gamma-Schisandrin
Schizandrin B
CAS: 61281-37-6
Molecular Formula: C23H28O6
gamma-Schisandrin - Names and Identifiers
gamma-Schisandrin - Physico-chemical Properties
| Molecular Formula | C23H28O6 |
| Molar Mass | 400.47 |
| Density | 1.148±0.06 g/cm3(Predicted) |
| Melting Point | 120-121°C |
| Boling Point | 545.0±50.0 °C(Predicted) |
| Flash Point | 220.4°C |
| Solubility | Easily soluble in benzene and chloroform, insoluble in water. |
| Vapor Presure | 2.22E-11mmHg at 25°C |
| Appearance | Colorless crystal |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.543 |
| MDL | MFCD00210555 |
| Physical and Chemical Properties | Soluble in petroleum ether, methanol, ethanol, soluble in ether, soluble in benzene and chloroform, insoluble in water. Derived from Schisandra chinensis (Turcz.)Baill. |
gamma-Schisandrin - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29329990 |
gamma-Schisandrin - Reference
| Reference Show more | 1. Cheng Zhenyu, Song Haiyan, Yang Yingjie et al. Study on static purification of lignans from schisandra chinensis by AB-8 macroporous adsorption resin [J]. Northern horticulture 2015 000(007):141-145. 2. Wu Hao, Shan-Zhang, lunar November, Yu Xiaojing et al. Simultaneous determination of five lignans in schisandra chinensis from different habitats by HPLC [J]. Chinese national and folk medicine 2018 v.27;No.322(05):13-17. 3. Teng Chunxiao, Jin, Honghua, Hong Lan. Effect of schisandrin B on the expression of AkT, mTOR and TGF-β1 in myocardial fibrosis induced by angⅱ [J]. Chinese patent medicine 2019 41(06):1423-1426. 4. Jiang Enping Tang Ze Li Yu Chun Yan Yu Chun Rong Zhu Wei. Protective effect of schisandrin B on cerebral ischemia-reperfusion injury in rats and its mechanism [J]. Journal of Jilin University (Medicine edition) 2016 42(05):860-865 1045. 5. Yang qingsuixin, Wang Baosen et al. Protective effect of schisandrin B on SH-SY5Y cell injury induced by glutamate and its mechanism [J]. Journal of Jilin University (Medical Sciences) 2016 42(1):80-84. 6. Song, Feng, Yuan, Shi, Jian, Yi, et al. Preparation of schisandrin B polymer micelles and determination of entrapment efficiency [J]. Shi Zhen Guomai National Medicine 2018 029(011):2659-2661. 7. Zhao Dawei, Wang Haobo, Li Jiali, etc. Optimization of microwave-assisted extraction of lignans from schisandra chinensis by Box-Benhnken response surface methodology [J]. Jilin agriculture 2019 447(06):52-54. 8. Zhang Yueyi, Zhao Yan, Liu Yonghui et al. Optimization of ultrasonic extraction of lignans from schisandra chinensis seeds [J]. Journal of Northwest Sci-Tech University of Agriculture and Forestry: natural science edition 2015(06):215-220. 9. Dai Hui, Suhang, Cai Pengfei, et al. Changes of color and eight lignans of schisandra vinegar before and after steaming [J]. Chinese patent medicine 2019 41(05):1091-1096. 10. Zhang Yueyi Liu Yong Hui Zhao Yan warm Cheng Ming Sheng Yanling Yang He Liu Shuangli Zhang Lianxue. Optimization of ultrasonic-assisted ethanol extraction of lignans from schisandra chinensis by response surface methodology [J]. Journal of Food Safety and quality testing 2014 5(06):1855-1861. 11. Soviet Union Lin, Li Min, Xu Min, etc. Predictive analysis of quality markers of schisandra chinensis before and after processing with vinegar based on multivariate statistical analysis and network pharmacology [J]. Chinese Herbal Medicine, 2015, Volume 50, Issue 19, pages 4643-4653, ISTIC PKU CSCD CA, 2019. 12. Ma, Hui, Yu, liantin, Yang, Li, Heng, et al. Purification and antioxidant activity of lignans from schisandra chinensis [J]. Chinese Journal of Traditional Chinese Medicine 2019(12). 13. Wang Guoli wishes Hong, Yan, Lin, Hai, et al. Simultaneous determination of six lignans in schisandra chinensis by Reversed-phase high performance liquid chromatography [J]. Journal of Food Safety and quality testing 2014 000(008):2470-2475. 14. Liying Yang, Weiying Guo. Simultaneous determination of five components in Yixin ningshen tablets by HPLC-ELSD method [J]. Chinese herbal medicine 2015 38(012):2619-2622. 15. Ma, Hui, Feng, Bo, Zhu, Heyun, et al. Antioxidant and anti-inflammatory activities of total lignans from schisandra chinensis [J]. Food Research and development 2019(11). 