Molecular Formula | C15H16O5 |
Molar Mass | 276.28 |
Density | 1.336±0.06 g/cm3(Predicted) |
Melting Point | 197.0-197.5 °C |
Boling Point | 464.7±45.0 °C(Predicted) |
Solubility | Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Appearance | Powder |
pKa | 6.77±0.70(Predicted) |
Storage Condition | 2-8°C |
In vivo study | Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency. |
biological activity | Hamaudol is a chromone isolated from Saposhnikovia divaricata. The activity of cyclooxygenase (COX)-1 and COX-2 was significantly inhibited by Hamaudol, with IC50 values of 0.30 and 0.57 mM, respectively, and had effective analgesic and anti-inflammatory effects. |