Name | Pyridazine |
Synonyms | OIZINE o-diazine Pyridazin Pyridazine AKOS 92457 1,2-DIAZINE ORTHODIAZINE 1,2-Diazabenzene 1,2-diazabenzene radical cation |
CAS | 289-80-5 |
EINECS | 206-025-5 |
InChI | InChI=1/C4H4N2/c1-2-4-6-5-3-1/h1-4H |
InChIKey | PBMFSQRYOILNGV-UHFFFAOYSA-N |
Molecular Formula | C4H4N2 |
Molar Mass | 80.09 |
Density | 1.103 g/mL at 25 °C (lit.) |
Melting Point | -8 °C (lit.) |
Boling Point | 208 °C (lit.) |
Flash Point | 185°F |
Water Solubility | MISCIBLE |
Vapor Presure | 0.315mmHg at 25°C |
Appearance | Liquid |
Color | Clear yellow-brown |
Merck | 14,7969 |
BRN | 103906 |
pKa | 2.24(at 20℃) |
Storage Condition | Inert atmosphere,Room Temperature |
Sensitive | Sensitive to heat and air |
Refractive Index | n20/D 1.524(lit.) |
MDL | MFCD00006463 |
Hazard Symbols | Xn - Harmful |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. |
UN IDs | NA 1993 / PGIII |
WGK Germany | 3 |
RTECS | UR5267000 |
FLUKA BRAND F CODES | 8-10 |
TSCA | Yes |
HS Code | 29339980 |
Toxicity | LD50 ipr-mus: 2650 mg/kg PBPHAW 1,542,65 |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Heterocyclic compounds | pyridazine refers to nitrogen-containing six-membered heterocyclic azines, which are isomers of pyrimidine and pyrazines, and are insoluble in petroleum Ether, easily soluble in methanol, ethanol and ether, miscible with water, benzene and dimethylformamide. Pyridazine is a weak base, which can form salts with picric acid, hydrochloric acid, etc.; pyridazine is not prone to aromatic nucleophilic and electrophilic substitution reactions; it is also stable to potassium permanganate; it can be reduced with sodium or alcohol Open the chain and transform into 1, 4-diaminobutane. pyridazine is widely used as a raw material for medicine. For example, long-acting sulfa SMP is a derivative of pyridazine. The antimalarial drug 4-aminosin and the antihypertensive drug hydralazine are all made of pyridazine; It is also used as a raw material for pesticides, preparation of herbicides "Herbicide", "Ethylpyridone", "Bromine", "Da Cao Ether", "Yiyedan", "Da Cao Mie", "Da Cao Zhi", "Insecticide", "Kill Phosphorus" and so on. |