16. Wei Yajie, Zhang Zekun, Guan Yanling, etc. Hugan Pian HPLC fingerprint and multi-component quantitative analysis [J]. Central South Pharmaceutical Journal, 2018, 016(001):31-34. 17. Cen Renjun, Zhang Wenzhen, Wei Xueliang. Effects of schisandrin B on myocardial oxidative stress indexes and inflammatory factors in exhaustive exercise rats [J]. Northwest Agricultural Journal, 2020,29(09):1310-1316. 18. Jin Miao, Liu Jinna, Liu Hui, Black Yu Rong, Liu Yulan. Effects of different processing methods on lignans of introduced schisandra chinensis in Shaanxi [J]. Shaanxi Agricultural Sciences, 2020,66(11):17-20. 19. Jiao Meiyu, Yu-yue, Wu Haoxian, Kang Tingguo, Zhang Hui. Study on the mechanism and qualitative recognition model of "color discrimination and qualitative analysis" of schisandra chinensis [J]. China Pharmacy, 2020,31(24):3007-3012. 20. Zhang, Qi, et al. "Development of a matrix solid-phase dispersion extraction combined with high-performance liquid chromatography for determination of five lignans from the Schisandra chinensis." Journal of Chromatography B 1011 (2016): 151-157.https://doi 21. [IF=6.079] Hongyan Zhu et al."Sedative and hypnotic effects of supercritical carbon dioxide fluid extraction from Schisandra chinensis in mice."J Food Drug Anal. 2016 Oct;24:831 22. [IF=4.759] Huifen Ma et al."The in-capillary- 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)-sweeping micellar electrokinetic chromatography - Diode array detector method for screening and quantifying trace natural antioxidants from Schisandra chinensis."J Ch 23. [IF=3.935] Yunlong Guo et al."Rapid characterization of Schisandra species by using direct analysis in real time mass spectrometry."J Pharmaceut Biomed. 2021 Jan;192:113648 24. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 25. [IF=4.411] Zhiman Li et al.Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis.Molecules. 2021 Jan;26(22):6882 26. [IF=4.36] Zhenghua Wu et al."Schisandrol A the main active ingredient of Schisandrae Chinensis Fructus, inhibits pulmonary fibrosis through suppression of the TGF-β signaling pathway as revealed by UPLC-Q-TOF/MS, network pharmacology and experimental verification. |
gamma-Schisandrin - Reference Information
| Plant Source: | schisandra chinensis |
| schisandra chinensis Extract | schisandrin B is an active substance extracted from schisandra chinensis. The latest research shows that schisandra contains a variety of free radical scavenging active ingredients. Researchers from the Hong Kong traditional Chinese medicine research center and the Hong Kong University of Science and Technology isolated some effective components from schisandra chinensis, mainly lignans, such as schisandrin a, B, c, schisandrin, etc. Studies have proved that the active ingredients of schisandra chinensis can effectively eliminate oxygen free radicals, stimulate the body to produce self-antioxidant substances, and remove a large number of free radicals in time. After in-depth research, the researchers found that: schisandrin schisandra main anti-free radical active ingredients for schisandrin A, schisandrin B, and schisandrin B the strongest anti-free radical effect. |
| schisandrin B | the commonly used traditional Chinese medicine Schisandra chinensis (Turcz.) baill. The dry mature fruit, mainly contains lignans, volatile oils, polysaccharides and other components. There are about 25 species of schisandra in the world, mainly distributed in East Asia and a few in southeast America. China is the center of the distribution of this genus, there are 18 species of Schisandra plants in China, including about 13 species of medicinal, Chinese Pharmacopoeia Schisandra chinensis Schisandra chinensis (Turcz.) baill. Or Schisandra sphenanthera Rehd. etWils. In the early 60 s, Kochetkov and others isolated schisandrin, deoxyschisandrin, γ-schisandrin, schisandrin and pseudo-γ-schisandrin from schisandrin, the structures of the latter two were not identified. In order to clarify the effective components of schisandra chinensis, under the guidance of clinical and pharmacological experiments, in 1972, the Institute of Chinese herbal medicine established that