hexoniumdibromide

Name	Hexamethonium bromide
Synonyms	hexameton gangliostat Methobromine simpatoblock hexoniumdibromide Hexamethonium bromide hexamethioniumbromide Hexamethonium bromide hydrate hexamethylenebis(trimethyl-ammoniudibromide Hexamethylenebis(trimethylammonium bromide) hydrate N,N,N,N',N',N'-hexamethylhexane-1,6-diaminium dibromide N,N,N,N',N',N'-Hexamethylhexane-1,6-diammonium dibromide Hexamethonium bromide,Hexane-1,6-bis(trimethylammonium bromide), N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dibromide
CAS	55-97-0
EINECS	200-249-7
InChI	InChI=1/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
InChIKey	FAPSXSAPXXJTOU-UHFFFAOYSA-L

Molecular Formula	C12H30Br2N2
Molar Mass	362.19
Melting Point	~285°C (dec.)
Solubility	Water (Slightly)
Appearance	Crystalline Powder and Agglomerates
Color	White
Merck	14,4688
BRN	3715749
PH	pH (20g/l, 25℃) : 4.5～6.5
Storage Condition	Inert atmosphere,Room Temperature
MDL	MFCD00011787
Use	This product is for scientific research only and shall not be used for other purposes.
In vitro study	Hexamethonium Bromide was effective against Ach and Carbachol (CCh) responses to the amplitude of the rat scaphohyoid muscle endplate, with EC50 of 300 μm and 100 μm, respectively. The amplitude of neuro-evoked endplate currents (e.p.cs) was increased by Hexamethonium Bromide (50-200 μm) in the presence of 0.6 μm tubocurarine. In rat muscle homogenates, Hexamethonium Bromide was also a weak inhibitor of acetylcholinesterase activity with an EC50 of 1.5 mM. In rat diaphragmatic muscle on one side, Hexamethonium Bromide (200 μm) decreased endplate currents (e.p.cs) (reduced by ~ 25%) and micro-endplate current (m.e.p.cs) (reduced by ~ 20%) decay time constant. Under low-frequency stimulation (0.5-2Hz), Hexamethonium Bromide (200 μm) increases the quantum content of e.p.c. By 30-40%.

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	2
RTECS	BQ8575000
TSCA	Yes
HS Code	29239000

EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
Biological activity	HexamethoniumDibromide is a selective neuronal nicotinic AChR selective antagonist in the nerve center.
Target	Value
Animal Model:	Male normotensive Wistar rats (280-320 g), SHRs
Dosage:	0.2 mg/kg, 1.0 mg/kg, 5.0 mg/kg, 25 mg/kg
Administration:	Intravenous injection
Result:	Significantly reduced the RSNA, MAP and HR in the Wistar rats and the SHRs.

Last Update：2024-04-10 22:29:15

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hexoniumdibromide

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