Molecular Formula | C27H33NO10S |
Molar Mass | 563.62 |
Density | 1.2222 (rough estimate) |
Melting Point | 190-198?C |
Boling Point | 929.6±65.0 °C(Predicted) |
Specific Rotation(α) | D -609° (water), -240° (ethanol) |
Solubility | Soluble in organic solvents such as DMSO. |
Appearance | Light yellow fine powder |
Storage Condition | 2-8℃ |
Refractive Index | 1.655 |
MDL | MFCD07995056 |
invention patent
Application (patent) number:
CN201810299376.5
application date:
20180404
Public/Announcement Number:
CN108864220A
Public/announcement date:
20181123
applicant (patent):
tiershi (Nanjing) drug R & D Co., Ltd.
inventor:
copper-butadiene lock , Zhang Dongdong , Hu Yongzhu , Liu Chun , Cui Xilin
National and provincial code:
CN320111
Abstract:
The invention discloses a preparation method of thiocolchicine impurity, which belongs to the field of drug synthesis, and the whole process design is reasonable, the operability is strong, and the purification is convenient. The invention uses thiocolchicine glucoside as a starting material, and obtains thiocolchicine glucoside impurity through four-step reaction synthesis. The invention selects the optimal preparation steps and reaction conditions through experiments, the purity of the prepared thiocolchicine impurity is more than 98%, which provides a test sample for thiocolchicine research and has important research value in clinical pharmacokinetic research.
CN 201280035445
application date:
Jun 15, 2012
Public/Announcement Number:
CN 103702667 A
applicant (patent):
elpi Pharmaceutical Co., Ltd.
inventor:
National and provincial code:
Italy; IT
Abstract:
The present invention relates to a patch for the transdermal delivery of diclofenac or a pharmaceutically acceptable salt thereof, particularly diethylamine salt and thiocolchicine.
sovereignty:
1. A patch comprising diclofenac or a pharmaceutically acceptable salt thereof, thiocolchicoside and optionally a pharmaceutically acceptable excipient dispersed in an adhesive matrix.
CN200680026727.0
application date:
2006-07-20
Public/Announcement Number:
CN101228175
applicant (patent):
indner limited
inventor:
G · Fontana ,E · bonbardl A · Riva ,P · morazoni ,D · Pocar M · L · Germi G · ponteremoly
National and provincial code:
Italy
Abstract:
The present invention relates to 3-desmethoxy-3-aminothiocolchicine glycosyl derivatives of general formula (I), wherein R is hydrogen, methyl or hydroxymethyl. The compounds of formula (I) have muscle relaxant and anti-inflammatory activity.
sovereignty:
1. Compounds of general formula (I): wherein R is hydrogen, methyl or hydroxymethyl.