hypaque60
meglumine diatrizoate
CAS: 131-49-7
Molecular Formula: C18H26I3N3O9
hypaque60 - Names and Identifiers
| Name | meglumine diatrizoate |
| Synonyms | d- hypaque60 hypaque13.4 gastrografin cardiografin MeglumineDiatrizoate Diatrizoate Meglumine meglumine diatrizoate diatrizoatemethylglucamine d-glucitol,1-deoxy-1-(methylamino)-,3,5-bis(acetylamino)-2,4,6-triiodobenzo glucitol,1-deoxy-1-(methylamino)-,3,5-diacetamido-2,4,6-triiodobenzoate(salt |
| CAS | 131-49-7 |
| EINECS | 205-024-7 |
| InChI | InChI=1/C11H9I3N2O4.C7H17NO5/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-2H3,(H,15,17)(H,16,18)(H,19,20);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1 |
hypaque60 - Physico-chemical Properties
| Molecular Formula | C18H26I3N3O9 |
| Molar Mass | 809.13 |
| Density | 1.9465 (estimate) |
| Melting Point | 189-193° (dec) |
| Boling Point | 614.1°C at 760 mmHg |
| Flash Point | 325.2°C |
| Solubility | DMSO (Slightly), Water (Slightly) |
| Vapor Presure | 6.19E-16mmHg at 25°C |
| Appearance | White powder |
| Color | Rhombic needles |
| Odor | sltly sweet taste |
| Storage Condition | Refrigerator |
| MDL | MFCD00069632 |
hypaque60 - Risk and Safety
| WGK Germany | 3 |
| RTECS | LZ4315000 |
| Toxicity | TDLo scu-man: 214 mg/kg 34ZIAG -,392,69 |
hypaque60 - Compound Meglumine Diatrizoate Injection
Authoritative Data Verified Data
This product is a sterilized aqueous solution made of sodium diatrizoate 1 part and meglumine diatrizoate 6. 6 parts plus appropriate amount of sodium hydroxide. The total amount of sodium diatrizoate (C13H9I3N2NaO4) and meglumine diatrizoate (C13H9I3N2NaO4 • C7H17NO5) shall be 90.0%-110.0% of the labeled amount
trait
This product is colorless to light yellow clear liquid.
identification
- take about 1ml of this product, steam dry, small heat, that is to produce purple iodine vapor.
- take 0.1 of this product, add 1ml of ferric chloride test solution and 2ml of 20% sodium hydroxide solution to generate brown-red precipitate, which is then dissolved into brown-red solution.
- take an appropriate amount of this product and dilute it with water to make a solution containing 2mg of total amount of diatrizoate sodium and meglumine diatrizoate per 1 ml; Take 20mg of the reference product of diatrizoate acid and Add 10ml of 0.04% sodium hydroxide solution to dissolve. According to the thin layer chromatography (General 0502) test, absorb the above two solutions of 10 u1, respectively, on the same silica gel HF254 thin layer plate, with n-butanol-glacial acetic acid-water (4:1:5) for the development of the agent, expand, dry, set the UV light (254nm) under the inspection. The position of the main spot displayed by the test solution should be the same as that of the control solution.
examination
- the pH value should be 6.0 to 7.6 (General 0631).
- the color of this product, compared with the yellow 6 Standard Colorimetric liquid (General Principles 0901 The first method), not deeper.
- free iodine take an appropriate amount of this product (about equivalent to the total amount of diatrizoate Meglumine and diatrizoate sodium l. lg of potassium iodide and 10ml of water were added. After shaking and dissolving, several drops of starch indicator solution were added and shaken well.
- iodide take the right amount of this product (about equivalent to the total amount of diatrizoate Meglumine and diatrizoate sodium l. Log), dilute to 10ml with water, Dropwise add dilute nitric acid to precipitate completely, then add excess dilute nitric acid 3ml, stir, filter, precipitate washed with 5ml water, combine filtrate and wash, add 1ml of concentrated hydrogen peroxide solution and 1ml of chloroform, shake, and let stand. After stratification, the chloroform layer, such as color, and 0.0013% potassium iodide solution (1 of 10mg per lml) 4.0ml of the control solution prepared by the same method should not be deeper.
- pyrogen to take this product, according to the law (General rule 1142), the dose of rabbit body weight per lkg slow injection of 3ml, should comply with the provisions.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take an appropriate amount of this product for precision measurement (about 5g of total amount of meglumine diatrizoate and diatrizoate sodium), put it in a 100ml measuring flask, dilute it with water to the scale, shake well, take 10ml for precision measurement, add 30ml of sodium hydroxide solution and l of zinc powder. Og, refluxing for 30 minutes, cooling, condenser tube with a small amount of water washing, filtering, flask and filter water washing 3 times, each 15ml, combined wash and filtrate, add 5ml of glacial acetic acid and 5 drops of eosin sodium indicator solution, and use silver nitrate titration solution (0.lmol/L) titration. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to a total of 26.04mg of meglumine diatrizoate and sodium diatrizoate.
category
diagnostic medication.
specification
Based on the total amount of meglumine diatrizoate and sodium diatrizoate (l): 0.3g(2 )20ml:12g (3 )20ml:15.2g
storage
light shielding, closed storage.
Last Update：2022-01-01 13:43:24
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Spot supply
Product Name: Meglumine Diatrizoate Visit Supplier Webpage Request for quotationCAS: 131-49-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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