n-t-butoxycarbonylpiperazine
1-boc-piperazine
CAS: 57260-71-6;146398-94-9
Molecular Formula: C9H18N2O2
n-t-butoxycarbonylpiperazine - Names and Identifiers
n-t-butoxycarbonylpiperazine - Physico-chemical Properties
| Molecular Formula | C9H18N2O2 |
| Molar Mass | 186.25 |
| Density | 1.030±0.06 g/cm3(Predicted) |
| Melting Point | 47-49℃ |
| Boling Point | 258°C at 760 mmHg |
| Flash Point | 109.8°C |
| Water Solubility | Soluble in ethyl acetate, methanol and water. |
| Vapor Presure | 0.0141mmHg at 25°C |
| Appearance | Low Melting Crystalline Mass |
| Color | White to light yellow |
| BRN | 879985 |
| pKa | 8.45±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Sensitive | Air Sensitive |
| Use | In modern chemical pharmaceuticals, 1-tert-butoxycarbonylpiperazine plays a very important role, because it is an important basic chemical raw material for many antitussive drugs, anti-allergic drugs, antipsychotic drugs, antibacterial drugs, various pesticides, etc. Due to its wide range of uses, increasing demand, accounting for a high proportion of the cost of various drugs, so reducing the industrialization cost of 1-tert-butoxycarbonylpiperazine has very important industrial value and economic value. |
n-t-butoxycarbonylpiperazine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 3263 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 3-10-34 |
| HS Code | 29335995 |
| Hazard Class | IRRITANT |
n-t-butoxycarbonylpiperazine - Introduction
Use
1-tert-butoxycarbonylpiperazine is a useful organic synthetic compound.
Application
N-Boc-piperazine can be used to prepare the downstream product 1-[5-(trifluoromethyl)-2-pyridyl] piperazine.
Synthesis method
At present, the method of synthesizing 1-tert-butoxycarbonylpiperazine is mainly to use anhydrous piperazine drops and ditert-butyl dicarbonate to selectively react to protect the nitrogen on one end of piperazine, so that the amino group on the other end is removed. In this reaction method, both ends of piperazine will be connected with ditert-butyl dicarbonate, and a large amount of water must be used for purification. Wash.
Use as an organic intermediate
Last Update：2024-04-09 20:52:54
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