indoline-6-carboxamide

indoline-6-carboxamide - Names and Identifiers

Name	indoline-6-carboxamide
Synonyms	Indoline-6-carboxamide indoline-6-carboxamide 2,3-Dihydro-1H-indole-6-carboxamide 1H-Indole-6-carboxamide, 2,3-dihydro- 1H-Indole-6-carboxaMide, 2,3-dihydro-
CAS	1158761-65-9
InChI	InChI=1S/C9H10N2O/c10-9(12)7-2-1-6-3-4-11-8(6)5-7/h1-2,5,11H,3-4H2,(H2,10,12)

indoline-6-carboxamide - Physico-chemical Properties

Molecular Formula	C9H10N2O
Molar Mass	162.19
Density	1.217±0.06 g/cm3(Predicted)
Boling Point	321.3±31.0 °C(Predicted)
pKa	16.55±0.20(Predicted)
Storage Condition	Room Temprature

indoline-6-carboxamide - Introduction

2,3-Dihydro-1H-indole-6-carboxamide is an organic compound with the chemical formula C9H9N3O and a single amine group and formyl group. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: 2,3-Dihydro-1H-indole-6-carboxamide is generally a colorless to slightly yellow crystalline solid.
-Solubility: It has poor solubility in water, but it can be dissolved in organic solvents, such as ethanol and dimethylformamide.
-Melting point: Its melting point is 172-174°C.
-Chemical properties: 2,3-dihydro-1H-indole-6-carboxamide is an amide compound, which can undergo typical amide reactions, such as hydrolysis and esterification.

Use:
-Drug intermediate: 2,3-dihydro-1H-indole-6-carboxamide is an important intermediate for the synthesis of many drugs, such as anti-cancer drugs and antiviral drugs.
-Chemical synthesis: It can also be used in organic synthesis reactions, such as the synthesis of organic dyes, photosensitive compounds, etc.

Method:
2,3-dihydro -1H-indole -6-formamide has many preparation methods, and the common methods are as follows:
-can be obtained by the reaction of 2-aminoindole with formyl chloride.
-It can also be obtained by the condensation reaction of 2,3-dihydro-1H-indole with amide compounds.

Safety Information:
Under correct handling and storage conditions, 2,3-dihydro-1H-indole-6-carboxamide is relatively safe. However, as chemicals, the following should be noted:
-Wear appropriate personal protective equipment, such as lab gloves and glasses, to avoid direct contact.
-Avoid inhaling the dust or vapor of the compound and operate in a well-ventilated environment.
-Store properly in a sealed container, away from fire and oxidizing agents.
-In case of accidental contact or misuse, seek medical help immediately and bring the relevant safety data sheet for your doctor's reference.

Please note that when conducting chemical experiments or using chemicals, relevant safety operating procedures must be strictly followed and carried out under the guidance of professionals.

Last Update：2024-04-09 20:45:29