n-(aminoiminomethyl)-4-morpholinecarboximidamide
moroxydine
CAS: 3731-59-7
Molecular Formula: C6H13N5O
n-(aminoiminomethyl)-4-morpholinecarboximidamide - Names and Identifiers
| Name | moroxydine |
| Synonyms | moroxydine MOROXYDINUM TIMTEC-BB SBB003847 1-(1-morpholinoformimidoyl)guanidine N-(morpholine-4-carboximidoyl)guanidine N-carbamimidoylmorpholine-4-carboximidamide n-(aminoiminomethyl)-4-morpholinecarboximidamide N-(diaminomethylidene)-4-morpholinecarboximidamide hydrochloride |
| CAS | 3731-59-7 |
| EINECS | 223-093-1 |
| InChI | InChI=1/C6H13N5O/c7-5(8)10-6(9)11-1-3-12-4-2-11/h1-4H2,(H5,7,8,9,10) |
n-(aminoiminomethyl)-4-morpholinecarboximidamide - Physico-chemical Properties
| Molecular Formula | C6H13N5O |
| Molar Mass | 171.2 |
| Density | 1.51±0.1 g/cm3(Predicted) |
| Melting Point | 211-214°C(lit.) |
| Boling Point | 274.0±50.0 °C(Predicted) |
| Flash Point | 151.6°C |
| Vapor Presure | 0.000207mmHg at 25°C |
| Merck | 13,6295 |
| pKa | 13.01±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.661 |
| Physical and Chemical Properties | White crystalline powder. Melting point 206-212 °c (decomposition). Soluble in water, ethanol-soluble, ether, almost insoluble in chloroform. No odor, slightly bitter taste. |
| Use | Mainly used for the prevention and treatment of influenza, mumps, viral bronchitis, chicken pox, herpes, epidemic red eye disease |
n-(aminoiminomethyl)-4-morpholinecarboximidamide - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
n-(aminoiminomethyl)-4-morpholinecarboximidamide - Upstream Downstream Industry
| Raw Materials | Charcoal Dicyandiamide Hydrochloric acid Ethyl Alcohol |
n-(aminoiminomethyl)-4-morpholinecarboximidamide - Reference Information
| overview | moroxydine can effectively resist some common DNA and RNA viruses. it is cheap and easy to synthesize. it has been widely used in the treatment of epidemic diseases, such as influenza, mild viral infection, etc. in the era of lack of medicine and medicine, so it has obtained a more popular name "virus spirit". The chemical structure of ABOB was first invented by the foreign Kabi company in 1950. At that time, it came out as a new oral drug for the treatment of influenza. After intramuscular injection, the oral form of the preliminary test drug has been proved to be equally effective. Clinical research reports show that ABOB can at least shorten the course of 1/3 influenza. Most influenza patients recover within four days, while treatment usually takes six days. In preventive drug trials, the report shows that it can reduce the number of influenza cases by 80%. Therefore, ABOB is a broad-spectrum antiviral drug. It has an active inhibitory effect on all aspects of the proliferation phase of various viruses such as viral influenza and respiratory viruses. In addition, it also has an inhibitory effect on many potential RNA and DNA viruses. |
| mechanism of action | moroxydine (ABOB) can inhibit virus DNA and RNA polymerase, thereby inhibiting virus reproduction, but its specific pharmacological mechanism is not yet fully understood. It is mainly used for the prevention and treatment of influenza clinically. In vitro pharmacological studies have shown that 1% concentration of ABOB has obvious inhibitory effect on DNA virus (adenovirus, herpes virus) and RNA virus (Echo virus). It has inhibitory effect on all stages of virus proliferation cycle, but has no direct effect on free virus particles. |
| use | this product is an antiviral drug. It has an antiviral effect by inhibiting the synthesis of nucleic acids and lipoproteins, and is effective against influenza A2 and B viruses. Mainly used to prevent and treat influenza, mumps, viral bronchitis, chickenpox, herpes, epidemic pink eye, etc. |
| production method | is obtained by adding morpholine (see 25940) hydrochloride and dicyandiamide. Heat 80-85% of morpholine hydrochloride concentrated solution with xylene, stir and reflux with water to the end. After cooling, add dicyandiamide, heat up, and when the intense reaction starts, stop heating immediately. After the reaction eased, the reflux continued for 3 hours. Steam out xylene, add water to dissolve, decolorize with activated carbon, and then soak and wash the obtained crude product with ethanol, and dry to obtain the finished product. The yield is about 70%. |
Last Update：2024-04-09 15:16:50
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Raw Materials for n-(aminoiminomethyl)-4-morpholinecarboximidamide