Name | LIDOFLAZINE |
Synonyms | klinium clinium lidoflazin corflazine mcn-jr7904 LIDOFLAZINE lidoflazina lidoflazinum 6'-xylidide,4-(4,4-bis(p-fluorophenyl)butyl)-1-piperazineaceto-2 |
CAS | 3416-26-0 |
EINECS | 222-312-8 |
Molecular Formula | C30H35F2N3O |
Molar Mass | 491.62 |
Density | 1.1322 (estimate) |
Melting Point | 159-161° |
Boling Point | 632.6±55.0 °C(Predicted) |
Solubility | DMSO: ≥10mg/mL |
Appearance | powder |
Color | white |
pKa | 14.62±0.70(Predicted) |
Storage Condition | 2-8°C |
In vitro study | Lidoflazine inhibits potently HERG current (IHERG) recorded from HEK 293 cells stably expressing wild-type HERG (IC 50 of ~16 nM). |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
Safety Description | 36 - Wear suitable protective clothing. |
WGK Germany | 3 |
RTECS | TK7910000 |
biological activity | lidoflavine is a high affinity blocker of the HERG K channel. Lidoflavine is also an anti-anginal calcium channel blocker with a significant risk of prolonging the QT interval and developing ventricular arrhythmias. |