Molecular Formula | C20H26O6 |
Molar Mass | 362.419 |
Density | 1.37±0.1 g/cm3(Predicted) |
Melting Point | 274-276℃ (Decomposition) (ethanol ) |
Boling Point | 610.3±55.0 °C(Predicted) |
Appearance | Cryst. |
pKa | 12.66±0.60(Predicted) |
Storage Condition | 2-8℃ |
Physical and Chemical Properties | White needle-like color crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Xihuangcao. |
biological activity | Enmein was isolated from I. serra and had an immunosuppressive effect. |
Cell Line: | Splenic lymphocyte cells Splenic lymphocyte cells |
Concentration: | 3.13, 6.25, 12.5, 25 μg/ml 5.5 μg/ml, 11 μg/ml, 22 μg/ml |
Incubation Time: | 48 hours 48 hours |
Result: | Exhibited an IC 50 value of 17 μg/ml in splenic lymphocytes. Caused S stage cells and G2/M stage cells decreased. Had inhibitory effect on IL-2 release in blood. |
Animal Model: | Balb/c mice |
Dosage: | 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg |
Administration: | Injected to ear; 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg; 5 days |