Molecular Formula | C28H37NO9
|
Molar Mass | 531.59 |
Density | 1.35±0.1 g/cm3(Predicted) |
Melting Point | 73-75°C°C |
Boling Point | 679.4 °C at 760 mmHg |
Solubility | It is easy to decompose in alkaline solution. Easily soluble in methanol, ethanol or chloroform, slightly soluble in water and ether |
Appearance | White solid |
pKa | 11.62±0.29(Predicted) |
Storage Condition | 2-8℃ |
MDL | MFCD28978177 |
Physical and Chemical Properties | Physico-chemical properties harringtonine is an extract of Cephalotaxus. White crystalline or yellowish amorphous powder, bitter in taste, with hygroscopicity, dark in light. It is easy to decompose in alkaline solution. Soluble in methanol, ethanol or chloroform, water-soluble and ether. The melting point was 72-74 °c. [Α] d 25 -120 °(C = 0.2,CHCl3). |
Use | Uses harringtonine is a natural alkaloid compound with anti-tumor properties and is also a translation inhibitor. It inhibits protein synthesis at low micromolar concentrations, immobilizes ribosomes immediately after translation begins, and although harringtonine has some effect in reducing cancer, its homolog, homolog, homolog, is more effective, especially for chronic myelogenous leukemia. The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-protected mRNA fragments to assess translation. |