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m-Aldehydophenol

3-Hydroxybenzaldehyde

CAS: 100-83-4

Molecular Formula: C7H6O2

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m-Aldehydophenol - Names and Identifiers

Name 3-Hydroxybenzaldehyde
Synonyms m-Formylphenol
m-Aldehydophenol
hydroxybenzaldehyde
HYDROXYBENZALDEHYDE-3
m-hydroxy-benzaldehyd
m-Hydroxybenzaldehyde
3-hydroxy-benzaldehyd
3-Hydroxydenzaldehyde
3-Hydroxybenzaldehyde
m-hydroxy benzaldehyde
3-hydroxy benzaldehyde
Benzaldehyde, m-hydroxy-
META-HYDROXY BENZALDEHYDE
4-hydroxy-3-(3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl)benzoic acid
CAS 100-83-4
EINECS 202-892-9
InChI InChI=1/C7H6O2/c8-5-6-2-1-3-7(9)4-6/h1-5,9H
InChIKey IAVREABSGIHHMO-UHFFFAOYSA-N

m-Aldehydophenol - Physico-chemical Properties

Molecular FormulaC7H6O2
Molar Mass122.12
Density1.1179
Melting Point100-103°C(lit.)
Boling Point191°C50mm Hg(lit.)
Flash Point191°C/50mm
Water SolubilitySOLUBLE
Solubility Slightly soluble in water, soluble in hot water; ethanol; acetone; ether and benzene. Can sublimate, not steam distillation.
Vapor Presure2.09E-24mmHg at 25°C
AppearanceSlightly brown crystalline powder
Colorfaintly yellow to light brown
BRN507099
pKa8.98(at 25℃)
PH3-4 (H2O, 20℃)(saturated solution)
Storage ConditionInert atmosphere,2-8°C
SensitiveAir Sensitive
Refractive Index1.5286 (estimate)
MDLMFCD00003368
Physical and Chemical PropertiesMelting point 101-105°C
boiling point 191°C (50 mmHg)
water-SOLUBLE solution
UseFor the synthesis of pharmaceuticals, dyes and organic compounds

m-Aldehydophenol - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
S24/25 - Avoid contact with skin and eyes.
WGK Germany3
RTECSCU6450000
FLUKA BRAND F CODES8-9-23
TSCAYes
HS Code29124900

m-Aldehydophenol - Upstream Downstream Industry

Raw Materialsm-Cresol
Downstream Products3-Hydroxybenzyl alcohol

m-Aldehydophenol - Reference

Reference
Show more
1. Shan Wang, Chen Yongsheng, Liang Xiaowei, et al. Synthesis of Hydroxycinnamic Acid Derivatives and Their Antioxidant Structure-Activity Relationship [J]. Food Industry Science and Technology, 2017(12):293-297 338.

m-Aldehydophenol - Nature

Open Data Verified Data

colorless or light yellow crystalline solid, melting point 103~104 ℃, boiling point 240 ℃,191 ℃(6. 7kPa). Slightly soluble in water, soluble in hot water, ethanol, acetone, ether and benzene. Can sublimate, can not be water vapor distillation.

Last Update:2024-01-02 23:10:35

m-Aldehydophenol - Preparation Method

Open Data Verified Data

with the preparation of M-nitrobenzaldehyde, there are two methods of synthesis.

Last Update:2022-01-01 10:42:26

m-Aldehydophenol - Introduction

Sensitive to light and air. Can sublimate. Soluble in ethanol, ether, acetone, benzene and hot water, slightly soluble in cold water, insoluble in petroleum. It's irritating.
Last Update:2022-10-16 17:11:19

m-Aldehydophenol - Safety

Open Data Verified Data

its gas forms an explosive mixture with air. Combustion produces irritant, corrosive and/or toxic gases. Inhalation, ingestion and skin contact are harmful. Wear glasses, protective clothing and protective gloves. Packaged in cardboard barrels, 25kg net weight per barrel.

Last Update:2022-01-01 10:42:26

m-Aldehydophenol - Reference Information

NIST chemical information Information provided by: webbook.nist.gov (external link)
EPA chemical information Information provided by: ofmpub.epa.gov (external link)
uses used in the synthesis of medicines, dyes and organic compounds
m-hydroxybenzaldehyde is used as an intermediate for fine chemicals such as medicines, dyes, fungicides, photographic emulsifiers, etc.
as an intermediate, m-hydroxybenzaldehyde is mainly used in the manufacture of medicine, spices and dyes. It can also be used in fungicides, photographic emulsifiers, nickel-plated gloss agents, etc. The drugs synthesized by m-hydroxybenzaldehyde mainly include hydrochloric acid dehydroxyadrenal gland, epinephrine, quinine, otocaine, etc.
Schiff's reagent (Schiff's reagent). Pharmaceutical, plastic, dye intermediates. Fungicide. Photographic emulsifier.
production method using m-nitrobenzaldehyde as raw material, there are two methods for preparing m-hydroxybenzaldehyde. 1. It is obtained by addition, reduction, diazotization and hydrolysis of m-nitroformaldehyde. Dissolve sodium bisulfite in water, add m-nitrobenzaldehyde, and stir and dissolve at 50°C to obtain the adduct. The adduct exists in calcium carbonate, heated and refluxed with ferrous sulfate for 3h, and reduced to amino. The reduction liquid is cooled to below 15 ℃, diazotized with sodium nitrite solution dropwise, and then hydrolyzed at 100-110 ℃ to obtain m-hydroxybenzaldehyde. After decolorization of activated carbon and recrystallization with water, the finished product is obtained. 2. It is obtained by reduction of m-nitrobenzaldehyde by stannous chloride, diazotization and hydrolysis. Mix powdered stannous chloride dihydrate with hydrochloric acid into a solution, cool to 5 ℃, and add m-nitrobenzaldehyde. After slowly heating to 25-30 ℃, the temperature rises rapidly. When it rises to 100 ℃, it is cooled and stirred vigorously to obtain orange paste. Add concentrated hydrochloric acid to form a suspension, slowly add sodium nitrite aqueous solution under stirring, and control the temperature at 4-5 ℃. After adding, stir for 1h. Cooling crystallization, filtering out diazonium salt, adding to boiling water for hydrolysis, and decolorizing with activated carbon. Filter while hot, cool and crystallize to obtain the finished product.
Last Update:2024-04-09 21:40:26
m-Aldehydophenol
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View History
m-Aldehydophenol
(3-bromophenyl)thiourea
8-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-8-AZASPIRO[4,5]DECANE-7,9-DIONE HYDROCHLORIDE
芹菜籽油
2-propylpentyl 14-methylpentadecanoate
四丁基二醋酸铵
Seabuckthorn Fruit Extract
邻乙酰胺基-N-乙酰基苯磺酰胺
ETHYL OXAZOLE-5-CARBOXYLATE
纤维粘连蛋白
Raw Materials for m-Aldehydophenol
m-Cresol
Downstream Products for m-Aldehydophenol
3-Hydroxybenzyl alcohol
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