nitrosoglutathione(GSNO)
S-Nitroso-L-glutathione
CAS: 57564-91-7
Molecular Formula: C10H16N4O7S
nitrosoglutathione(GSNO) - Names and Identifiers
| Name | S-Nitroso-L-glutathione |
| Synonyms | RVC 588 RVC 588 (peptide) S-Nitrosylglutathione S-Nitroso-L-glutathione nitrosoglutathione(GSNO) L-γGlu-S-Nitroso-L-Cys-Gly-OH L-γ-GlutaMyl-S-nitroso-L-cysteinyl-glycine N-(N-L-gama-glutamyl-S-nitroso-L-cysteinyl)glycine (S)-2-aMino-5-(((R)-1-((carboxyMethyl)aMino)-3-(nitrosothio)-1-oxopropan-2-yl)aMino)-5-oxopentanoic acid |
| CAS | 57564-91-7 |
| EINECS | 637-341-5 |
| InChI | InChI=1/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/p-1/t5-,6-/m0/s1 |
nitrosoglutathione(GSNO) - Physico-chemical Properties
| Molecular Formula | C10H16N4O7S |
| Molar Mass | 336.32 |
| Density | 1.68 |
| Melting Point | >170°C (dec.) |
| Solubility | DMSO (Slightly), Water (Slightly) |
| Appearance | Pink solid |
| Color | Off-White to Pink |
| pKa | 2.21±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Hygroscopic |
| Refractive Index | 1.6000 (estimate) |
nitrosoglutathione(GSNO) - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | MC0558000 |
nitrosoglutathione(GSNO) - Introduction
S-Nitroso-L-glutathione(S-Nitroso-L-glutathione) is a natural compound containing a nitroso (NO) functional group. It is formed by the reaction of glutathione (a tripeptide) with a molecule of NO. S-Nitroso-L-glutathione is widely present in organisms and can release NO in cells, thus participating in a variety of physiological and pathological processes.
S-Nitroso-L-glutathione has certain physiological activities, including antioxidant, anti-inflammatory, neuromodulation, apoptosis and other biological functions. It can regulate vasodilation and contraction and regulate blood circulation through the release of NO. In addition, S-Nitroso-L-glutathione can also affect the process of inflammatory response, apoptosis and platelet aggregation by regulating cell signaling pathways.
The common method for preparing S-Nitroso-L-glutathione is obtained by reacting glutathione with nitrite. The preparation process requires control of the reaction conditions to ensure purity and yield.
Regarding the safety of S-Nitroso-L-glutathione, studies have shown that it has low toxicity and good biocompatibility. However, more research is needed to determine its safety in the long-term use of high doses. It should be noted that S-Nitroso-L-glutathione is an easily oxidized compound and should be stored in a dry, cool environment and avoid contact with oxygen and photosensitizing substances.
S-Nitroso-L-glutathione has certain physiological activities, including antioxidant, anti-inflammatory, neuromodulation, apoptosis and other biological functions. It can regulate vasodilation and contraction and regulate blood circulation through the release of NO. In addition, S-Nitroso-L-glutathione can also affect the process of inflammatory response, apoptosis and platelet aggregation by regulating cell signaling pathways.
The common method for preparing S-Nitroso-L-glutathione is obtained by reacting glutathione with nitrite. The preparation process requires control of the reaction conditions to ensure purity and yield.
Regarding the safety of S-Nitroso-L-glutathione, studies have shown that it has low toxicity and good biocompatibility. However, more research is needed to determine its safety in the long-term use of high doses. It should be noted that S-Nitroso-L-glutathione is an easily oxidized compound and should be stored in a dry, cool environment and avoid contact with oxygen and photosensitizing substances.
Last Update：2024-04-09 21:54:55
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