k-flebo
CAS: 14007-45-5
Molecular Formula: C4H8KNO4
k-flebo - Names and Identifiers
k-flebo - Physico-chemical Properties
| Molecular Formula | C4H8KNO4 |
| Molar Mass | 173.21 |
k-flebo - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | CI9479000 |
| FLUKA BRAND F CODES | 3 |
k-flebo - Precursor of oxaloacetic acid
Potassium is the main cation in the cell. It is necessary for cell survival and has a variety of physiological functions. 98% potassium exists in the cell, and the extracellular fluid contains only 2%. The potassium in the extracellular fluid mainly exists in the ionic state. In addition to the potassium in the intracellular fluid divided by the ionic state, one part is bound to protein, and the other part is bound to sugar and phosphate. Hypokalemia (hypokalemia) refers to serum potassium concentration below 3.5 mmol /L. A variety of clinical reasons can cause hypokalemia, such as insufficient eating, vomiting, severe diarrhea, application of potassium excretion diuretics, potassium loss nephropathy and long-term use of glucocorticoids and hypertonic glucose supplementation. Low potassium can affect the resting potential of the myocardial cell membrane, promote differential conduction and reentry, form severe arrhythmia, and increase the incidence of digitalis poisoning; at the same time, it can cause muscle weakness, paralysis, respiratory insufficiency and other neuromuscular disorders. It can also lead to rhabdomyolysis, abnormal electrocardiogram and intestinal obstruction. Long-term hypokalemia leads to renal tubular injury (hypokalemic nephropathy). The main cause of hypokalemia is the loss of total potassium in the body, which is called potassium deficiency (potassium depletion). Clinically, even if the total potassium in vivo is not lacking, it can also lead to a decrease in serum potassium due to dilution or transfer to cells. The clinical manifestations of hypokalemia lack characteristics, early detection, in addition to active treatment of the primary disease, should pay attention to timely potassium supplementation. Aspartate has a strong affinity for cells and can transport potassium ions most effectively. It is a good carrier for potassium ions to enter cells. Potassium aspartate is a new potassium supplement drug developed on the basis of this theory.
Potassium aspartate is the precursor of oxaloacetic acid, which can play an important role in the tricarboxylic acid cycle and ammonia metabolism. It also plays an important role in the synthesis of purine bodies and pyrimidine bodies, and these two help Nucleic acid and ATP synthesis. Potassium aspartate is converted into other non-essential free amino acids in liver and brain mitochondria. Its efficacy has both biochemical effects and potassium ion effects. The two complement each other and synergize. And experiments show that aspartate as a carrier is longer than DL- Glu (glutamic acid) as a carrier in vivo. Potassium and aspartic acid are both substances in the body, and appropriate application has no genotoxicity and potential carcinogenicity. Potassium aspartate is a colorless or nearly colorless clear liquid, no impurities, and is an electrolyte supplement. It is used for hypokalemia caused by various reasons, periodic limb paralysis caused by hypokalemia, and digitalis poisoning Arrhythmia. Its main components are potassium aspartate and potassium L-2-aminosuccinate.
Last Update：2024-04-10 22:29:15
k-flebo - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | is a pharmaceutical intermediate that can be used as a food additive and biochemical research preparation |
Last Update：2024-04-09 21:01:54
k-flebo - Uses and synthesis methods
Pharmacokinetics
widely distributed, widely distributed in liver, kidney, blood, heart and other parts; 90% is excreted by the kidney following urine, and 10% by the intestine following feces.
indications
Electrolyte supplements are used for hypokalemia caused by various reasons; periodic limb paralysis caused by hypokalemia; arrhythmia caused by digitalis poisoning.
In addition, potassium aspartate provides more ATP for the body to supplement potassium, which can maintain cell function, cell regeneration, enhance body immunity, promote healing, reduce infection rate, and maintain acid-base balance in the body.
adverse reactions
1. it is easy to stimulate veins to cause pain and even phlebitis.
2, hyperkalemia. It is easy to occur when excessive application, fast speed or original renal function damage, manifested as weakness, fatigue, numbness of hands, feet, mouth and lips, anxiety, confusion, difficulty breathing, slow heart rate, arrhythmia, conduction block, and even cardiac arrest.
drug interactions
1. Hyperkalemia is likely to occur when combined with potassium-sparing diuretics or angiotensin-converting enzyme inhibitors.
2. When combined with stock blood with increased potassium content, hyperkalemia is prone to occur.
precautions
1. No direct intravenous injection, no intravenous drip without dilution.
2. patients with renal impairment and atrioventricular block should be used with caution.
3. Pay attention to the changes of electrolytes and electrocardiogram in blood.
taboo
1. Patients with hyperkalemia and acute and chronic severe renal dysfunction are contraindicated.
2. should be used with caution in patients with adrenal hypofunction, atrioventricular block, cardiogenic shock, acute dehydration and hyperkalemia.
incompatibility
potassium aspartate is incompatibility with various trace element injections (II). In clinical work, nurses should try to avoid the continuous input of two drugs into the human body, and at the same time, an appropriate amount of normal saline or glucose solution should be injected between the two liquids, so as to avoid the incompatibility of direct and continuous intravenous drip of the two liquids, prevent the occurrence of infusion reactions, and avoid unnecessary damage to patients.
Last Update：2024-04-09 21:54:55
