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entrecitinib

Entrectinib

CAS: 1108743-60-7

Molecular Formula: C31H34F2N6O2

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entrecitinib - Names and Identifiers

Name Entrectinib
Synonyms RXDX-101
Entrectinib
entrecitinib
NVP-LGK974, WNT974
Entrectinib(NMS-E628)
N-(5-(3,5-difluorobenzyl)-1H-indazol-3-yl)-4-(4-methylpiperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide
N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide
CAS 1108743-60-7

entrecitinib - Physico-chemical Properties

Molecular FormulaC31H34F2N6O2
Molar Mass560.6375
Density1.340±0.06 g/cm3(Predicted)
Boling Point717.5±60.0 °C(Predicted)
Solubility DMSO: ≥ 31 mg/mL
pKa12.01±0.43(Predicted)
Storage Condition-20℃

entrecitinib - Upstream Downstream Industry

Raw MaterialsBenzamide, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)(2,2,2-trifluoroacetyl)amino]-
Intermediate
3,5-Difluorobenzyl bromide
5-(3,5-difluorobenzyl)-2-fluorobenzonitrile
4-Fluoro-2-nitrobenzoic acid
tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate
4-Fluoro-2-Nitro-Benzoic Acid Tert-Butyl Ester
tert-butyl 2-amino-4-(4-methylpiperazin-1-yl)benzoate
5-(3,5-difluorobenzyl)-1H-indazol-3-amine
4-(4-methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)(2,2,2-trifluoroacetyl)amino]benzoic acid tert-butyl ester
4-(4-methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)amino]benzoic acid tert-butyl ester
4-(4-methylpiperazin-1-yl)-2-[(tetrahydropyran-4-yl)(2,2,2-trifluoroacetyl)amino]benzoic acid trifluoroacetate
3-Cyano-4-fluorobenzeneboronic acid
Tetrahydro-4H-pyran-4-one

entrecitinib - Preparation solution concentration reference

 1mg5mg10mg
1 mM1.784 ml8.918 ml17.837 ml
5 mM0.357 ml1.784 ml3.567 ml
10 mM0.178 ml0.892 ml1.784 ml
5 mM0.036 ml0.178 ml0.357 ml
Last Update：2024-01-02 23:10:35
entrecitinib
Supplier List
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Entrectinib Visit Supplier Webpage Request for quotation
CAS: 1108743-60-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Entrectinib Visit Supplier Webpage Request for quotation
CAS: 1108743-60-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Entrectinib Visit Supplier Webpage Request for quotation
CAS: 1108743-60-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Entrectinib Visit Supplier Webpage Request for quotation
CAS: 1108743-60-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
View History
entrecitinib
Raw Materials for entrecitinib
Benzamide, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)(2,2,2-trifluoroacetyl)amino]-
Intermediate
5-(3,5-difluorobenzyl)-2-fluorobenzonitrile
tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate
4-Fluoro-2-Nitro-Benzoic Acid Tert-Butyl Ester
3-Cyano-4-fluorobenzeneboronic acid
Tetrahydro-4H-pyran-4-one
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