o-Anisaldehyde
o-Anisaldehyde
CAS: 135-02-4
Molecular Formula: C8H8O2
o-Anisaldehyde - Names and Identifiers
| Name | o-Anisaldehyde |
| Synonyms | o-Anisaldehyde o-Anisic Aldehyde ortho-anisaldehyde O-Methoxybenzaldehyde 2-methoxy-benzaldehyd 2-Methoxybenzaldehyde O-Methoxylbenzaldehyde MethoxybenzaldehydeAnisaldehyd 2-Methoxybenzenecarboxaldehyde Adjacent Methoxy benzene forMaldehyde o-Anisaldehyde 〔o-Methoxybenzaldehyde〕 2-MethoxybenzaldehydeSalicylaldehyde Methyl Ether |
| CAS | 135-02-4 |
| EINECS | 205-171-7 |
| InChI | InChI=1/C8H8O2/c1-10-8-5-3-2-4-7(8)6-9/h2-6H,1H3 |
o-Anisaldehyde - Physico-chemical Properties
| Molecular Formula | C8H8O2 |
| Molar Mass | 136.15 |
| Density | 1.127g/mLat 25°C(lit.) |
| Melting Point | 34-40°C(lit.) |
| Boling Point | 238°C(lit.) |
| Flash Point | 244°F |
| JECFA Number | 2062 |
| Water Solubility | insoluble |
| Solubility | Solubility Slightly soluble in water; soluble in ethanol |
| Vapor Presure | 0.00128mmHg at 25°C |
| Appearance | Pale yellow to light brown |
| Specific Gravity | 1.127 |
| Color | Light yellow to pale brown |
| BRN | 606301 |
| Storage Condition | 2-8°C |
| Sensitive | Air Sensitive |
| Refractive Index | 1.5608 |
| MDL | MFCD00003308 |
| Physical and Chemical Properties | Density 1.127 melting point 34-40°C boiling point 238°C refractive index 1.5608 flash point 117°C water-soluble insoluble |
| Use | Useful as an intermediate in fragrances, pharmaceuticals, and fluorescent whitening agents |
o-Anisaldehyde - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36/38 - Irritating to eyes and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 2 |
| RTECS | BZ2610000 |
| FLUKA BRAND F CODES | 9-23 |
| TSCA | Yes |
| HS Code | 29124900 |
| Toxicity | LD50 orally in Rabbit: 2500 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
o-Anisaldehyde - Reference
| Reference Show more | 1. [IF=3.845] Zhang Jie Ying et al."Target Identification of Active Constituents of Shen Qi Wan to Treat Kidney Yang Deficiency Using Computational Target Fishing and Network Pharmacology."Front Pharmacol. 2019 Jun;0:650 |
o-Anisaldehyde - Introduction
Soluble in alcohol, ether, benzene, insoluble in water. It is yellow when it reacts with sulfuric acid.
Last Update：2022-10-16 17:13:33
o-Anisaldehyde - Reference Information
| FEMA | 4077 | O-ANISALDEHYDE |
| pH indicator color change ph range | Non1 uorescence (3.1) to green 1 uorescence (4.4) |
| main applications | Battery, hair dyes, bird repellents, cosmetics, antibacterial, antipyretic |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | o-methoxybenzaldehyde is used to synthesize stilbene and dihydrostilbene derivatives as potential anti-cancer drugs. It is also used to synthesize highly functionalized pyrrolidine as a potent angiotensin converting enzyme inhibitor. This product is an organic synthesis intermediate, used in the production of spices and medicines. O-methoxy formaldehyde can be used in production. O-methoxybenzaldehyde can be used to produce the adrenergic drug Qiaoxining. It is used as an intermediate of perfume, medicine and fluorescent whitening agent It is the main intermediate for synthesizing fluorescent whitening agent CBS, triphenylmethane dye and moth prevention agent N 2-methoxybenzaldehyde is an organic synthesis intermediate, which is used in the production of perfume and medicine. O-methoxy formaldehyde can be used in production. O-methoxybenzaldehyde can be used in the production of the adrenergic drug Qiankening. |
| Production method | Made by methylation reaction of salicylaldehyde with dimethyl sulfate. Mix 3kg of sodium hydroxide into a 30% aqueous solution, add 12.2kg of salicylaldehyde and 80L of water solution under stirring, and heat until boiling. Add 12.9kg of dimethyl sulfate slowly, keep the reaction solution under reflux for about 3 hours, continue to reflux for 2-3 hours, cool the oil layer, wash with 5% sodium hydroxide solution, then wash with water until pH 8, add anhydrous potassium carbonate and dry. After filtering out the desiccant, it is distilled under reduced pressure to collect the fraction at 120 ℃(2.0kPa), which is o-methoxybenzaldehyde. The methylation reaction can also be carried out in the solvent toluene with 60% yields. |
| category | flammable liquid |
| toxicity classification | poisoning |
| acute toxicity | oral-rat LD50: 2500 mg/kg |
| stimulation data | skin-rabbit 500 mg/24 hours moderate |
| flammability hazard characteristics | combustible; combustion produces stimulating smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-09 20:45:29
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View History
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