metaprel

Name	Metaproterenol Sulfate
Synonyms	alotec metaprel novasmasol Metaproterenol Sulfate 1-(3,5-dihydroxyphenyl)-2-(isopropylamino)ethanolsulfate 1-(3,5-dihydroxyphenyl)-1-hydroxy-2-isopropylaminoethanesulfate 3,5-dihydroxy-alpha-((isopropylamino)methyl)benzylalcoholsulfate
CAS	5874-97-5
EINECS	227-539-6

Molecular Formula	C22H36N2O10S
Molar Mass	520.59
Melting Point	202-203°
Solubility	Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
Appearance	neat
Color	White to Off-White
Storage Condition	2-8°C
Stability	Hygroscopic
In vivo study	Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.

Hazard Symbols	Xn - Harmful
Risk Codes	20 - Harmful by inhalation
Safety Description	36 - Wear suitable protective clothing.
WGK Germany	2
RTECS	DO2275000
HS Code	2922504500
Toxicity	LD50 in rats (mg/kg): 42 orally (Goldenthal)

, it is a β2-adrenergic receptor (β2AR) agonist with an IC50 of 68 nM. Metaproterenol hemisulfate also has anti-inflammatory activity.

biological activity
Target	IC50: 68 nM
Cell Line:	THP-1 cells and bone marrow macrophages THP-1 cells and bone marrow macrophages
Concentration:	10 μM 10 μM
Incubation Time:	74 hours 74 hours
Result:	Enhanced β-arrestin2 and its interaction with IκBα. Led to downregulation of NF-κB.

Last Update：2024-04-09 21:01:54

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QQ: 3008007409

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