the ethanol extract of schisandra chinensis seeds can significantly reduce the high serum alanine aminotransferase in mice caused by carbon tetrachloride and other chemical substances and inhibit the central nervous system. The deoxyschisandrin, schisandrin, schisandrin B, schisandrin C, schisandrin B, schisandrin B, schisandrin B, schisandrin B, schisandrin B were separated from the ethanol extract by silica gel column chromatography and thin layer chromatography, schisandra chinensis Ester A and schisandra chinensis Ester B seven lower transaminase activity of biphenyl Cyclooctene lignans. In order to confirm the three-dimensional structure of schisandrin B, schisandrin methyl as raw material, after hydrolysis, oxidation of chromic anhydride, hydrazone was made from hydrazine hydrate, the latter was catalyzed by potassium tert-butoxide after catalytic hydrogenation, S-schisandrin B was mentioned. some components of schisandra chinensis can significantly inhibit the covalent binding between CCl4 and microsomal lipids, partially protect the integrity of endoplasmic reticulum membrane structure and function, and thus alleviate the damage of hepatocytes. Schisandrin B, C and alcohol B have obvious inducing effect on animal liver microsomal cytochrome P-450. Schisandra chinensis crude polysaccharide can significantly decrease the increased SGPT in mice with liver injury, and protect the liver cell membrane through antioxidant effect. It can significantly increase the content of liver glycogen in mice with carbon tetrachloride liver injury, improve the energy storage of the body, and help to resist the damage of foreign harmful substances to the liver. Schisandra chinensis emulsion can increase the content of cAMP in plasma and liver tissue of mice, and its protective effect may be related to the increase of cAMP in liver tissue. |
| Chemical Structure | the core structure of schisandrin is biphenyl Cyclooctene lignans, schisandrin B is the biphenyl Cyclooctene lignans with the highest content in schisandra chinensis. |
| mechanism of action of schisandrin B against free radicals | schisandrin B is a potent anti-free radical activator. On the one hand, it constantly "removes" excess free radicals; On the other hand, it activates the body's anti-free radical defense system, promotes the balance of the body, and protects the cell membrane from the invasion of free radicals, reduce the body by free radicals Aggression and the risk of disease, anti-aging. Schisandrin B is easy to lose electrons after meeting with free radicals and is converted into neutral substances that are harmless to the human body, thus interrupting the chain oxidation reaction of free radicals. Schisandrin B has the strongest scavenging effect on oxygen free radicals and hydroxyl free radicals. Studies have shown that schisandrin B has a greater scavenging effect on endogenous oxygen free radicals than vitamin E; at the same time, schisandrin B can activate endogenous glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) activity to achieve the role of "scavenging" free radicals. This major discovery has rewritten the current situation that the basic research on the anti-free radical of traditional Chinese medicine is relatively weak, and is called "one of the four inventions of Chinese Medicine Science in Hong Kong. |
| Use | for content determination/identification/pharmacological experiments. Pharmacological Efficacy: schisandra chinensis active ingredients can effectively eliminate oxygen free radicals, while stimulating the body to produce their own antioxidant substances, timely removal of a large number of free radicals. |
Last Update：2024-04-09 15:16:51
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Product Name: Schizandrin B Request for quotation
CAS: 61281-37-6
Tel: 17505222756
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Mobile: +86-17551318830
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CAS: 61281-37-6
Tel: 17505222756
Email: pules.cn@gmail.com
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Product Name: Schizandrin B Visit Supplier Webpage Request for quotationCAS: 61281-37-6
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