ethanoicacid,dichloro-,methylester
Methyl dichloroacetate
CAS: 116-54-1
Molecular Formula: C3H4Cl2O2
ethanoicacid,dichloro-,methylester - Names and Identifiers
ethanoicacid,dichloro-,methylester - Physico-chemical Properties
| Molecular Formula | C3H4Cl2O2 |
| Molar Mass | 142.97 |
| Density | 1.381 g/mL at 25 °C (lit.) |
| Melting Point | -52 °C (lit.) |
| Boling Point | 143 °C (lit.) |
| Flash Point | 176°F |
| Water Solubility | Slightly soluble |
| Solubility | 4g/l |
| Vapor Presure | 5.5mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless |
| BRN | 1747542 |
| PH | 3.8 (4g/l, H2O, 20℃) |
| Storage Condition | room temp |
| Refractive Index | n20/D 1.442(lit.) |
| Physical and Chemical Properties | Character: colorless transparent liquid. Irritating. melting point -51.9 ℃ boiling point 142.8 ℃ relative density 1.3774 refractive index 1.4421 flash point 80 ℃ solubility insoluble in water, soluble in ethanol. |
| Use | Used as raw materials and dye intermediates in the pharmaceutical industry |
ethanoicacid,dichloro-,methylester - Risk and Safety
| Risk Codes | R20 - Harmful by inhalation R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect R38 - Irritating to the skin R11 - Highly Flammable |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S16 - Keep away from sources of ignition. S24 - Avoid contact with skin. S9 - Keep container in a well-ventilated place. |
| UN IDs | UN 2299 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | AG6625000 |
| TSCA | Yes |
| HS Code | 29154000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
ethanoicacid,dichloro-,methylester - Upstream Downstream Industry
| Raw Materials | Methyl alcohol Chloroacetic acid |
| Downstream Products | chloroamphenicol thiamphenicol |
ethanoicacid,dichloro-,methylester - Nature
Open Data Verified Data
colorless transparent liquid. Flammable, toxic, irritant. The relative density was 1. 3774. Melting Point -51.9 °c. Boiling point 142.8 °c. Flash point 80 °c. Refractive index 4421. Insoluble in water, soluble in ethanol.
Last Update：2024-01-02 23:10:35
ethanoicacid,dichloro-,methylester - Preparation Method
Open Data Verified Data
dichloroacetic acid and methanol are esterified to form dichloroacetic acid methyl ester, and the crude ester is neutralized, washed with water, distilled, and distilled to a finished product.
Last Update：2022-01-01 10:33:21
ethanoicacid,dichloro-,methylester - Use
Open Data Verified Data
pharmaceutical synthesis of intermediates for the manufacture of chlortetracycline, chloramphenicol and other drugs.
Last Update：2022-01-01 10:33:21
ethanoicacid,dichloro-,methylester - Safety
Open Data Verified Data
- toxic. Irritation of the eyes, skin and mucous membranes, water formation of corrosive substances. The equipment should be sealed to prevent leakage and keep good ventilation. The protective equipment of the operator should be complete and correctly used.
- the iron drum is lined with plastic packaging. Hazardous materials shall be stored and transported according to regulations.
Last Update：2022-01-01 10:33:21
ethanoicacid,dichloro-,methylester - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | used as raw material and dye intermediate in Pharmaceutical Industry used as intermediate in organic synthesis intermediate in pharmaceutical synthesis. It is used in the manufacture of drugs such as Monascus and chloramphenicol. It is also used in the dye industry. |
| production method | is obtained by esterification of dichloroacetic acid with methanol. The dichloroacetic acid is put into the reaction pot, heated to 120 ° C., methanol is added dropwise for reaction, the generated Ester and water are continuously distilled out, and the vapor condenser is cooled to a mixture of Ester, water, alcohol and acid, it flows into the water separator, and flows into the crude methyl dichloroacetate storage tank through the liquid sealing pipe from the lower part. The alcohol and water return to the reaction pot through the overflow of the water separator to continue the reaction. Crude dichloroacetic acid methyl ester was neutralized to slight alkalinity with 10% sodium carbonate solution at room temperature, allowed to stand and separated, and then the ester layer was washed with water. The crude ester is distilled under reduced pressure to separate low boiling substances such as water and methanol, and the fraction above 65 ℃(8.0kPa) is collected as the finished product. Each ton of product consumption of dichloroacetic acid (≥ 90%)1100kg, methanol 360kg. |
| category | toxic substances |
| toxicity grade | high toxicity |
| Acute toxicity | inhalation-rat LCL0: 2000 PPM/30 min |
| flammability hazard characteristics | ; toxic smoke emitted by water vapor|
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Separate from food and oxidant |
| fire extinguishing agent | foam, dry powder, carbon dioxide, sand |
Last Update：2024-04-10 22:29:15
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Product Name: Methyl dichloroacetate Request for quotationCAS: 116-54-1
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Methyl dichloroacetate Request for quotationCAS: 116-54-1
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Spot supply
Product Name: Methyl dichloroacetate Request for quotationCAS: 116-54-1
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
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Raw Materials for ethanoicacid,dichloro-,methylester
Downstream Products for ethanoicacid,dichloro-,methylester