o-chloro-pheno
O-Chlorophenol
CAS: 95-57-8
Molecular Formula: C6H5ClO
o-chloro-pheno - Names and Identifiers
o-chloro-pheno - Physico-chemical Properties
| Molecular Formula | C6H5ClO | ||||||
| Molar Mass | 128.56 | ||||||
| Density | 1.241 g/mL at 25 °C (lit.) | ||||||
| Melting Point | 8 °C (lit.) | ||||||
| Boling Point | 175-176 °C (lit.) | ||||||
| Flash Point | 147°F | ||||||
| Water Solubility | 28.5 g/L (20 ºC) | ||||||
| Solubility | alcohol: freely soluble | ||||||
| Vapor Presure | 13.3 hPa (50 °C) | ||||||
| Appearance | neat | ||||||
| Color | Clear Colourless to Pale Orange | ||||||
| Merck | 14,2154 | ||||||
| BRN | 1905114 | ||||||
| pKa | 8.49(at 25℃) | ||||||
| Storage Condition | under inert gas (Argon) | ||||||
| Stability | Stable. Hygroscopic. Combustible. Incompatible with oxidizing agents, acid anhydrides, acid chlorides. | ||||||
| Refractive Index | n20/D 1.558(lit.) | ||||||
| Physical and Chemical Properties |
| ||||||
| Use | For pharmaceuticals, pesticides and dyes and other raw materials for organic synthesis |
o-chloro-pheno - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S28A - S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | UN 2021 6.1/PG 3 |
| WGK Germany | 2 |
| RTECS | SK2625000 |
| FLUKA BRAND F CODES | 9 |
| TSCA | Yes |
| HS Code | 29081000 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 orally in rats: 0.67 g/kg (Deichmann) |
o-chloro-pheno - Reference Information
| use | p-chlorophenol is mainly used in pesticide, medicine, dye, plastic and other industries, as well as denatured agent of alcohol and selective solvent of refined mineral oil. It can also be used for microscopic analysis and plant growth promoters. Used to synthesize dyes, react with dilute nitric acid to form 1. dinitroliates are dye intermediates; a variety of dyes can be further synthesized, such as neutral brilliant green BL and so on. It is used to make dyes and drugs, as a denaturant of alcohol and a selective solvent for refined mineral oil. In the pesticide industry, it is mainly used for the synthesis of tripiconine, midacone, wool fungicide, anti-shrein (multifunctional plant growth regulator), propionate phosphorus (systemic insecticide), poisonous mouse phosphorus, Insecticide, mite egg ester (non-systemic acaricide), acaricide ester, acaricide ether; used in the pharmaceutical industry to carboxylate sodium 5-chloro-2-hydroxybenzoate, synthesis of antamine, p-chlorophenoxyisobutyric acid and other drugs; it is also used to synthesize the antioxidant BHA (butyl hydroxyanisole) and so on. o-chlorophenol is an intermediate of the insecticide profenofos. Used in organic synthesis. O-chlorophenol is obtained by phosgenation to obtain o-chlorophenyl chloroformate, which is an intermediate of carbamate insecticides. used in medicine, pesticides and dyes and other organic synthesis raw materials used in medicine, pesticides and dyes and other organic synthesis raw materials |
| production method | p-chlorophenol has various preparation methods, which can be divided into the following types according to different raw materials: (1) phenol direct chlorination method: phenol is directly chlorinated to generate p (o, m) chlorine (benzene) phenol three isomers, which are separated to obtain p-chlorophenol. According to the difference of chlorinating agent and solvent used, it is divided into the following three methods: (a) thioyl chloride method: after heating and melting phenol, cooling to 40 ℃, slowly adding thioyl chloride, adding about 40-45min, stirring for 4h, heating to 30-40 ℃ for 4h, heating to 40-45 ℃ for 4h, absorbing the reaction tail gas with alkali solution, cooling to room temperature after reaction, washing with water, 10% sodium carbonate solution and water in turn, and distilled under reduced pressure, the 110-115 ℃(2.67kPa) fraction was collected to obtain p-chlorophenol. The method also produces 25-30% by-product o-chlorophenol. (B) Benzene solvent method: benzene is used as solvent, chlorine is used as chlorinating agent, and phenol is directly chlorinated to prepare this product. (C) Solvent-free chlorination method: using iron, bromine, etc. as catalysts, chlorine gas is passed into molten phenol, and chlorinated directly to prepare monochlorophenol. After the reaction solution is washed, it is distilled under reduced pressure to collect the fraction with p-chlorophenol content ≥ 95%. (2) p-dichlorobenzene hydrolysis method: using p-dichlorobenzene as raw material and benzene as solvent by hydrolysis with water