demethylzeylasteral
Demethylzeylasteral
CAS: 107316-88-1
Molecular Formula: C29H36O6
demethylzeylasteral - Names and Identifiers
demethylzeylasteral - Physico-chemical Properties
| Molecular Formula | C29H36O6 |
| Molar Mass | 480.59 |
| Density | 1.31 |
| Melting Point | >221°C (dec.) |
| Boling Point | 663.6±55.0 °C(Predicted) |
| Specific Rotation(α) | (c, 1.06 in CHCl3)-67.9 |
| Solubility | DMSO : 250 mg/mL (520.19 mM; Need ultrasonic) |
| Appearance | Yellow crystal |
| Color | Yellow |
| pKa | 4.78±0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| MDL | MFCD16660658 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Tripterygium wilfordii. |
demethylzeylasteral - Reference
| Reference Show more | 1. Wang, Tuanjie, et al. "Comparative analysis of four terpenoids in root and cortex of Tripterygium wilfordii Radix by different drying methods." BMC complementary and alternative medicine 16.1 (2016): 1-11.https://doi.org/10.1186/s12906-016-1453-x 2. [IF=3.659] Wang Tuanjie et al."Comparative analysis of four terpenoids in root and cortex of Tripterygium wilfordii Radix by different drying methods."Bmc Complem Altern M. 2016 Dec;16(1):1-11 |
demethylzeylasteral - Reference Information
| Introduction | norzerylaldehyde: a triterpene monomer from the root bark of Tripterygium wilfordii. Tripterygium wilfordii Hook.f is a woody vine belonging to the genus Tripterygium wilfordii, also known as Huangteng root, xanthophyll, water shikima, gut grass, etc. It is warm in nature, bitter in taste, and has the effects of dispelling wind and removing dampness, relaxing tendons and activating collaterals, detumescence and relieving pain, insecticide and detoxification, etc. |
| preparation | The Medicinal Material of Tripterygium wilfordii Hook. F. Was crushed, weighed and extracted for 2 times by adding 3L of 70% ethanol, extraction time is 20min, the power is 500W, the combined extract, concentrated to extract, add 200ml PH8 sodium bicarbonate solution dissolution, filtration, filtrate add hydrochloric acid to adjust to pH 6.5, add 300ml of ethyl acetate to extract for 2 times, combine the extracts, and evaporate to dryness to obtain crude norzerylaldehyde; Dissolve the crude norzerylaldehyde with methanol, filter through microporous membrane, and prepare high performance liquid phase separation, column: Eighteen alkyl bond and silica gel, mobile phase: acetonitrile-water (40: 60), with differential refractive index detector monitoring to guide product collection, collection liquid is concentrated and dried to product 1.42g, content 98.7%. |
| biological activity | Demethylzeylasteral (T-96) was obtained from triptytum wilfordii Hook F. The active ingredient isolated in, can inhibit UDP-glucuronosyltransferase (UGT) of the subtypes UGT1A6 and UGT2B7, and has immunosuppressive activity. |
| Target | Value |
| UGT1A6 (Cell-free assay) | 0.6 μM(Ki) |
| UGT2B7 (Cell-free assay) | 17.3 μM(Ki) |
| Use | norzerral has strong immunosuppressive, anticancer and anti-inflammatory effects. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: immunosuppressive effect. |
Last Update：2024-04-09 21:21:28
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