distylin
(+-)-taxifolin
CAS: 480-18-2
Molecular Formula: C15H12O7
distylin - Names and Identifiers
| Name | (+-)-taxifolin |
| Synonyms | distylin taxifolin TAXIFOLIN(P) (+-)-taxifolin 2theta-trans)- dihydro-querceti 3,3',4',5,7-pentahydroxy-flavanon 2,3-dihydro-3,3',4',5,7-pentahydroxy-flavon 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4h-1-benzopyran-4-on 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-4h-1-benzopyran-4-on( (2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one (2S,3S)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one |
| CAS | 480-18-2 |
| EINECS | 207-543-4 |
| InChI | InChI=1/C15H12O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,14-19,21H/t14-,15+/m1/s1 |
| InChIKey | CXQWRCVTCMQVQX-LSDHHAIUSA-N |
distylin - Physico-chemical Properties
| Molecular Formula | C15H12O7 |
| Molar Mass | 304.25 |
| Density | 1.3326 (rough estimate) |
| Melting Point | 230-233°C (dec.) |
| Boling Point | 365.09°C (rough estimate) |
| Specific Rotation(α) | (c, 1.03 in 50% Me2CO aq.)+44 |
| Flash Point | 264.1°C |
| Solubility | Easily soluble in ethanol, acetic acid, boiling water, slightly soluble in cold water, almost insoluble in benzene. |
| Vapor Presure | 7.51E-20mmHg at 25°C |
| Appearance | Pale yellow powder |
| Color | White to Yellow |
| BRN | 5299277 |
| pKa | 7.39±0.60(Predicted) |
| Storage Condition | -20°C |
| Refractive Index | 1.4790 (estimate) |
| MDL | MFCD00006845 |
| Physical and Chemical Properties | From the plant of Pinaceae |
distylin - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | LK6920000 |
| HS Code | 29329990 |
| Hazard Class | IRRITANT |
distylin - Reference
| Reference Show more | 1. Gu Yuanyuan Jiang Bo Tian Ming et al. Effects of dihydroquercetin on Hemorheology and other related indexes in rats with focal cerebral ischemia injury [J]. China Pharmacy, 30 vol. 6, pp. 2019-769. 2. Shang Yanqi Yuying Gu Yuanyuan et al. Effects of dihydroquercetin on Hemorheology in rats with myocardial ischemia [J]. Journal of Changchun University of Traditional Chinese Medicine, 2019 035(003):509-512. 3. Gu Yuanyuan Yu Ying Zhou Zhongguang et al. Protective effect of dihydroquercetin on myocardial ischemia model rats and its effect on oxidative stress [J]. Shi Zhen Guomai National Medicine 2019 v.30;No.290(10):72-74. 4. Gu Yuanyuan Jiangbo Liu Xu shangyanqi Liang Hui Zhang Shuxiang Dong Xiaohong Zhou Zhongguang Tianming. Effects of dihydroquercetin on inflammatory factors, oxidative stress and energy metabolism in brain tissue of rats with cerebral ischemia injury [J]. Journal of Liaoning University of Traditional Chinese Medicine, 2019, 21(06):36-38. 5. Song Guanglan, Chen Jun, Xian Wen. Protective effect of taxifolin on hypoxia-reoxygenation-induced injury in H9c2 cardiomyocytes by inhibiting NF-κB signaling pathway [J]. Journal of Clinical and Experimental Medicine, 2020,19(01):54-58. 6. Wu Minjuan, Fei Hongxin Tianming, Zhou Zhongguang, Han Yusheng. Effects of dihydroquercetin on myocardial phosphatidylinositol 3-kinase/glycogen synthase kinase-3β signaling pathway in rats with isoproterenol-induced acute myocardial ischemia [J]. China Medical leads 2020 17(02):15-19. 7. Yang Junjie, Huang Ziyan, Li Lin, et al. Optimization of integrated processing technology for Smilax glabra [J]. Shi Zhen, Chinese medicine, 2018, 29(09):2165-2168. 8. Yang Junjie, Zhang Yanling, Wang Xiaotao, Lu Jiulin. Analysis on the rationality of peeling in the processing of Smilax glabra [J]. Chinese Journal of Experimental prescriptions, 2017,23(03):1-5. 9. Lin Li, Li Huanhuan, Xie Hui, Yan Guojun, Hu Yutao, Lu Jiulin, Mao Chunqin. Quality Evaluation of Inula Inula based on HPLC fingerprint combined with Chemometrics [J]. Chinese herbal medicine, 2021,52(06):1751-1758. 