fmoc-D-homophenylalanine

fmoc-D-homophenylalanine - Names and Identifiers

Name	N-fmoc-D-homophenylalanine
Synonyms	Fmoc-D-Hfe-OH FMOC-D-HPH-OH FMOC-D-HFE-OH FMOC-D-HPHE-OH Fmoc-D-Homophe FMOC-D-HOMOPHE FMOC-D-HOPHE-OH Fmoc-D-HoPhe-OH Fmoc-D-Homophe-OH FMOC-D-HOMOPHENYL-ALA fmoc-D-homophenylalanine FMOC-HOMO-D-PHENYLALANINE N-fmoc-D-homophenylalanine FMOC-(R)-2-AMINO-4-PHENYLBUTYRIC ACID Benzenebutanoic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-,(αR)-
CAS	135994-09-1 135944-09-1

fmoc-D-homophenylalanine - Physico-chemical Properties

Molecular Formula	C8H6ClN6O3P
Molar Mass	300.6
Density	2.27±0.1 g/cm3(Predicted)
Boling Point	628.3℃ at 760mmHg
pKa	-0.62±0.10(Predicted)
Storage Condition	2-8°C
MDL	MFCD00151917

fmoc-D-homophenylalanine - Risk and Safety

WGK Germany

fmoc-D-homophenylalanine - Introduction

N-fluorenylmethoxycarbonyl-D-homophenylalanine is an organic compound, also known as N-Fmoc-D-phenylalanine. The following is an introduction to its nature, use, preparation and safety information:

Nature:
N-fluorenylmethoxycarbonyl-D-homophenylalanine is a white or off-white crystalline powder with a special aromatic odor. It is stable at room temperature, insoluble in water, soluble in some organic solvents such as dichloromethane, acetone and alcohols.

Use:
N-fluorenylmethoxycarbonyl-D-homophenylalanine is mainly used for the synthesis of peptides and proteins by solid phase synthesis. As a protecting group, it can protect the active functional groups in amino acids, so that other parts can be chemically reacted. In solid phase synthesis, N-fluorenylmethoxycarbonyl-D-homophenylalanine can be used for polypeptide chain extension and synthesis.

Preparation Method:
The synthesis of N-fluorenylmethoxycarbonyl-D-homophenylalanine is generally obtained by carboxylic acid protection of D-homophenylalanine (taking Fmoc protecting group as an example). A common synthetic method is the condensation of D-homophenylalanine with N-fluorenone, followed by further reaction to give N-fluorenylmethoxycarbonyl-D-homophenylalanine.

Safety Information:
N-fluorenylmethoxycarbonyl-D-homophenylalanine generally does not have greater toxicity and irritation. However, as with any chemical, use should follow safe practices and avoid contact with skin, eyes and mucous membranes. When using, pay attention to protective measures, such as wearing protective gloves and glasses, and ensure that the operation in a well-ventilated area. In case of misuse or contact discomfort, seek medical attention immediately.

Last Update：2024-04-09 20:45:29