or alcohol. (3) Chlorination solution mixed with o-chlorophenol and 2, 4-dichlorophenol is obtained by chlorination of sodium phenol. Decompression fractionation, collect 85-132 ℃(2.0kPa) high boiling point fraction, cool it to below 10 ℃, then p-chlorophenol is precipitated and separated. (4) It is obtained by diazotization and copper chloride replacement of p-aminophenol. (1) It is obtained by chlorination and acidification of sodium phenol. Stir the mixture of sodium phenol, water and ice, slowly add sodium hypochlorite solution below 20 ℃, control the temperature below 20 ℃, leave it overnight at room temperature, add concentrated hydrochloric acid under stirring to acidify to pH 2, wash once, then wash with 5% sodium carbonate solution until the pH of the washing solution is 4-5, after cooling, separate out the oil layer, carry out atmospheric fractionation, and then distill under reduced pressure to obtain the finished product. (2) Chlorination of phenol with chlorine. The molten phenol is added to benzene under stirring, and chlorine is introduced at 26±2 ℃ until the relative density of the chlorinated liquid phase reaches 0.954(23-25 ℃). After removing hydrogen chloride, the benzene is steamed out for recovery, steamed to 125 ℃(21.3kPa), cooled to 60 ℃, fractionated under reduced pressure, and collected at 75 ℃(2.67-3.33kPa) to obtain o-chlorophenol. The chlorination reaction also produces p-chlorophenol and 2, 4-dichlorophenol, which are collected as high boiling substances during vacuum fractionation and can be used as by-products after separation. The yield of o-chlorophenol (above 95%) is nearly 50%, and the yield of p-chlorophenol (above 95%) is about 25.5%. o-chlorophenol is a co-product for the production of p-chlorophenol. chlorinated phenol is obtained by chlorination of phenol, and p-chlorophenol and o-chlorophenol can be obtained by separation. |
| chemical properties | o-chlorophenol is a colorless to yellow-brown liquid, m.p.8.7 ℃, B. p.175 ℃,n25D 1.5565, relative density 1.265, the product is slightly soluble in water, soluble in ethanol, ether and alkali solution. |
| category | pesticide |
| toxicity classification | highly toxic |
| acute toxicity | oral-rat LD50: 670 mg/kg; Oral-mouse LD50: 345 mg/kg |
| flammability hazard characteristics | open flame combustible; high heat emits toxic chloride gas |
| storage and transportation characteristics | warehouse ventilation and low temperature drying; Separate storage with oxidant and food additives |
| fire extinguishing agent | mist water, foam, carbon dioxide, sand |
| NIST chemical substance information | The information is: webbook.nist.gov provides (external link) |
| EPA chemical information | The information is: ofmpub.epa.gov provides (external link) |
| spontaneous combustion temperature | 550°C |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov provided (external link) |
Last Update：2024-04-09 21:11:58
Supplier List
Spot supply
Product Name: O-Chlorophenol Request for quotationCAS: 95-57-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: O-Chlorophenol Request for quotationCAS: 95-57-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: O-Chlorophenol Request for quotation
CAS: 95-57-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 95-57-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: O-Chlorophenol Request for quotation
CAS: 95-57-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 95-57-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: 2-Chlorophenol Request for quotation
CAS: 95-57-8
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
CAS: 95-57-8
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
Spot supply
Product Name: O-Chlorophenol Request for quotationCAS: 95-57-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: O-Chlorophenol Request for quotationCAS: 95-57-8
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3785839865
Product Name: O-Chlorophenol Request for quotation
CAS: 95-57-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
CAS: 95-57-8
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Product Name: O-Chlorophenol Request for quotation
CAS: 95-57-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 95-57-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: 2-Chlorophenol Request for quotation
CAS: 95-57-8
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
CAS: 95-57-8
Tel: 0086-13605431940
Email: xuli678323@126.com
Mobile: +86-13605431940
QQ: 56860987
Wechat: 13605431940
WhatsApp: 13605431940
View History