ispronicline
Ispronicline
CAS: 252870-53-4
Molecular Formula: C14H22N2O
ispronicline - Names and Identifiers
ispronicline - Physico-chemical Properties
| Molecular Formula | C14H22N2O |
| Molar Mass | 234.34 |
| Density | 0.977±0.06 g/cm3(Predicted) |
| Boling Point | bp0.5 90-100° |
| pKa | 10.03±0.10(Predicted) |
| Storage Condition | -20℃ |
| Use | Ispronicline, also known as AZD3480; TC 1734; TC-0173, and RJR 1734, is a alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties. Ispronicline is potentially useful for the treatment of attention-deficit/hyperactivity disorder in adults. |
ispronicline - Reference
| Reference Show more | 1: Buoli M, Serati M, Cahn W. Alternative pharmacological strategies for adult ADHD treatment: a systematic review. Expert Rev Neurother. 2016;16(2):131-44. doi: 10.1586/14737175.2016.1135735. Review. PubMed PMID: 26693882. 2: Gabrielsson J, Peletier LA. Dose-response-time data analysis involving nonlinear dynamics, feedback and delay. Eur J Pharm Sci. 2014 Aug 1;59:36-48. doi: 10.1016/j.ejps.2014.04.007. PubMed PMID: 24751673. 3: Levin ED. Nicotinic attention-deficit/hyperactivity disorder treatment. Biol Psychiatry. 2014 Feb 1;75(3):174. doi: 10.1016/j.biopsych.2013.11.024. PubMed PMID: 24370349. 4: Potter AS, Dunbar G, Mazzulla E, Hosford D, Newhouse PA. AZD3480, a novel nicotinic receptor agonist, for the treatment of attention-deficit/hyperactivity disorder in adults. Biol Psychiatry. 2014 Feb 1;75(3):207-14. doi: 10.1016/j.biopsych.2013.06.002. PubMed PMID: 23856296. 5: Rezvani AH, Cauley MC, Johnson EC, Gatto GJ, Levin ED. Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats. Psychopharmacology (Berl). 2012 Oct;223(3):251-8. doi: 10.1007/s00213-012-2712-2. PubMed PMID: 22526540. 6: Jacobsen J, Hansen HH, Kiss A, Mikkelsen JD. The α4β2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain. Neurosci Lett. 2012 Apr 25;515(1):7-11. doi: 10.1016/j.neulet.2012.02.081. PubMed PMID: 22414858. |
ispronicline - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.267 ml | 21.336 ml | 42.673 ml |
| 5 mM | 0.853 ml | 4.267 ml | 8.535 ml |
| 10 mM | 0.427 ml | 2.134 ml | 4.267 ml |
| 5 mM | 0.085 ml | 0.427 ml | 0.853 ml |
Last Update：2024-01-02 23:10:35
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