, acetone, dioxane and concentrated sulfuric acid.
Vapor Presure	5.44E-10mmHg at 25°C
Appearance	White powder
Color	Yellow to yellow-brown
Merck	7773
BRN	1915950
Storage Condition	room temp
Stability	Stable. Incompatible with strong oxidizing agents.
Sensitive	Sensitive to light
Refractive Index	182 ° (C=2, Dioxane)
MDL	MFCD00003658
Physical and Chemical Properties	Melting Point: 127 ℃ water-soluble:<0.1g/100 mL (19 ℃) character: white powder solid
Use	Belonging to steroid hormones and progestogens

delta4-pregnene-3,20-dione - Risk and Safety

Risk Codes	R40 - Limited evidence of a carcinogenic effect R45 - May cause cancer R62 - Possible risk of impaired fertility R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable
Safety Description	S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S53 - Avoid exposure - obtain special instructions before use. S16 - Keep away from sources of ignition.
UN IDs	UN 1648 3 / PGII
WGK Germany	3
RTECS	TW0175000
HS Code	29372390
Toxicity	LD50 intraperitoneal in rat: 327mg/kg

delta4-pregnene-3,20-dione - Reference

Reference

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3. Luxin, Guo Qiusheng, Shi Hongzhu, etc. Effects of exogenous methyltestosterone on the growth and gonadal development of natural overwintering Leech.
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5. Wang Shuai, Guo Qiusheng, Shi Hongzhu, etc. Effects of short-term addition of 17 β-e2 on growth and gonadal development of winter Leech.
6. Cai Jie, Yang Yani, Luo Dajuan, Gao Rong, lu fa-ying, Liu Bing-Qian. Detection of progesterone by electrochemical sensor based on triple signal amplification [J]. Analytical Laboratory, 2020,39(09):1019-1023.
7. Yuan, Yongkai, et al. "Fabrication and characterization of lutein-loaded nanoparticles based on zein and phoorolipid: enhancement of water solubility, stability, and bioaccessibility." Journal of agricultural and food chemistry 67.43 (2019): 11977-11985.h
8. Yuan, Yongkai, et al. "Fabrication and characterization of lutein-loaded nanoparticles based on zein and sophorolipid: enhancement of water solubility, stability, and bioaccessibility." Journal of agricultural and food chemistry 67.43 (2019): 11977-11985.h
9. Yuan, Yongkai, et al. "Fabrication and characterization of lutein-loaded nanoparticles based on zein and sophorolipid: enhancement of water solubility, stability, and bioaccessibility." Journal of agricultural and food chemistry 67.43 (2019): 11977-11985.h
10. XU, Yu et al. Nanoparticles based on carboxymethylcellulose-modified rice protein for efficient delivery of lutein. Food & function, 2020, 11.3: 2380-2394.
11. Wang, YH., Li, T., Zhang, RR. et al. Transcript profiling of genes involved in carotenoid biosynthesis among three carrot cultivars with various taproot colors. Protoplasma 257, 949-963 (2020). https://doi.org/10.1007/s00709-020-01482-4
12. [IF=11.161] Wang Jie et al."Embedding similarities between embryos and circulating tumor cells: fundamentals of abortifacients used for cancer metastasis chemoprevention."J Exp Clin Canc Res. 2021 Dec;40(1):1-16
13. [IF=7.514] Lu Qiao et al."Truncated affinity-improved aptamers for 17β-estradiol determination by AuNPs-based colorimetric aptasensor."Food Chem. 2021 Mar;340:128181
14. [IF=7.514] Suo Decheng et al."Trace analysis of progesterone and 21 progestins in milk by ultra-performance liquid chromatography coupled with high-field quadrupole-orbitrap high-resolution mass spectrometry."Food Chem. 2021 Nov;361:130115