Name | clorsulon |
Synonyms | l631529 curatrem clorsulon keluosuolong 4-amino-6-(trichlorovinyl)-m-benzenedisulfonamide 4-AMINO-6-(TRICHLOROVINYL)-M-BENZENEDISULFONAMIDE 4-AMINO-6-TRICHLOROVINYL-1,3-BENZENEDISULFONAMIDE 4-amino-6-(trichlorovinyl)-1,3-benzenedisulfonamide 4-amino-6-(trichloroethenyl)-3-benzenedisulfonamide 4-amino-6-(trichloroethenyl)benzene-1,3-disulfonamide 4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide 4-AMINO-6-(TRICHLORO-ETHENYL)-1,3-BENZENEDISULFONAMIDE 1,3-Benzenedisulfonamide, 4-amino-6-(trichloroethenyl)- |
CAS | 60200-06-8 |
EINECS | 262-100-2 |
InChI | InChI=1/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18) |
Molecular Formula | C8H8Cl3N3O4S2 |
Molar Mass | 380.66 |
Density | 1.800±0.06 g/cm3(Predicted) |
Melting Point | 194-203°C |
Boling Point | 651.7±65.0 °C(Predicted) |
Flash Point | 348°C |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Vapor Presure | 7.24E-17mmHg at 25°C |
Appearance | neat |
Color | White |
pKa | 9.16±0.60(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
Refractive Index | 1.664 |
Use | This product is for scientific research only and shall not be used for other purposes. |
In vitro study | Clorsulon is a competitive inhibitor of 3-phosphoglycerate and ATP, with a K I of 0.29 mM, and in vitro, inhibits glucose utilization and acetate and propionate formation in mature F. Hepatica. |
In vivo study | Clorsulon (a single dose of 15 mg/kg) was effective in removing more than 90% of immature F. Hepaticus in sheep (6 weeks post-infection) and cattle (8 weeks post-infection). A dose of 2.5 mg/kg was able to remove more than 90% of mature (16-week-old) liver fluks in sheep. After in vivo incubation, Clorsulon severely damages the cortex and viscera of F. Hepaticus. |
Safety Description | 24/25 - Avoid contact with skin and eyes. |
WGK Germany | 2 |
RTECS | CZ9090000 |
HS Code | 29350090 |
Toxicity | LD50 in mice (mg/kg): 761 i.p.; >10,000 orally (Ostlind) |
biological activity | Clorsulon (MK-401) was used to treat Fasciola hepatica infection in calves and sheep. |
Usage | is an anti-schistosome drug, which can be used to treat schistosomiasis. |