10. Wu, Ya, et al.. "Journal of Food Science 86.1 (2021): 215-227. 11. Lyu, Yunbin, et al. "Identification and characterization of three flavonoid 3-o-glycosyltransfers from Epimedium koreanum Nakai." Biochemical Engineering Journal 163 (2020): 107759.https://doi.org/10.1016/j.bej.2020.107759 12. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 13. [IF=4.939] Jinghui Wang et al."Systems Pharmacology Dissection of Multiscale Mechanisms of Action for Herbal Medicines in Treating Rheumatoid Arthritis."Mol Pharmaceut. 2017;14(9):3201-3217 14. [IF=4.411] Xiaosheng Tang et al."Molecular Structure-Affinity Relationship of Flavonoids in Lotus Leaf (Nelumbo nucifera Gaertn.) on Binding to Human Serum Albumin and Bovine Serum Albumin by Spectroscopic Method."Molecules. 2017 Jul;22(7):1036 15. [IF=3.361] Hui Li et al."Enrichment and purification of polyphenols in pine cone extracts of Pinus koraiensis Sieb. et Zucc. using a novel multi-channel parallel-serial chromatographic system packed with macroporous resin."Rsc Adv. 2015 Mar;5(39):30711-30718 16. [IF=9.038] Yingying Zheng et al."Di-(2-ethyl hexyl) phthalate induces necroptosis in chicken cardiomyocytes by triggering calcium overload."J Hazard Mater. 2020 Apr;387:121696 17. [IF=8.071] Jingzeng Cai et al."Taxifolin ameliorates DEHP-induced cardiomyocyte hypertrophy via attenuating mitochondrial dysfunction and glycometabolism disorder in chicken."Environ Pollut. 2019 Dec;255:113155 18. [IF=6.291] Yuan Zhang et al."Taxifolin alleviates apoptotic injury induced by DEHP exposure through cytochrome P450 homeostasis in chicken cardiomyocytes."Ecotox Environ Safe. 2019 Nov;183:109582 19. [IF=5.81] Mu Jianfei et al."Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects."Fro 20. [IF=4.464] Di Huang et al."A new electrochemical sensor for Taxifolin based on RGO-Co3S4@MoS2 modified electrode."J Electroanal Chem. 2019 Oct;851:113473 21. [IF=3.978] Yunbin Lyu et al."Identification and characterization of three flavonoid 3-O-glycosyltransferases from Epimedium koreanum Nakai."Biochem Eng J. 2020 Nov;163:107759 22. [IF=3.645] Qingyu Zhang et al."Quality control of Semen Hoveniae by high-performance liquid chromatography coupled to Fourier transform-ion cyclotron resonance mass spectrometry."J Sep Sci. 2021 Sep;44(18):3366-3375 23. [IF=3.645] Chen Wang et al."Qualitative and quantitative analysis of phenolic compounds in blueberries and protective effects on hydrogen peroxide-induced cell injury."J Sep Sci. 2021 Jul;44(14):2837-2855 24. [IF=3.167] Ya Wu et al."Anti-obesity effect of Liupao tea extract by modulating lipid metabolism and oxidative stress in high-fat-diet-induced obese mice."J Food Sci. 2021 Jan;86(1):215-227 25. [IF=2.19] Sheng-xiang Yang et al."Extraction of flavonoids from Cyclocarya paliurus (Juglandaceae) leaves using ethanol/salt aqueous two-phase system coupled with ultrasonic."J Food Process Pres. 2020 Jun;44(6):e14469 26. [IF=1.296] Han Meiling et al."Analysis of flavonoids and anthocyanin biosynthesis-related genes expression reveals the mechanism of petal color fading of Malus hupehensis (Rosaceae)."Braz J Bot. 2020 Mar;43(1):81-89 27. [IF=3.935] Junmao Li et al."Comprehensive chemical profiling of the flowers of Citrus aurantium L. var. amara Engl. and uncovering the active ingredients of lipid lowering."J Pharmaceut Biomed. 2022 Mar;211:114621 28. [IF=6.576] Junkun Pan et al."Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure-Activity Relationship, Kinetics and Interaction Mechanism."Frontiers in Nutrition. 2022; 9: 892426 |
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